2023
DOI: 10.1002/ehf2.14493
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miRNA‐103‐3p‐Hlf regulates apoptosis and autophagy by targeting hepatic leukaemia factor in heart failure

Abstract: AimsCardiomyocyte apoptosis is an important factor leading to the occurrence and development of heart failure (HF), which is associated with high mortality of patients with cardiovascular diseases. This study aims to investigate the underlying mechanisms of HF in terms of expression and regulation patterns using bioinformatics and experimental validation.Methods and resultsTwo HF datasets were collected: a dataset GSE112056 downloaded from the GEO database (including mRNA and miRNA sequencing data) and another… Show more

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Cited by 6 publications
(1 citation statement)
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“…Interestingly, there is a dedicated consortium to annotate cardiovascular genes (over 4000) and they are also focusing on the GO annotation of miRNAs (http://www.ebi.ac.uk/QuickGO/GProteinSet?id=BHF-UCL (accessed on 18 December 2023); http://www.ucl.ac.uk/functional-gene-annotation/ cardiovascular (accessed on 18 December 2023)). Finally, regulatory relationships can also be searched between transcription factors, miRNAs, and mRNAs from genes identified in those PPI networks (e.g., [187]). For this, a web-based gene set analysis toolkit, such as WebGestalt [168], or the database Transcriptional Regulatory Relationships Unraveled by Sentence-based Text-mining (TTRUST, [169]) can be used.…”
Section: Bioinformatic Tools For Functional Analysismentioning
confidence: 99%
“…Interestingly, there is a dedicated consortium to annotate cardiovascular genes (over 4000) and they are also focusing on the GO annotation of miRNAs (http://www.ebi.ac.uk/QuickGO/GProteinSet?id=BHF-UCL (accessed on 18 December 2023); http://www.ucl.ac.uk/functional-gene-annotation/ cardiovascular (accessed on 18 December 2023)). Finally, regulatory relationships can also be searched between transcription factors, miRNAs, and mRNAs from genes identified in those PPI networks (e.g., [187]). For this, a web-based gene set analysis toolkit, such as WebGestalt [168], or the database Transcriptional Regulatory Relationships Unraveled by Sentence-based Text-mining (TTRUST, [169]) can be used.…”
Section: Bioinformatic Tools For Functional Analysismentioning
confidence: 99%