miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells

Wan, Lin; Miao, Yu; Meng, Xiangkun; Huang, Ying; Zhao, Wanli; Ruan, Jigang

doi:10.1002/2211-5463.12838

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…While Zhu et al validated that LINC00994 repressed the malignant behaviors of pancreatic cancer cells through regulating the miR-765-3p/RUNX2 axis (which means that miR-765 accelerated the development of HCC) [ 41 ]. The oncogenic effect of miR-765 is not only limited to these two tumors, but also plays a similar role in esophageal squamous cell carcinoma [ 42 ], gastric cancer [ 43 ], and osteosarcoma [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation

et al. 2022

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Background Hepatocellular carcinoma (HCC) is one of the most malignant tumors to threaten human life, and the survival rate remains low due to delayed diagnosis. Meanwhile, lncRNAs have great potential for application in tumor prognosis, therefore relevant research in hepatocellular carcinoma is indispensable. Methods Based on the EZH2 expression, the differentially expressed lncRNAs DElncRNAs), miRNAs (DEmiRNAs), and mRNAs (DEmRNAs) were identified in hepatocellular carcinoma by using the TCGA database. Bioinformatics technology was utilized to determine the effect of key genes in HCC progression. The methylation and immune infiltration analyses were performed to explore the underlying function of hub genes. Finally, cellular function experiments were performed to investigate the association between identified genes and biological phenotypes in HCC. Results lncRNA-AC079061.1, hsa-miR-765, and VIPR1 were identified as independent factors that affect the prognosis of hepatocellular carcinoma. The immune infiltration analyses revealed that lncRNA-AC079061.1 can alter the immune microenvironment and thus inhibit the development of HCC by regulating the expression of an immune-related gene (VIPR1). Methylation analyses demonstrated that VIPR1 expression is negatively related to the methylation level in HCC. Experimental results suggested that lncRNA-AC079061.1 and VIPR1 were frequently downregulated in HCC cells, while hsa-miR-765 was significantly upregulated. Moreover, the lncRNA-AC079061.1/VIPR1 axis suppressed the proliferation and invasion of HCC cells. Conclusion The present study identified the lncRNA-AC079061.1/VIPR1 axis as a novel biomarker that inhibited the proliferation and invasion of hepatocellular carcinoma, affecting the ultimate disease outcome.

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Section: Discussionmentioning

confidence: 99%

lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation

et al. 2022

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“…An increasing number of studies have reported that the sensitivity of tumor cells to anticancer drugs can be altered by miRNAs (43)(44)(45). miR-34a was reported to enhance the chemosensitivity of PC3 cells to paclitaxel and camptothecin and PCa cells treated with miR-143 showed higher chemosensitivity to docetaxel (37,46).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑122 regulates docetaxel resistance of prostate cancer cells by regulating <em>PKM2</em>

2020

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Prostate cancer (PCa), an epithelial malignancy that occurs in the prostate, is the second leading cause of cancer death worldwide. MicroRNAs (miRs/miRNAs) are reported to have important applications in the field of cancer diagnosis and treatment. The present study aimed to investigate the function of miRNA-122 in the chemoresistance of PCa cells and the underlying mechanism. Significantly decreased miR-122 and increased pyruvate kinase (PKM2) levels were observed in docetaxel-resistant PCa cells, and PKM2 was negatively correlated with miR-122. MiR-122 mimic transfection in docetaxel-resistant LNCaP cells significantly inhibited cell proliferation, promoted apoptosis and decreased glucose uptake and lactate production, which was counteracted by PKM2 overexpression. Inhibition of miR-122 in LNCaP cells had an opposite effect to miR-122 mimic transfection. In addition, miR-122 mimic transfection significantly increased the sensitivity of docetaxel-resistant LNCaP cells to docetaxel, while inhibition of miR-122 significantly decreased the sensitivity of LNCaP cells to docetaxel. Luciferase reporter assays showed that miR-122 regulated PKM2 expression by binding to the 3'-untranslated region of PKM2. The results suggest that upregulation of miR-122 could enhance docetaxel sensitivity, inhibit cell proliferation and promote apoptosis in PCa cells,possibly through the downregulation of its target protein PKM2.

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“…Furthermore, suppressing of miR-765 diminished expression of P-gp, LRP, MRP1, and MDR related genes in SGC7901/VCR. Besides, inhibition of miR-765 accumulated cells in G0/G1 phase and induced apoptosis in SGC7901/VCR cells [80]. Previous evidence has revealed that overexpression of Zinc Finger Protein 139 (ZNF139) is related to GC MDR.…”

Section: The Effect Of Mirnas On Multidrug Resistancementioning

confidence: 99%

Current perspectives on the dysregulated microRNAs in gastric cancer

et al. 2020

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Since gastric cancer (GC) is diagnosed at advanced stages, the survival rate is low in affected people. In this regard, investigating the mechanisms underlying GC development, are so critical. MiRNAs, which are small non coding RNAs, as a post transcriptional repressor, regulate expression of target genes by stimulating breakage or transcription suppression of their targets therefore aberrant expression of miRNAs leading to GC carcinogenesis. In the last decades, there have been various studies approving the pivotal role of miRNAs in various phases of GC development including cancer initiation, proliferation, migration, invasion, metastasis, angiogenesis, apoptosis, and drug resistance. Therefore, the present review aimed at summarizing the dysregulated miRNAs which contribute to various cellular and developmental mechanisms such as, proliferation, apoptosis, invasion, migration, and angiogenesis. Moreover, it provides an overview on novel miRNAs involved in drug resistance and circular miRNAs as cancer biomarkers. Thereafter, it is hoped that the present study will shed more light on diagnostic and prognostic biomarkers of GC, and potential GC treatments based on miRNAs.

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miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells

Cited by 17 publications

References 24 publications

lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation

lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation

MicroRNA‑122 regulates docetaxel resistance of prostate cancer cells by regulating <em>PKM2</em>

Current perspectives on the dysregulated microRNAs in gastric cancer

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