Miscellaneous treatments, II: niacin and heparin: unapproved uses, dosages, or indications

Wolf, Ronni; Orion, Edith; Matz, Hagit; Tüzün, Yalçın; Tüzün, Binnur

doi:10.1016/s0738-081x(02)00268-7

Cited by 10 publications

(10 citation statements)

References 107 publications

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“…G6PD deficiency causes increased susceptibility of erythrocytes to H 2 O 2 and other reactive oxygen species that can lead to hemolytic anemia, favism (especially in G6PD Mediterranea), chronic non-spherocytic hemolysis, spontaneous abortions (Toncheva and Tzoneva 1985), and neonatal hyperbilirubinemia resulting in neonatal kernicterus (Beutler 1994). Numerous drugs and chemicals, such as primaquine and dapsone (DeGowin et al 1966;Clyde 1981;Wolf et al 2002;Mason et al 2007), ingestion of fava beans, and stress (for example, infection) can induce hemolytic anemia in G6PD-deficient individuals (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women

Peters

Noorden

2009

J Histochem Cytochem.

126

121

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a X-chromosomally transmitted disorder of the erythrocyte that affects 400 million people worldwide. Diagnosis of heterozygously-deficient women is complicated: as a result of lyonization, these women have a normal and a G6PD-deficient population of erythrocytes. The cytochemical assay is the only reliable assay to discriminate between heterozygously-deficient women and non-deficient women or homozygously-deficient women. G6PD deficiency is mainly found in areas where malaria is or has been endemic. In these areas, malaria is treated with drugs that can cause (severe) hemolysis in G6PD-deficient individuals. A cheap and reliable test is necessary for diagnosing the deficiency to prevent hemolytic disorders when treating malaria. In this review, it is concluded that the use of two different tests for diagnosing men and women is the ideal approach to detect G6PD deficiency. The fluorescent spot test is inexpensive and easy to perform but only reliable for discriminating hemizygous G6PD-deficient men from non-deficient men. For women, the cytochemical assay is recommended. However, this assay is more expensive and difficult to perform and should be simplified into a kit for use in developing countries.

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Section: Introductionmentioning

confidence: 99%

Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women

Peters

Noorden

2009

J Histochem Cytochem.

126

121

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“…4,4'-Diaminodiphenylsulfone (DDS, Dapsone), synthesized a century ago, continues to be used in the therapy of many skin diseases (Wolf et al, 2002) and has been the mainstay drug for treating patients with Hansen's disease. However, the mode of action of DDS has not been definitively established.…”

Section: Introductionmentioning

confidence: 99%

Suppression of ROS generation by 4,4'-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts

et al. 2010

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The action mode of 4,4'-diaminodiphenylsulfone (DDS) is still under debate, although it has long been used in treatment of several dermatologic diseases including Hansen's disease. In this study, we tested the effect of DDS as an antioxidant on paraquat-induced oxidative stress in non-phagocytic human diploid fibroblasts (HDFs). Overall, preincubation of HDFs with DDS prevented the oxidative stress and the resulting cytotoxic damages caused by paraquat in these cells. The specific effects of DDS in paraquat-treated HDFs are summarized as follows: a) reducing the expression of NADPH oxidase 4 (NOX4) by inhibiting paraquat-induced activation of PKC; b) inhibiting paraquat-induced decreases in mitochondrial complex protein levels as well as in membrane potentials; c) consequently, inhibiting the generation of cytosolic and mitochondrial superoxide anions. Taken together, these findings suggest that DDS would suppress the radical generation in non-phagocytic HDFs during oxidative stress, and that DDS might have the extended potential to be used further in prevention of other oxidative stress-related pathologies.

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“…22) Another interesting class are diarylsulfones which are important intermediates in organic synthesis because of their chemical properties and biological activities being known especially as antibacterial agents. 23,24) The importance of fluorine atom in medicinal chemistry has been demonstrated by a great number of fluorinated compounds. Introduction of this atom into a molecule of organic compounds, may lead to significant changes in biological and physical properties of these because of their higher metabolic stability, often increased lipophilicity and membrane permeability.…”

mentioning

confidence: 99%

Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class

Bărbuceanu

Drăghici

Bărbuceanu

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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Miscellaneous treatments, II: niacin and heparin: unapproved uses, dosages, or indications

Cited by 10 publications

References 107 publications

Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women

Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women

Suppression of ROS generation by 4,4'-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts

Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class

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