MiRNA-138–5p: A strong tumor suppressor targeting PD-L-1 inhibits proliferation and motility of breast cancer cells and induces apoptosis

Rasoolnezhad, Mina; Safaralizadeh, Reza; Feizi, Mohammad Ali Hosseinpour; Khojasteh, S M Banan; Baradaran, Behzad

doi:10.1016/j.ejphar.2021.173933

Cited by 27 publications

(17 citation statements)

References 56 publications

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“…Further investigation of the molecular mechanism demonstrated that upregulation of miR-149-3p reversed T cell exhaustion by targeting several immune checkpoints, including PD-1, TIM-3, BTLA, and Foxp1 ( 74 ). In addition, two downregulated miRNAs, miR-424-5p ( 75 ) and miR-138-5p ( 76 ), were shown to reduce breast cancer cell viability and restrain T cell exhaustion by upregulating the expression of the effector cytokines IL-2, TNF-α, and IFN-γ, and downregulating the expression of the regulatory cytokine IL-10 by targeting PD-L1.…”

Section: Breast Cancermentioning

confidence: 99%

Non-coding RNAs: Key players in T cell exhaustion

Wang²

2022

Front. Immunol.

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T cell exhaustion caused by continuous antigen stimulation in chronic viral infections and the tumor microenvironment is a major barrier to successful elimination of viruses and tumor cells. Although immune checkpoint inhibitors should reverse T cell exhaustion, shortcomings, such as off-target effects and single targets, limit their application. Therefore, it is important to identify molecular targets in effector T cells that simultaneously regulate the expression of multiple immune checkpoints. Over the past few years, non-coding RNAs, including microRNAs and long non-coding RNAs, have been shown to participate in the immune response against viral infections and tumors. In this review, we focus on the roles and underlying mechanisms of microRNAs and long non-coding RNAs in the regulation of T cell exhaustion during chronic viral infections and tumorigenesis. We hope that this review will stimulate research to provide more precise and effective immunotherapies against viral infections and tumors.

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Section: Breast Cancermentioning

confidence: 99%

Non-coding RNAs: Key players in T cell exhaustion

Wang²

2022

Front. Immunol.

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“…Studies have shown that miRNA-21 (a mammalian microRNA encoded by the MIR21 gene) can control the proliferation and apoptosis of many cell types, including cancer cells [ 114 ]. As demonstrated by Rasoolnezhad et al (2021), miR-128-5p inhibits proliferation in breast cancer cells by regulating the PI3K/AKT pathway [ 115 ]. Moreover, miRNA-138-5p induced apoptosis by increasing the levels of caspase-9 and caspase-3 and stopping the cell cycle in the sub-G1 phase.…”

Section: Importance Of Milk Micrornamentioning

confidence: 99%

Importance of Bioactive Substances in Sheep’s Milk in Human Health

Flis

Molik

2021

IJMS

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Sheep’s milk is an important source of bioactive substances that have health-promoting functions for the body. The valuable composition of sheep’s milk is due to the high content of fatty acids, immunoglobulins, proteins, hormones, vitamins and minerals. Many biopeptides found in milk have antibacterial, antiviral and anti-inflammatory properties. The bioactive substances of sheep’s milk also show anticancer properties. Sheep’s milk, thanks to its content of CLA and orotic acid, prevents the occurrence of type 2 diabetes, Alzheimer’s disease and cancer. Sheep’s milk, as a product rich in bioactive substances, can be used as a medical aid to support the body in the fight against neurological and cancer diseases.

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“…The role of miRNAs is mainly achieved through combination with the base of the 3′-untranslated region (3′-UTR) of the target gene mRNAs to suppress their expressions by degradation and translational inhibition (Chen et al 2015 ). A single miRNA can regulate hundreds of target gene mRNAs, and a single target gene mRNA can be regulated by several different miRNAs (Jackson and Standart 2007 ), such as microRNA-138-5p (miR-138-5p); it suppresses MnCl 2 ‐induced autophagy by targeting SIRT1 in SH‐SY5Y cells (Ma et al 2019a ), reverses gefitinib resistance in non-small-cell lung cancer cells via targeting G protein–coupled receptor (Gao et al 2014 ), and inhibits proliferation and motility of breast cancer by targeting PD-L-1 (Rasoolnezhad et al 2021 ). In recent years, miRNA-138-5p was found highly expressed in nervous system and play an important role in regulating memory and axon regeneration (Bao and Cao 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Catalpol Mitigates Alzheimer's Disease Progression by Promoting the Expression of Neural Stem Cell Exosomes Released miR-138-5p

et al. 2023

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Alzheimer’s disease (Alzheimer’s disease, AD) is a neurodegenerative disease characterized by senile plaque deposition and neurofibrillary tangles. The pathogenesis of AD is complicated and the drugs used to treat AD are single-targeted drugs, which can only improve or alleviate the symptoms of patients, but cannot delay or prevent the progress of the disease. Because of its ability to act on multiple targets, multiple systems, multiple links, and multiple pathways, Chinese herbal compound prescriptions have shown unique advantages in the research and treatment of AD. Our previous study has demonstrated the protect role of the Chinese medicine Rehmannia in AD. However, the underlying mechanism remains unclear. In the present study, both in vitro and vivo experiments were employed, and we found Catalpol (Ca), the main extract of Rehmannia, could mitigate AD progression both in vitro and in vivo by promoting miR-138-5p level in neural stem cell secreted exosomes

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MiRNA-138–5p: A strong tumor suppressor targeting PD-L-1 inhibits proliferation and motility of breast cancer cells and induces apoptosis

Cited by 27 publications

References 56 publications

Non-coding RNAs: Key players in T cell exhaustion

Non-coding RNAs: Key players in T cell exhaustion

Importance of Bioactive Substances in Sheep’s Milk in Human Health

Catalpol Mitigates Alzheimer's Disease Progression by Promoting the Expression of Neural Stem Cell Exosomes Released miR-138-5p

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