MiR-889 promotes cell growth in human non-small cell lung cancer by regulating KLF9

Han, Xu; Tang, Yihu; Dai, Yawei; Zhou, Tianjun; Zhou, Jingxin; Liu, Xiang; Zhu, Jie; Wu, Yanhu

doi:10.1016/j.gene.2019.02.077

Cited by 16 publications

(15 citation statements)

References 27 publications

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“…Previous studies have shown that miR-889 typically acts as tumor promoter, whereas miR-889-3p functions as a suppressor. For example, Wu et al reported that miR-889 accelerated non-small cell lung cancer cell proliferation and invasion by binding to KLF9 28. Consistently, miR-889 in high levels facilitates tumor development in…”

mentioning

confidence: 94%

Retracted Article: Long non-coding RNA NEAT1 accelerates cell progression in cervical cancer by regulating the miR-889-3p/E2F7 axis through the activation of the PI3K/AKT pathway

2019

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confidence: 94%

Retracted Article: Long non-coding RNA NEAT1 accelerates cell progression in cervical cancer by regulating the miR-889-3p/E2F7 axis through the activation of the PI3K/AKT pathway

2019

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“…Previous studies demonstrated that miR-889 could regulate the tumor cellular behaviors by targeting serval target genes, such as KLF9 [ 31 ], SIX1 [ 32 ], DAB2IP [ 33 ], TAB1 [ 34 ], FGFR2 [ 28 ], TWEAK [ 35 ]. For instance, miR-889 expression was significantly up-regulated in non-small cell lung cancer cell lines and tissues, and miR-889 may play a potential therapeutic role in non-small cell lung cancer by targeting KLF9 to control the proliferation and migration of non-small cell lung cancer [ 31 ]. In colorectal cancer, miR-889 may be involved in controlling the proliferation of CRC by regulating DAB2IP, which provides potential and potential therapeutic targets for colorectal cancer [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma

Wang

Cui

et al. 2021

Diagn Pathol

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Background As a new type of molecular marker, microRNAs (miRNAs) can be used for early diagnosis and prognosis prediction of malignant tumors, and has broad clinical application prospects. This paper mainly studies the important role of miR-889 in the occurrence and development of hepatocellular carcinoma and the prognostic significance of miR-889 in hepatocellular carcinoma. Methods Quantitative real-time PCR analysis detected the expression levels of miR-889 in hepatocellular carcinoma tissues and cell lines. Kaplan-Meier curve and Cox regression analysis were used to explore the prognostic significance of miR-889 in hepatocellular carcinoma. The CCK-8 and Transwell assays assay were used to assess cell proliferation, migration, and invasion abilities ability. Results The expression of miR-889 in hepatocellular carcinoma tissues was significantly higher than that in adjacent tissues. Overexpression of miR-889 was significantly associated with TNM stage, hepatitis B virus infection, and cirrhosis. Patients with high miR-889 expression had shorter overall survival than those with low miR-889 expression. And functional studies in two hepatocellular carcinoma cell lines have shown that overexpression of miR-889 significantly promoted cell proliferation, migration, and invasion in vitro. Conclusions Overall, miR-889 was upregulated in hepatocellular carcinoma tissues and cell lines, and overexpression of miR-889 promoted cell proliferation, migration, and invasion in hepatocellular carcinoma cells. Based on our findings, high expression of miR-889 may promote the progression of hepatocellular carcinoma, and high expression of miR-889 is also forecasted for an unfavorable prognosis in hepatocellular carcinoma.

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“…MiR-889, as a novel miRNA, was not reported in osteogenic differentiation of hBMMSCs. Several studies reported that the role and function of miR-889 in colorectal cancer [18], osteosarcoma [14], and lung cancer [13]. In this research, we firstly used a clinical sample to identify the relative expression of miR-889 and WNT7A.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, Han et al [13] revealed that miR-889 inhibits non-small cell lung cancer progression by targeting Krueppel-like factor 9 (KLF9). Ge et al found that hsa-miR-889 promotes the proliferation of osteosarcoma through inhibiting myeloid cell nuclear differentiation antigen expression [14].…”

Section: Introductionmentioning

confidence: 99%

The mechanism of miR-889 regulates osteogenesis in human bone marrow mesenchymal stem cells

Ding

Shi

2019

J Orthop Surg Res

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Background: Bone marrow mesenchymal stem cells (BMMSCs) can be used for bone regeneration in the specified condition. Osteogenic differentiation of BMMSCs is controlled by microRNAs (miRNAs) and other factors. This study was aimed to identify the role and mechanism of miR-889 in regulating the osteogenic differentiation of BMMSCs. Methods: Osteoporosis patients and normal control bone tissues were collected and used PCR techniques to identify the change of miR-889 and WNT7A. Moreover, the dynamic change of miR-889 and WNT7A during osteogenic differentiation of BMMSCs was also measured. Bioinformatic analysis was performed to identify the target genes and potential pathways of miR-889. Then, we constructed miR-889 mimic and inhibitor, ALP staining, ARS, osteoblastic-related protein, and Wnt β-catenin signaling pathway-related protein were also measured. WNT7A siRNA was also used to verify the function of miR-889. Results: In the present study, we showed that miR-889 expression was upregulated in osteoporosis patients than healthy control. However, the miR-889 expression was downregulated during osteogenic differentiation. Bioinformatics analysis found that miR-889 targets 666 genes and mainly through Wnt β-catenin signaling pathway. Administrated miR-889 mimic, the ALP activity, and calcium deposition were decreased than the control group, while miR-889 inhibitor shown the opposite trend. And miR-889 could bind the 3′UTR of WNT7A. We further used WNT7A siRNA to explore the function of miR-889, and the results revealed that co-cultured with miR-889 inhibitor and WNT7A siRNA was associated with a reduction of ALP activity and calcium deposition and osteoblastic-related proteins than miR-889 inhibitor alone. Conclusion: Our results revealed that miR-889 plays a negative role in inducing osteogenic differentiation of BMSCs through Wnt β-catenin signaling pathway.

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MiR-889 promotes cell growth in human non-small cell lung cancer by regulating KLF9

Cited by 16 publications

References 27 publications

Retracted Article: Long non-coding RNA NEAT1 accelerates cell progression in cervical cancer by regulating the miR-889-3p/E2F7 axis through the activation of the PI3K/AKT pathway

Retracted Article: Long non-coding RNA NEAT1 accelerates cell progression in cervical cancer by regulating the miR-889-3p/E2F7 axis through the activation of the PI3K/AKT pathway

Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma

The mechanism of miR-889 regulates osteogenesis in human bone marrow mesenchymal stem cells

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