miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts

Read, Danielle E.; Gupta, Ananya; Ladilov, Yury; Samali, Afshin; Gupta, Sanjeev

doi:10.1186/2045-3701-4-56

Cited by 34 publications

(38 citation statements)

References 40 publications

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“…Only recently, the relevance for functional miRNA processing in ER stress has been described (22,32). While in its infancy, research on how miRNA impact mechanisms that underlie the adaptive/apoptotic UPR-switch clearly indicate a crucial part for miRNAs in regulating the complex UPR signaling.…”

Section: Discussionmentioning

confidence: 99%

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Azzouzi

Vilaça

Feyen

et al. 2020

Front. Cardiovasc. Med.

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Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processing, rendering ADAR1 essential for life. Methods and Results:To investigate whether maintenance of ADAR1 expression is required for normal myocardial homeostasis, we bypassed the early embryonic lethality of ADAR1-null mice through the use of a tamoxifen-inducible Cre recombinase under the control of the cardiac-specific α-myosin heavy chain promoter (αMHC). Targeted ADAR1 deletion in adult mice caused a significant increase in lethality accompanied by severe ventricular remodeling and quick and spontaneous cardiac dysfunction, induction of stress markers and overall reduced expression of miRNAs. Administration of a selective inhibitor of the unfolded protein response (UPR) stress significantly blunted the deleterious effects and improved cardiac function thereby prolonging animal survival. In vitro restoring miR-199a-5p levels in cardiomyocytes lacking ADAR1 diminished UPR activation and concomitant apoptosis. Conclusions:Our findings demonstrate an essential role for ADAR1 in cardiomyocyte survival and maintenance of cardiac function through a mechanism that integrates ADAR1 dependent miRNA processing and the suppression of UPR stress.

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Section: Discussionmentioning

confidence: 99%

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Azzouzi

Vilaça

Feyen

et al. 2020

Front. Cardiovasc. Med.

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“…ER stress may cause a decrease in stability of mRNAs or microRNAs, thereby indirectly regulating the protein expression of target genes. Much evidence points toward an overlap between microRNA deregulation and increased ER stress during cardiovascular pathologies (Read et al 2014).…”

Section: R a F T 2012bmentioning

confidence: 99%

Endoplasmic reticulum and the microRNA environment in the cardiovascular system

Groenendyk

Fan

Peng

et al. 2019

Can. J. Physiol. Pharmacol.

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Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.

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“…Cdr1as promotes apoptosis and MI injury by blocking the activity of mir-7a and increasing the expression of mir-7a targets such as PARP and SP1 [58][59][60].…”

Section: Cdr1asmentioning

confidence: 99%

CircRNA: as a disease marker potential and research strategy

Zhou

Ponnusamy

et al. 2018

Preprint

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Circular RNA (CircRNA) is an endogenous noncoding RNA with covalently closed cyclic structure. It is divided into exonic circRNA, intronic circRNA and exon-intron circRNA, based on their components. CircRNAs are well conserved in sequence and abundantly expressed in a tissue specific manner. They have a high stability due to resistance to exonuclease. Depends on their sequence, they perform many biological function including microRNA sponging activity, modulation of alternative splicing or transcription, interaction with RNA binding proteins, rolling translation and derivative of pseudogenes. They are involved in the development of a variety pathological condition including cardiovascular disease, diabetes, neurological diseases and cancer. Emerging evidences show that circRNA are likely to be potential targets for new clinical diagnostic markers or treatment of many diseases. In this review, we have described the potential relationship between circRNA and disease progression, methods and databases of cyclic RNA.

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miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts

Cited by 34 publications

References 40 publications

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Endoplasmic reticulum and the microRNA environment in the cardiovascular system

CircRNA: as a disease marker potential and research strategy

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