miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer

Zhang, Wenjun; Sun, Zheng; Su, Liang; Wang, Rui; Jiang, Yiming; Yu, Deng‐Feng; Zhang, Fujie; Sun, Zhe; Liang, Wenbo

doi:10.1016/j.ejphar.2018.02.019

Cited by 49 publications

(31 citation statements)

References 29 publications

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“…Blockade of Wnt1 by WIF-1 or its antibody induced a significant apoptosis of human CRC cells containing mutations of APC, CTNNB1, and AXIN2 (79). Moreover, the ectopic expression of microRNA (miR)-200b-3p and miR-185 could significantly inhibit the proliferation and induce the apoptosis of CRC cells by targeting the canonical Wnt1/β-catenin signaling (80,81). However, researches on the Wnt1 expression in human CRC tissues have yielded some conflicting results that the decrease or the increase of Wnt1 expression was detected in CRC tissues compared with normal colorectal mucosa (25,27), and a study even found that the expression level of Wnt1 was decreased in human CRC tissues and CRC mice, whereas Wnt1 knockdown could still dramatically decrease the cell migration and the invasion of human CRC cells, and β-catenin expression was also enhanced in the tumors, indicating that Wnt1 expression could be regulated by more complicated mechanisms during CRC tumorigenesis (82).…”

Section: Wnt16mentioning

confidence: 99%

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

et al. 2020

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Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt ligands (Wnts) are secreted glycoproteins and fundamentally essential for the transduction of Wnt signaling pathway. However, the 19 members of Wnts in humans imply a daunting complexity of Wnt signaling and biological effects, and our understanding of their roles in CRC tumorigenesis is still quite rudimentary. This review will give an overview of the structural characteristics and maturation process of Wnts. The expression pattern of all human Wnts in CRC tissues, including Wnt1, Wnt2,

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Section: Wnt16mentioning

confidence: 99%

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

et al. 2020

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“…Increasing the expression of miR-422a could inhibit CRC cell growth and promote cell apoptosis in colorectal cancer cells. It was also reported that miR-422a restricts colorectal cancer by inhibiting the p38/MAPK pathway[ 161 ]. Therefore, miRNAs are emerging as potential targets in CRC.…”

Section: Mirnas and Colorectal Cancermentioning

confidence: 99%

Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review

Pandurangan

Divya

Kumar

et al. 2018

WJGO

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Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APCmin/+ mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine. During CRC progression, several signal transduction pathways are activated. Among the major signal transduction pathways are p53, Transforming growth factor beta, Wnt/β-catenin, Delta Notch, Hippo signalling, nuclear factor erythroid 2-related factor 2 and Kelch-like ECH-associated protein 1 pathways. These signalling pathways collaborate with cell death mechanisms, which include apoptosis, necroptosis and autophagy, to determine cell fate. Extensive research has been carried out in our laboratory to investigate these signal transduction and cell death mechanistic pathways in CRC. This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways.

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“…Taken together, our results highlight the potential clinical signi cance of WNT4, suggesting that further studies are needed to investigate the diagnostic applications of WNT4 in CRC Although the upregulation of WNT expression had been extensively investigated in CRC and corresponding liver metastasis [29][30][31], the role of WNT4 in CRC has not been explored. In our study, we identi ed WNT4 could promote metastasis of CRC through WNT4/β-catenin cascade via EMT.…”

Section: Discussionmentioning

confidence: 88%

WNT4, a potential biomarker in serum for colorectal cancer, promotes metastasis through WNT4/β-catenin pathway

Yang

Shang

et al. 2020

Preprint

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Background Wingless and Int-related protein (Wnt) ligands were aberrantly expressed in human diseases. However, the aberrant level of Wnt ligands have not been explored in serum. Here, we aimed to identify the WNT4 level in serum and explore its oncogenic role in colorectal cancer (CRC). Methods Serum samples from 40 CRC patients and 28 healthy donors were collected to measure the levels of WNT4. CRC tissue samples from patients were collected to explore the resource of WNT4. Further, we used CRC cells and xenograft mouse model to explore the oncogenic role of WNT4. Results WNT4 was significantly upregulated in serum of colorectal cancer (CRC) patients, and CRC tissues were identified as an important source of elevated WNT4 levels in CRC patients. Interestingly, the elevated WNT4 in serum was downregulated after tumor resection. Next, we found that WNT4 could contributed to epithelial-to-mesenchymal transition and activated fibroblasts by activating WNT4/β-catenin pathway in vitro and in vivo; besides, angiogenesis was also induced via WNT4/β-catenin/Ang2 pathway. Those effects could be reversed by ICG-001, a β-catenin/TCF inhibitor. Conclusion These data indicated that WNT4 may be a potential biomarker for CRC and provided evidence to support a critical role of WNT4 in promoting CRC cell metastasis by inducing epithelial-to-mesenchymal transition, activating fibroblasts and promoting angiogenesis in the colorectal tumor microenvironment.

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miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer

Cited by 49 publications

References 29 publications

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review

WNT4, a potential biomarker in serum for colorectal cancer, promotes metastasis through WNT4/β-catenin pathway

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