Misleading Information on the Properties of Vitamin C

Hickey, Steve; Roberts, Hilary

doi:10.1371/journal.pmed.0020307

Cited by 11 publications

(7 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 and has a short half-life (Ϸ30 minutes) in the blood. 8,9 Furthermore, the main source of vitamin C (ascorbic acid) in humans is from food consumption, predominantly fruits and vegetables, because they cannot synthesize ascorbic acid in the body. 7 Therefore, plasma concentration of vitamin C is highly related to the individual's habitual dietary pattern and method of food preparation.…”

mentioning

confidence: 99%

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study

Myint

Luben

Wareham³

et al. 2011

Hypertension

View full text Add to dashboard Cite

Abstract-The effect of fruit and vegetable consumption and blood pressure is unclear. A population-based cross-sectional study was conducted in 20 926 men and women aged 40 to 79 years participating in the European Prospective Investigation Into Cancer-Norfolk who completed a health questionnaire and attended a clinic from 1993 to 1997. The relationship between plasma vitamin C concentrations, as an indicator of fruit and vegetable intake, and systolic BP was examined. Key Words: blood pressure Ⅲ hypertension Ⅲ ascorbic acid Ⅲ diet Ⅲ antioxidant H ypertension is one of the major risk factors for cardiovascular disease (CVD), 1 which is responsible for a third of global deaths with increasing disease burden attributed to increasing aging of populations across the world. 2 Hypertension has been well recognized as a major risk factor for CVD. The World Health Organization defines hypertension as blood pressure Ն140/90 mm Hg regardless of age or sex. 3 There also appears to be a linear and direct relationship between blood pressure and CVD incidence, as well as mortality. 4 -6 Fresh fruits and vegetables are a richer source of ascorbic acid compared with cooked/boiled fruit and vegetables. Ascorbic acid in the food is also easily destroyed (eg, cooking in water, roasting, or grilling). 7 and has a short half-life (Ϸ30 minutes) in the blood. 8,9 Furthermore, the main source of vitamin C (ascorbic acid) in humans is from food consumption, predominantly fruits and vegetables, because they cannot synthesize ascorbic acid in the body. 7 Therefore, plasma concentration of vitamin C is highly related to the individual's habitual dietary pattern and method of food preparation. Although randomized trials indicate that supplementation with antioxidant vitamins including ␤-carotene, vitamin E, or vitamin C does not reduce cardiovascular risk, 10,11 prospective studies indicate that high fruit and vegetable intake, of which plasma vitamin C is a good biomarker, is inversely related to mortality and incident CVD, especially stroke. [12][13][14] The association between fruit and vegetable intake and blood pressure is less well known. Because hypertension is the major risk factor for stroke, we hypothesize that plasma vitamin C concentrations, which are derived from fruit and vegetable intake, may reduce stroke incidence through blood pressure-lowering effect. Therefore, in this study, we explored the cross-sectional association between plasma vitamin C concentrations and blood pressure using a large United

show abstract

mentioning

confidence: 99%

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study

Myint

Luben

Wareham³

et al. 2011

Hypertension

View full text Add to dashboard Cite

show abstract

“…A Bayesian approach enables the inclusion of Hill's criteria directly into assessment of epidemiological evidence. With ascorbate the short excretion half-life of single doses above ,200 mg, of 30 minutes, can be used to evaluate otherwise invalid epidemiological claims [22]. Using a Bayesian decision-theoretic approach would include weighing the claimed benefits of high doses of ascorbate, which include reductions in heart disease and cancer, against putative risks.…”

Section: Example Of the Bayesian Approachmentioning

confidence: 99%

Nutrient risk assessment in a decision theoretic context

Hickey

Downing²,

Verkerk³

et al. 2008

Journal of Nutritional & Environmental Medicine

View full text Add to dashboard Cite

Background. This study describes a decision-theoretic approach to nutrient assessment based on Bayesian methods, which can be used to give accurate estimates of optimum intakes. Analysis of risk is an incomplete technique for dealing with nutrients and other substances that, by definition, have an associated benefit.Results. This paper shows that the risk analysis methods being developed by the Codex Commission on Nutrition and European Food Safety Authority, among others, are inappropriate for assessing safe nutrient intake levels. Decision theoretic methods incorporate benefits associated with these essential nutrients, as well as potential risk. Conclusion. These methods allow for missing or incomplete data, which conventional risk analysis does not.

show abstract

“…via cooking in water, roasting, or grilling) [8]. It also has a short half-life (≈30 min) in the blood [9,10]. Therefore, random plasma vitamin C level is most likely to reflect an individual's habitual dietary pattern as well as method of food preparation.…”

Section: Introductionmentioning

confidence: 99%

Plasma vitamin C concentrations and risk of incident respiratory diseases and mortality in the European Prospective Investigation into Cancer-Norfolk population-based cohort study

et al. 2019

View full text Add to dashboard Cite

Background: Cancerous and non-cancerous respiratory diseases are common and contribute significantly to global disease burden. We aim to quantify the association between plasma vitamin C concentrations as an indicator of high fruit and vegetable consumption and the risk of incident respiratory diseases and associated mortality in a general population. Methods: 19,357 men and women aged 40-79 years without prevalent respiratory diseases at the baseline (1993-1997) and participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk study in the UK were followed through March 2015 for both incidence and mortality from respiratory diseases. Results: There were a total of 3914 incident events and 407 deaths due to any respiratory diseases (excluding lung cancers), 367 incident lung cancers and 280 lung cancer deaths during the follow up (total person years >300,000 years). Cox proportional hazards models showed, persons in the top quartiles of baseline plasma vitamin C concentrations had a 43% lower risk of lung cancer (HR 0.57; 95%CI:0.41-0.81) than did those in the bottom quartile, independently of potential confounders. The results are similar for non-cancerous any respiratory disease (HR 0.85;0.77-0.95), chronic respiratory diseases (HR0.81;0.69-0.96), and pneumonia (HR0.70;0.59-0.83). The corresponding values for mortality were 0.54(0.35-0.81), 0.81(0.59-1.12), 0.85(0.44-1.66), and 0.61(0.37-1.01), respectively. Confining analyses to non-smokers showed 42% and 53% risk reduction of non-smoking related lung cancers incidence and death. Conclusions: Higher levels of vitamin C concentrations as a marker of high fruit and vegetable consumption reduces the risk of cancerous and non-cancerous respiratory illnesses including non-smoking related cancers incidence and deaths.

show abstract

Misleading Information on the Properties of Vitamin C

Cited by 11 publications

References 9 publications

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study

Nutrient risk assessment in a decision theoretic context

Plasma vitamin C concentrations and risk of incident respiratory diseases and mortality in the European Prospective Investigation into Cancer-Norfolk population-based cohort study

Contact Info

Product

Resources

About