Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain

Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad; Latifi, Ali Mohammad; Mirzaei, Morteza; Habtemariam, Solomon; Moghaddam, Akbar Hajizadeh

doi:10.3109/13880209.2012.675341

Cited by 31 publications

(10 citation statements)

References 16 publications

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“…As shown in Table 1, the water extract showed antioxidant activity comparable with the methanol extract (p > 0.05). The validation of antioxidant potential of herbal medicines in our laboratories is based on several in-house in vitro cell-free and cell-based assays [33][34][35][36][37][38][39][40][41][42][43][44] as well as in vivo models [45][46][47][48][49][50][51][52][53][54]. Since the principal active constituent of the methanol and water extracts of M. stenopetala leaves is the well-characterised antioxidant and bioactive agent rutin, further biological bioassays on the extracts were not necessary.…”

Section: Methodsmentioning

confidence: 99%

Extractability of Rutin in Herbal Tea Preparations of Moringa stenopetala Leaves

Habtemariam¹,

Varghese²,

Chambers³

2015

Beverages

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The study examined the comparative rutin contents and antioxidant potentials of the two closely related Moringa species: the Ethiopian (Moringa stenopetala) and Indian Moringa (M. oleifera). It is demonstrated that M. stenopetala leaves extract was a far superior (more than five-fold better) antioxidant than M. oleifera. Rutin was the principal constituent of M. stenopetala leaves while the compound was not detected in the leaves of M. oleifera. Quantitative HPLC-based analysis of M. stenopetala leaves revealed the rutin level at a respectable 2.34% ± 0.02% (on dry weight basis), which is equivalent to many commercial natural sources of this highly sought-after bioactive compound. Comparative analysis of rutin in some common herbal tea preparations of M. stenopetala leaves revealed that it is readily extractible with the highest amount obtained (98.8% ± 2.4%) when the leaves (1 g) were boiled in water (200 mL). For a large-scale exploitation of rutin, a fast and economically-viable isolation approach using solid phase extraction followed by crystallization or flash chromatography is outlined. Overall, the Ethiopian Moringa is distinctively different from the Indian Moringa and could be exploited as an industrial source of rutin for nutritional and/or medical uses.

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Section: Methodsmentioning

confidence: 99%

Extractability of Rutin in Herbal Tea Preparations of Moringa stenopetala Leaves

Habtemariam¹,

Varghese²,

Chambers³

2015

Beverages

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“…The spatial arrangement and total number of hydroxyl groups located at the B-ring have been postulated to account for the antioxidant potency of quercetin [20]. In addition to the direct antioxidative action, quercetin also protects mitochondrial function [25] and regulates enzyme antioxidative defense systems [26]–[28]. It has been reported that quercetin protected Caco-2 cells against indomethacin-induced mitochondrial dysfunction [25].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Quercetin on the Development of Preimplantation Mouse Embryos against Hydrogen Peroxide-Induced Oxidative Injury

Long

Lyu

et al. 2014

PLoS ONE

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Quercetin, a plant-derived flavonoid in Chinese herbs, fruits and wine, displays antioxidant properties in many pathological processes associated with oxidative stress. However, the effect of quercetin on the development of preimplantation embryos under oxidative stress is unclear. The present study sought to determine the protective effect and underlying mechanism of action of quercetin against hydrogen peroxide (H2O2)-induced oxidative injury in mouse zygotes. H2O2 treatment impaired the development of mouse zygotes in vitro, decreasing the rates of blastocyst formation and hatched, and increasing the fragmentation, apoptosis and retardation in blastocysts. Quercetin strongly protected zygotes from H2O2-induced oxidative injury by decreasing the reactive oxygen species level, maintaining mitochondrial function and modulating total antioxidant capability, the activity of the enzymatic antioxidants, including glutathione peroxidase and catalase activity to keep the cellular redox environment. Additionally, quercetin had no effect on the level of glutathione, the main non-enzymatic antioxidant in embryos.

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“…Various phytochemicals have been reported to have antioxidant activity against fluoride-induced oxidative stress. Thymoquinone 48 , quercetin 49 and lycopene 50 etc. have been found to be beneficial against sodium-fluoride induced toxicity in liver, brain, red blood cells and cardiac tissue of rats.…”

Section: Effect Of Fluoride On Brain Variables Suggestive Of Oxidativmentioning

confidence: 99%

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2014

IJPSR

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Increased production of reactive oxygen species plays important role in pathogenesis of chronic fluoride toxicity resulting from prolonged exposure to fluoride. Oral (NaF) fluoride administration to rats at 20 mg/kg b.w./day for 30 days resulted in elevation in MDA, free amino acid N 2 , NO level and decreased activities of SOD, GPx, CAT, GR and reduced non enzymatic antioxidant like GSH. Significant alteration in protein and nucleic acid metabolism in discrete brain regions was observed associated with altered activities of proteolytic and transaminase enzymes in treated animals. Neanotis wightiana is traditionally used by local people of Tripura for brain and liver disorders. 3α-hydroxy olean-12-en-27-oic acid isolated from the plant was administered to rats at a dose of 5 mg/kg b.w./day orally for the last 14 days of fluoride exposure in order to elucidate the antioxidative role of this triterpenoid compound in brain protein and nucleic acid metabolism during toxic insult. The present study indicates that the compound appreciably prevented NaF-induced changes in above mentioned parameters in rat brain by antagonizing the free radical generation and enhancing the antioxidant defence power of brain tissue. QUICK RESPONSE CODE

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Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain

Cited by 31 publications

References 16 publications

Extractability of Rutin in Herbal Tea Preparations of Moringa stenopetala Leaves

Extractability of Rutin in Herbal Tea Preparations of Moringa stenopetala Leaves

Protective Effect of Quercetin on the Development of Preimplantation Mouse Embryos against Hydrogen Peroxide-Induced Oxidative Injury

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