MIS-C patients who were reinfected with SARS-CoV-2. Report of 2 cases

Soysal, Ahmet; Topçu, Burcu; Atıcı, Serkan; Gönüllü, Erdem; Öner, Cevat N

doi:10.5546/aap.2022-02893.eng

Cited by 1 publication

(2 citation statements)

References 6 publications

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“…Children, after multiple exposures to SARS-CoV-2, are able to induce a population of immune cells ready to initiate mature humoral and cellular response. These may explain not only the drop in the incidence of MIS-C, but also the reason MIS-C has not been shown to recur with reinfection with SARS-CoV-2 [ 55 , 56 ].…”

Section: What Is Contributing To the Change In Mis-c Features Over Time?mentioning

confidence: 99%

“…Eventually, both vaccines and natural infection induce T cells that recognize VOCs by cross-reacting with intracellular epitopes [ 55 ]. It is worth wondering why antibodies show a loss of efficacy against different VOCs in adults with symptomatic COVID-19 but are still able to prevent MIS-C [ 56 ].…”

Section: What Is Contributing To the Change In Mis-c Features Over Time?mentioning

confidence: 99%

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Exploring Factors Influencing Changes in Incidence and Severity of Multisystem Inflammatory Syndrome in Children

Castaldo,

d’Alanno,

Biserni

et al. 2023

Pathogens

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Multisystem inflammatory syndrome (MIS-C) is a rare condition associated with COVID-19 affecting children, characterized by severe and aberrant systemic inflammation leading to nonspecific symptoms, such as gastrointestinal, cardiac, respiratory, hematological, and neurological disorders. In the last year, we have experienced a progressive reduction in the incidence and severity of MIS-C, reflecting the worldwide trend. Thus, starting from the overall trend in the disease in different continents, we reviewed the literature, hypothesizing the potential influencing factors contributing to the reduction in cases and the severity of MIS-C, particularly the vaccination campaign, the spread of different SARS-CoV-2 variants (VOCs), and the changes in human immunological response. The decrease in the severity of MIS-C and its incidence seem to be related to a combination of different factors rather than a single cause. Maturation of an immunological memory to SARS-CoV-2 over time, the implication of mutations of key amino acids of S protein in VOCs, and the overall immune response elicited by vaccination over the loss of neutralization of vaccines to VOCs seem to play an important role in this change.

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Section: What Is Contributing To the Change In Mis-c Features Over Time?mentioning

confidence: 99%

Section: What Is Contributing To the Change In Mis-c Features Over Time?mentioning

confidence: 99%

Exploring Factors Influencing Changes in Incidence and Severity of Multisystem Inflammatory Syndrome in Children

Castaldo,

d’Alanno,

Biserni

et al. 2023

Pathogens

View full text Add to dashboard Cite

show abstract

MIS-C patients who were reinfected with SARS-CoV-2. Report of 2 cases

Cited by 1 publication

References 6 publications

Exploring Factors Influencing Changes in Incidence and Severity of Multisystem Inflammatory Syndrome in Children

Exploring Factors Influencing Changes in Incidence and Severity of Multisystem Inflammatory Syndrome in Children

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