Misuse of ecstasy.

Shearman, J. D.; Chapman, Rachel; Satsangi, Jack; Ryley, N. G.; Weatherhead, Stephen

doi:10.1136/bmj.305.6848.309

Cited by 36 publications

(10 citation statements)

References 4 publications

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“…Ring substituted phenethylamines are known to alter thermoregulation and their use at raves and other dances appeared to be an important component in the UK deaths. Hepatitis, fibrosis and fulminant liver failure were also identified [19][20][21][22][23][24][25]. Cases of water intoxication, some fatal, were also encountered [2,[26][27].…”

Section: Discussionmentioning

confidence: 98%

Deaths associated with MBDB misuse

Carter

Rutty

Milroy

et al. 2000

International Journal of Legal Medicine

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The use of phenethylamines in the dance scene is now well established. Apart from amphetamine, the commonest phenethylamine encountered in clinical and forensic settings is 3,4-methylenedioxymethamphetamine (MDMA) commonly known as ecstasy. Other phenethylamines, which have similar effects are encountered, such as 3,4-methylenedioxyethylamphetamine (MDEA) and their use has resulted in death. We report two deaths associated with another less commonly encountered member of the group, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), also known as Methyl-J and Eden.

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Section: Discussionmentioning

confidence: 98%

Deaths associated with MBDB misuse

Carter

Rutty

Milroy

et al. 2000

International Journal of Legal Medicine

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“…Liver biopsy, where performed (Shearman et al,8 Gorard et al 9 and case three in this report), showed evidence of acute hepatitis with lobular disarray and centrilobular drop out of hepatocytes. Recovery from the hepatic insult takes place over a variable amount of time, from three weeks to three months.…”

Section: Discussionmentioning

confidence: 54%

“…4 The peak bilirubin concentrations in our patients varied from 75 ,umol/l to 371 pumol/l and the peak aspartate aminotransferase from 639 to 1410 U/1 in case three and two respectively (Table). Liver biopsy, where performed (Shearman et al,8 Gorard et al 9 and case three in this report), showed evidence of acute hepatitis with lobular disarray and centrilobular drop out of hepatocytes. Recovery from the hepatic insult takes place over a variable amount of time, from three weeks to three months.…”

Section: Discussionmentioning

confidence: 99%

Ecstasy induced hepatitis mimicking viral hepatitis.

Dykhuizen

Brunt

Atkinson

et al. 1995

Gut

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“…No entanto, existem vários relatos científicos confirmando o contrário, ou seja, que o "êxtase" não é uma droga segura podendo, inclusive, ser fatal. É uma droga de abuso e se deve prevenir mais fortemente o início de uso por crianças e adolescentes 37,41 .…”

Section: Como é Usado O "êXtase"unclassified

"Êxtase": revisão farmacológica

1998

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Neste estudo fez-se uma revisão bibliográfica sobre a 3,4- metilenodioximetan-fetamina (MDMA), mais conhecida como "êxtase", uma droga em expansão de abuso entre os jovens. Descreve-se o histórico, desde sua síntese até seu uso inicial como auxiliar em psicoterapia e, mais recentemente, como droga de abuso. Apresenta-se o perfil de uso em outros países, tentando prever o possível padrão de uso no Brasil, onde já se iniciou o abuso. O detalhamento sobre a farmacocinética da MDMA visa a justificar as conseqüências sobre a atividade farmacológica e toxicológica. Resumem-se as manifestações clínicas de toxicidade a curto e a médio prazo, descrevendo-se os efeitos na intoxicação grave com o "êxtase". São apresentados os estudos dos mecanismos de ação no sentido de justificar seus efeitos tóxicos psíquicos e físicos, detalhar os mecanismos pelos quais a droga é auto-administrada e as possibilidades terapêuticas para reverter os efeitos.

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Misuse of ecstasy.

Cited by 36 publications

References 4 publications

Deaths associated with MBDB misuse

Deaths associated with MBDB misuse

Ecstasy induced hepatitis mimicking viral hepatitis.

"Êxtase": revisão farmacológica

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