Mirimostim (macrophage colony‐stimulating factor; M‐CSF) improves chemotherapy‐induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function

Hidaka, Takao; Akada, Shinobu; Teranishi, Akiko; Morikawa, Hajime; Sato, Shinji; Yoshida, Yūji; Yajima, Akira; Yaegashi, Nobuo; Okamura, Koji; Saito, Shigeru

doi:10.1111/j.1349-7006.2003.tb01524.x

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…Studies by Hidaka et al showed that administration of CSF-1 to patients with ovarian cancer resulted in the improvement of NK and T cell functions [30]. Similarly, infusion of recombinant CSF-1 in patients with melanoma led to an increase in the number of circulating monocytes, suggesting that blocking CSF-1 action could be therapeutically useful [31].…”

Section: The Role Of Cytokines In Mdsc Developmentmentioning

confidence: 99%

Signaling pathways involved in MDSC regulation

Trikha

Carson

2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

156

140

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The immune system has evolved mechanisms to protect the host from the deleterious effects of inflammation. The generation of immune suppressive cells like myeloid derived suppressor cells (MDSCs) that can counteract T cell responses represents one such strategy. There is an accumulation of immature myeloid cells or MDSCs in bone marrow (BM) and lymphoid organs under pathological conditions such as cancer. MDSCs represent a population of heterogeneous myeloid cells comprising of macrophages, granulocytes and dendritic cells that are at early stages of development. Although, the precise signaling pathways and molecular mechanisms that lead to MDSC generation and expansion in cancer remains to be elucidated. It is widely believed that perturbation of signaling pathways involved during normal hematopoietic and myeloid development under pathological conditions such as tumorogenesis contributes to the development of suppressive myeloid cells. In this review we discuss the role played by key signaling pathways such as PI3K, Ras, Jak/Stat and TGFb during myeloid development and how their deregulation under pathological conditions can lead to the generation of suppressive myeloid cells or MDSCs. Targeting these pathways should help in elucidating mechanisms that lead to the expansion of MDSCs in cancer and point to methods for eliminating these cells from the tumor microenvironment.

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Section: The Role Of Cytokines In Mdsc Developmentmentioning

confidence: 99%

Signaling pathways involved in MDSC regulation

Trikha

Carson

2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

156

140

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“…These in vitro data were in agreement with animal studies of invasive candidiasis, aspergillosis and trichosporonosis, where M‐CSF treatment was associated with improved survival and reduced fungal burden (Cenci et al , 1991; Sasaki et al , 2000; Gonzalez et al , 2001). Administration of M‐CSF in ovarian cancer patients prevented the chemotherapy‐induced decrease of Th1/Th2 cell ratio (Hidaka et al , 2003).…”

Section: Cytokines and Antifungal Host Defence – Preclinical Datamentioning

confidence: 99%

Cytokines and fungal infections

Antachopoulos¹,

Roilides²

2005

Br J Haematol

110

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Summary The very poor outcome of invasive fungal infections (IFI) in patients with haematological malignancies or recipients of haematopoietic stem cell transplantation is largely attributed to their compromised host defence mechanisms. The restoration or augmentation of immune responses in these patients is now considered as one of the cornerstones of effective antifungal therapy. Major advances in the field of experimental immunology have provided insight on the important regulatory role of cytokines in both innate and adaptive immunity to fungal pathogens. Preclinical studies have convincingly demonstrated that immunomodulation with cytokines can enhance the antifungal activity of neutrophils and monocytes/macrophages as well as upregulate protective T‐helper type 1 adaptive immune responses. Evidence on the clinical use of cytokines in immunocompromised hosts with IFI is, however, still scant and inconclusive. The present review summarizes experimental and clinical data on the role of cytokines in the immune response to fungal pathogens and on their potential use for prevention or treatment of fungal infections. Implications for future research are also briefly discussed.

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“…Like cytokine production and cytolytic activity, NK cell functions are seriously compromised [8] in various immunosuppressive diseases such as cancer, mainly because of disturbed Th1/Th2 homeostasis [9]. Such situations demand the participation of exogenous IL-12-inducing factors to enable optimal NK cell function and also to produce effective, host-protective Th1 phenotype [10].…”

Section: Introductionmentioning

confidence: 99%