Nanomedicine Based on Natural Products: Improving Clinical Application Potential

Li, Zhe; Zhao, Tingting; Li, Jiaxin; Yu, Qingying; Feng, Yu; Xie, Yicheng; Peng, Sun

doi:10.1155/2022/3066613

Cited by 14 publications

(7 citation statements)

References 91 publications

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“…Furthermore, gold nanoparticle-based drug-delivery systems are also capable of reaching the central nervous system [ 87 ]. It is worth noting that drug-delivery nanoparticles can either stimulate or inhibit the immune response, and they can reside in the body, so researchers must design appropriate nanodrugs, modify them according to disease characteristics, and conduct extensive immunotoxicology research before moving forward with clinical trials [ 95 ]. Natural product extracts may have a high concentration of constituents, and the combination of various active ingredients in extracts can provide synergistic effects, resulting in improved antioxidant and disease-modifying action [ 96 , 97 ].…”

Section: Review Methodologymentioning

confidence: 99%

Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review

Wijeweera

Wijekoon

Gonawala

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Neuroimmune diseases are a group of disorders that occur due to the dysregulation of both the nervous and immune systems, and these illnesses impact tens of millions of people worldwide. However, patients who suffer from these debilitating conditions have very few FDA-approved treatment options. Neuroimmune crosstalk is important for controlling the immune system both centrally and peripherally to maintain tissue homeostasis. This review aims to provide readers with information on how natural products modulate neuroimmune crosstalk and the therapeutic implications of natural products, including curcumin, epigallocatechin-3-gallate (EGCG), ginkgo special extract, ashwagandha, Centella asiatica, Bacopa monnieri, ginseng, and cannabis to mitigate the progression of neuroimmune diseases, such as Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, depression, and anxiety disorders. The majority of the natural products based clinical studies mentioned in this study have yielded positive results. To achieve the expected results from natural products based clinical studies, researchers should focus on enhancing bioavailability and determining the synergistic mechanisms of herbal compounds and extracts, which will lead to the discovery of more effective phytomedicines while averting the probable negative effects of natural product extracts. Therefore, future studies developing nutraceuticals to mitigate neuroimmune diseases that incorporate phytochemicals to produce synergistic effects must analyse efficacy, bioavailability, gut-brain axis function safety, chemical modifications, and encapsulation with nanoparticles.

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Section: Review Methodologymentioning

confidence: 99%

Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review

Wijeweera

Wijekoon

Gonawala

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…For effective absorption, API needs to be present in an aqueous solution at the site of absorption. Thus, for increasing GI absorption, it is of utmost importance that the aqueous solubility of the nutraceutical API must be improved [53].…”

Section: Impact Of Co-crystallization On Gastro-intestinal Absorption...mentioning

confidence: 99%

Co-Crystallization Techniques for Improving Nutraceutical Absorption and Bioavailability

Gajbhiye¹,

Das²,

Patil³

2023

Drug Formulation Design

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Nutraceuticals is an umbrella term for therapeutic leads derived from plants, animals and/or microbial species. Being synthesized in nature’s own laboratory a nutraceuticals have structural and functional features for interacting with an array of physiological targets. However, because of this very structural complexity and diversified nature, nutraceuticals often suffer from diminished gastrointestinal (GI) absorption and limited systemic bioavailability. Thus, in-spite of having an obvious edge over synthetic molecules, pharmaceutical applicability of nutraceuticals play second fiddle in the present pharmaceutical prospective. In this regard, co-crystallization of nutraceuticals have evolved as an attractive prospect. Co-crystallization causes stoichiometric non-covalent binding between nutraceutical API (active pharmaceutical ingredient) and a pharmaceutically acceptable co-former creating a single-phase crystalline material. Nutraceutical co-crystals thus created possess excellent absorption and bioavailability attributes. The principal aim of the current chapter is to highlight co-crystallization as the means of nutraceutical ascendancy over toxic synthetic drugs currently dominating the pharmaceutical market. In the current chapter the authors provide a detail exposition on the methods and application of co-crystallization in context of nutraceutical absorption and bioavailability. Herein, we discuss in detail about the constituents, characteristics, mechanism of action and protocol for preparation of nutraceutical co-crystals with relevant references from current and past studies.

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“…The most commonly used strategies include drug placement inside organic or inorganic materials, physically enveloping these molecules, forming NPs widely used in drug delivery. Types of nanocarrier mainly include organic and polymeric NPs, nanoemulsions, solid lipidic NPs, and inorganic or metallic NPs [ 90 , 91 ]. Each of these systems has unique properties and therefore can be selectively designed for specific medical applications.…”

Section: Nanotechnologymentioning

confidence: 99%

Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections

et al. 2023

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Respiratory viral diseases are among the most important causes of disability, morbidity, and death worldwide. Due to the limited efficacy or side effects of many current therapies and the increase in antiviral-resistant viral strains, the need to find new compounds to counteract these infections is growing. Since the development of new drugs is a time-consuming and expensive process, numerous studies have focused on the reuse of commercially available compounds, such as natural molecules with therapeutic properties. This phenomenon is generally called drug repurposing or repositioning and represents a valid emerging strategy in the drug discovery field. Unfortunately, the use of natural compounds in therapy has some limitations, due to their poor kinetic performance and consequently reduced therapeutic effect. The advent of nanotechnology in biomedicine has allowed this limitation to be overcome, showing that natural compounds in nanoform may represent a promising strategy against respiratory viral infections. In this narrative review, the beneficial effects of some promising natural molecules, curcumin, resveratrol, quercetin, and vitamin C, which have been already studied both in native form and in nanoform, against respiratory viral infections are presented and discussed. The review focuses on the ability of these natural compounds, analyzed in in vitro and in vivo studies, to counteract inflammation and cellular damage induced by viral infection and provide scientific evidence of the benefits of nanoformulations in increasing the therapeutic potential of these molecules.

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Nanomedicine Based on Natural Products: Improving Clinical Application Potential

Cited by 14 publications

References 91 publications

Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review

Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review

Co-Crystallization Techniques for Improving Nutraceutical Absorption and Bioavailability

Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections

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