Miscibility and Interactions in Poly(<i>N</i>-acryloylthiomorpholine)/Poly(<i>p</i>-vinylphenol) Blends

Yi, Ju-Zhen; Goh, S. H.; Wee, Andrew Thye Shen

doi:10.1021/ma010188m

Cited by 18 publications

(10 citation statements)

References 29 publications

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“…1-1 前言嵌段共聚物是將兩種或兩種以上不同化學性質與結構的高分子，將其以共價鍵作為連接來避免巨觀相分離的發生，反之，微相分離的產生可導致多種有序奈米結構的變化，致使在奈米科技上有廣泛的應用 [18,19] ，且在軟質材料中扮演重要的角色，其可自組裝形成各種奈米結構，而自組裝的嵌段共聚物可在光電材料、奈米元件、醫學方面有廣泛的應用範圍，將可整合微機電製程，製備具創新應用之各類新穎奈米薄膜材料 [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] [20,21] 。有鑑於此，Zhao 等人探討 poly(styrene-b-vinyl phenol) (PS-b-PVPh)嵌段共聚物作為帶有氫鍵予體的高分子與數個帶有氫鍵受體的高分子均聚物，如： poly(ethylene oxide) (PEO) 、poly(4-vinyl pyridine) (P4VP) 和 poly(butyl methacrylate) (PBMA)等的混摻系統，而這些均聚物與 PS 是不相容的 [22] 。在以往研究當中， poly(vinylphenol)/poly(4-vinylpyridine) (PVPh/P4VP)的高分子共混摻系統已被廣泛討論，並被歸類為強的氫鍵作用力系統。因 PVPh 具有強的質子予體基團，並從文獻顯示 PVPh 能與許多具質子受體的聚合物互溶，如聚甲基丙烯酸酯(PMMA)，聚醚和聚酯等 [23] [32][33][34] ，或者則是利用引入非共價鍵作用力官能基群的方式，如:氫鍵、π-π 作用力、偶極-偶極作用力等特殊作用力來提高高分子摻合系統之相溶性 [35][36][37] 。使得原本不相溶的高分子混摻，透過導入非共價鍵作用力官能基成份來增強彼此分子間的作用力 [38] 。因此提高高分子聚合物的相溶性使其形成單一相系統，並且確保能有利於高分子混摻物之分子間相互作用力存在於兩結構成分中是尤其重要的。…”

Section: 第一章緒論unclassified

Hydrogen bonding strength effect on self-assembly supramolecular structures of diblock copolymer/homopolymer blends

Tsai

Lin

et al. 2016

Polym. Chem.

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Section: 第一章緒論unclassified

Hydrogen bonding strength effect on self-assembly supramolecular structures of diblock copolymer/homopolymer blends

Tsai

Lin

et al. 2016

Polym. Chem.

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“…If there is intermolecular hydrogen bonding between the hydroxyl group of PEG or MPEG and the carbonyl group of PHB‐HHx, the carbonyl bond energy of PHB‐HHx may be reduced because of the interaction between the H in the hydroxyl group and the O of the carbonyl group. Consequently, the F of the carbonyl group will weaken and the peak might shift to a lower frequency 32, 33. Scheme outlines this mechanism.…”

Section: Resultsmentioning

confidence: 99%

Miscibility and crystallization behavior of poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) and methoxy poly(ethylene glycol) blends

Lim

Noda

2006

J Polym Sci B Polym Phys

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Poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHB‐HHx) and methoxy poly(ethylene glycol) (MPEG) blends were prepared using melt blending. The single glass transition temperature, Tg, between the Tgs of the two components and the negative χ value indicated that PHB‐HHx and MPEG formed miscible blends over the range of compositions studied. The Gordon–Taylor equation proved that there was an interaction between PHB‐HHx and MPEG in their blends. FTIR supported the presence of hydrogen bonding between the hydroxyl group of MPEG and the carbonyl group of PHB‐HHx. The spherulitic morphology and isothermal crystallization behavior of the miscible PHB‐HHx/MPEG blends were investigated at two crystallization temperatures (70 and 40 °C). At 70 °C, melting MPEG acted as a noncrystalline diluent that reduced the crystallization rate of the blends, while insoluble MPEG particles acted as a nucleating agent at 40 °C, enhancing the crystallization rate of the blends. However, no interspherulitic phase separation was observed at the two crystallization temperatures. The constant value of the Avrami exponent demonstrated that MPEG did not affect the three‐dimensional spherulitic growth mechanism of PHB‐HHx crystals in the blends, although the MPEG phase, such as the melting state or insoluble state, influenced the crystallization rate of the blends. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 2852–2863, 2006

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“…All chemicals and solvents were purchased from Sigma-Aldrich, Carl Roth, Acros Organics, and Thermofisher Scientific and used without further purification unless mentioned otherwise. Vinyldimethylazlactone (VDM) and NAT were synthesized following literature known procedures. 2-(Butylthiocarbonothioylthio)propanoic acid (PABTC) was prepared as previously reported .…”

Section: Methodsmentioning

confidence: 99%

Influence of Core Cross-Linking and Shell Composition of Polymeric Micelles on Immune Response and Their Interaction with Human Monocytes

et al. 2020

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Block copolymer micelles have received increasing attention in the last decades, in particular for their appealing properties in nanomedicine. However, systematic investigations of the interaction between polymeric micelles and immune cells are still rare. Therefore, broader studies comparing the structural effects remain inevitable for a comprehensive understanding of the immune response and for the design of efficient, nonimmunogenic delivery systems. Here, we present novel block copolymer micelles with the same hydrophobic core, based on a copolymer of BA and VDM, and various hydrophilic shells ranging from common PEG derivatives to morpholine-based materials. The influence of these shells on innate immune responses was studied in detail. In addition, we investigated the impact of micelle stability by varying the cross-linking density in the micellar core. Surprisingly, whereas different shells had only a minor impact on immune response, micelles with reduced cross-linking density considerably enhanced the release of cytokines from isolated human monocytes. Moreover, the uptake of non-cross-linked micelles by monocytes was significantly higher as compared to cross-linked materials. Our study emphasizes the importance of the micellar stability on the interaction with the immune system, which is the key for any stealth properties in vivo. Polymers based on morpholines result in a similar low response as the PEG derivative and may represent an interesting alternative to the common PEGylation.

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Miscibility and Interactions in Poly(N-acryloylthiomorpholine)/Poly(p-vinylphenol) Blends

Cited by 18 publications

References 29 publications

Hydrogen bonding strength effect on self-assembly supramolecular structures of diblock copolymer/homopolymer blends

Hydrogen bonding strength effect on self-assembly supramolecular structures of diblock copolymer/homopolymer blends

Miscibility and crystallization behavior of poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) and methoxy poly(ethylene glycol) blends

Influence of Core Cross-Linking and Shell Composition of Polymeric Micelles on Immune Response and Their Interaction with Human Monocytes

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