MiR146a and MiR499 Gene Polymorphisms in Iranian Periodontitis and Peri-implantitis Patients

Kadkhodazadeh, Mahdi; Jafari, Alireza; Amid, Reza; Ebadian, Ahmad Reza; Alipour, Marjan Mohammad; Mollaverdi, Fatemeh; Lafzi, Ardeshir

doi:10.1615/jlongtermeffmedimplants.2013007073

Cited by 20 publications

(24 citation statements)

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“…However, although peri-implant infections are well described histopathologically, the molecular events that govern the development of these infections have not yet been completely characterized. Certain studies have attempted to correlate miRNAs with the pathogenesis of peri-implantitis [ 26 ]. In particular, it has been noted that miR-146a and miR-499 gene polymorphisms may be genetic determinants of an increased risk of peri-implantitis in Iranians.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs

Chen

et al. 2017

Bioscience Reports

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Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed to investigate the differential expression of miRNAs in canine peri-implantitis and to explore the functions of their target genes. An miRNA sequence analysis was used to identify differentially expressed miRNAs in peri-implantitis. Under the criteria of a fold-change >1.5 and P<0.01, 8 up-regulated and 30 down-regulated miRNAs were selected for predictions of target genes and their biological functions. Based on the results of Gene Ontology (GO) and KEGG pathway analyses, these miRNAs may fine-tune the inflammatory process in peri-implantitis through an intricate mechanism. The results of quantitative real-time PCR (qRT-PCR) revealed that let-7g, miR-27a, and miR-145 may play important roles in peri-implantitis and are worth further investigation. The results of the present study provide insights into the potential biological effects of the differentially expressed miRNAs, and specific enrichment of target genes involved in the mitogen-activated protein kinase (MAPK) signaling pathway was observed. These findings highlight the intricate and specific roles of miRNAs in inflammation and osteoclastogenesis, both of which are key aspects of peri-implantitis, and thus may contribute to future investigations of the etiology, underlying mechanism, and treatment of peri-implantitis.

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Section: Discussionmentioning

confidence: 99%

MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs

Chen

et al. 2017

Bioscience Reports

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“…Some studies have found an association of miRNA146a gene polymorphism with periodontitis in southIndian and Iranian population. 18,19 This microRNA146a is in turn regulated by the apolipoprotein E. ApoE regulates inflammation by suppressing the NF-kβ signaling. ApoE increases the expression of the transcription factor PU.1 and which in turn increases miRNA146a levels to suppress the NF-kβ signaling.…”

Section: Hypothesesmentioning

confidence: 99%

The link between the genetic polymorphisms of the innate immune signaling molecular factors with periodontitis

Kaarthikeyan

Balakrishnan²,

Jayakumar

2018

J Biol Res

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Periodontitis is a chronic inflammatory disease causing destruction of supporting tissues of teeth. Even though the gramnegative anaerobes are essential for the initiation of periodontal destruction, multiple risk factors are essential for the progression of the disease. The genetic risk factor plays a significant role in the etiopathogenesis of periodontal disease. The innate immune mechanism is the first line of defense in screening and combating the invading periodontal pathogens. The genetic polymorphisms in the 3'UTR region of the innate immune signaling molecular factors like toll-like receptors, nod-like receptors and the polymorphisms in the epigenetic regulators of these factors like microRNA146a, apolipoproteinE might play an important role in the etiopathogenesis of periodontal destruction.

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“…A study conducted comparing gingival (gum) biopsy samples derived from chronic periodontitis subjects, peri-implantitis (dental implants) subjects, and healthy subjects showed significant differential expression of miR-146a and miR-499 among these groups. 83 Various studies comparing healthy versus diseased gingiva have demonstrated specific miRNA deregulations in periodontal tissue homeostasis and pathology targeting TLR and TNF-α pathways. 10,11,84 Furthermore, our pilot investigation sought to determine whether miRNA expression differed in gingival biopsies obtained from obese/non-obese subjects with or without periodontal disease.…”

Section: Periodontal and Endodontic Diseasesmentioning

confidence: 99%

microRNAs: Emerging players in oral cancers and inflammatory disorders

et al. 2017

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Association of oral diseases and disorders with altered microRNA profiles is firmly recognized. These evidences support the potential use of microRNAs as therapeutic tools for diagnosis, prognosis, and treatment of various diseases. In this review, we highlight the association of altered microRNA signatures in oral cancers and oral inflammatory diseases. Advances in our ability to detect microRNAs in human sera and saliva further highlight their clinical value as potential biomarkers. We have discussed key mechanisms underlying microRNA dysregulation in pathological conditions. The use of microRNAs in diagnostics and their potential therapeutic value in the treatment of oral diseases are reviewed.

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MiR146a and MiR499 Gene Polymorphisms in Iranian Periodontitis and Peri-implantitis Patients

Abstract: MiR146a (rs2910146) and MiR499 (rs3746444) gene polymorphisms may be genetic determinants for increased risk of chronic periodontitis and peri-implantitis in Iranians. More studies with larger sample sizes in different populations are necessary for determining the effect of these SNPs.

Cited by 20 publications

References 0 publications

MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs

MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs

The link between the genetic polymorphisms of the innate immune signaling molecular factors with periodontitis

microRNAs: Emerging players in oral cancers and inflammatory disorders

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