miRNA-150-5p associate with antihypertensive effect of epigallocatechin-3-gallate revealed by aorta miRNome analysis of spontaneously hypertensive rat

Bian, Qian; Tian, Chongchong; Ling, Xiao-Hong; Yu, Lili; Ding, Feng-yun; Huo, Jianghua; Zhu, Liucun; Wen, Yaolin; Zhang, Jianhua; Jing, Pu

doi:10.1016/j.lfs.2018.04.041

Cited by 24 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As scientific advances are developed in miRNA and tea research, an increasing number of molecular effects are recognized due to miRNA regulation. miRNAs induced by green tea have wide-ranging beneficial effects: tumor suppression by negatively regulating gene expression of oncogenic factors, reduction in hypertension and neurodegeneration, and improvement in arthritis (10,16,19,34,133,137). Generally, green tea is safe to consume even at high concentrations.…”

Section: Egcg Controls Mirnas Expression In Cancer and Immune T Cellsmentioning

confidence: 99%

Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

2021

View full text Add to dashboard Cite

Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mechanisms involved in the modification of T cell function by green tea polyphenol EGCG. The case is made that EGCG downregulates calcium channel activity by influencing miRNAs regulating expression of the channel at the post-transcriptional level.

show abstract

Section: Egcg Controls Mirnas Expression In Cancer and Immune T Cellsmentioning

confidence: 99%

Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

2021

View full text Add to dashboard Cite

show abstract

“…In another study, EGCG has shown to affect Polycomb-group (PcG) proteins which can compact chromatin and silence cancer-related genes through regulating histone methylation and acetylation [277]. Additionally, EGCG has also been found to modulate miRNA expression in human nasopharyngeal carcinoma CNE2 cells [278], osteoarthritis chondrocytes [279], osteosarcoma cells [280], and spontaneously hypertensive rat [281] (Table 4).…”

Section: Epigenetics Diets and Their Roles On Epigenetic Regulationmentioning

confidence: 99%

Prenatal epigenetics diets play protective roles against environmental pollution

Chen

Tollefsbol

2019

Clin Epigenet

View full text Add to dashboard Cite

It is thought that germ cells and preimplantation embryos during development are most susceptible to endogenous and exogenous environmental factors because the epigenome in those cells is undergoing dramatic elimination and reconstruction. Exposure to environmental factors such as nutrition, climate, stress, pathogens, toxins, and even social behavior during gametogenesis and early embryogenesis has been shown to influence disease susceptibility in the offspring. Early-life epigenetic modifications, which determine the expression of genetic information stored in the genome, are viewed as one of the general mechanisms linking prenatal exposure and phenotypic changes later in life. From atmospheric pollution, endocrine-disrupting chemicals to heavy metals, research increasingly suggests that environmental pollutions have already produced significant consequences on human health. Moreover, mounting evidence now links such pollution to relevant modification in the epigenome. The epigenetics diet, referring to a class of bioactive dietary compounds such as isothiocyanates in broccoli, genistein in soybean, resveratrol in grape, epigallocatechin-3-gallate in green tea, and ascorbic acid in fruits, has been shown to modify the epigenome leading to beneficial health outcomes. This review will primarily focus on the causes and consequences of prenatal environment pollution exposure on the epigenome, and the potential protective role of the epigenetics diet, which could play a central role in neutralizing epigenomic aberrations against environmental pollutions.

show abstract

“…Epigallocatechin-3-gallate (EGCG) is a powerful natural antioxidant with both hypolipidemic activity and antihypertensive effects. Several studies support the view that EGCG has many benefits in the treatment of cardiovascular diseases [82][83][84]. However, the low bioavailability and instability of EGCG limit its effectiveness in the prevention and treatment of human cardiovascular diseases.…”

Section: Parkinson's Diseasementioning

confidence: 96%

Nanomedicine Based on Natural Products: Improving Clinical Application Potential

Zhao

et al. 2022

Journal of Nanomaterials

View full text Add to dashboard Cite

Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability and short biological half-life limit their clinical application. In recent years, more and more attention has been paid to the science of drug delivery by nanoscale materials. A large number of in vitro and in vivo studies have further confirmed the efficacy and safety of nanomedicine based on natural products in preclinical models of various diseases. In this review, we summarized the achievements of nanomaterials in improving the efficacy of natural products, introduced the research progress in several key fields of natural product-based nanomedicine in medical application, and discussed the challenges and prospects of clinical transformation of nanomedicine.

show abstract

miRNA-150-5p associate with antihypertensive effect of epigallocatechin-3-gallate revealed by aorta miRNome analysis of spontaneously hypertensive rat

Cited by 24 publications

References 52 publications

Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

Prenatal epigenetics diets play protective roles against environmental pollution

Nanomedicine Based on Natural Products: Improving Clinical Application Potential

Contact Info

Product

Resources

About