Mitigation of Colitis with NovaSil Clay Therapy

Abstract

NovaSil mitigated the effects of TNBS-induced colitis based on reduction in systemic markers of inflammation, significant improvement in weight gain, and intestinal microbial profile.

Chemotherapy‐induced diarrhoea in dogs and its management with smectite: Results of a monocentric open‐label randomized clinical trial

“…Although the mechanism of action of smectite is not clearly understood, it is an activated natural aluminosilicate clay that can adsorb water and presents multiple other interesting properties: it prevents toxins, bacteria and viruses adhering to intestinal membranes, 9,13‐17 it has been shown to strengthen the mucosal barrier in vitro and in vivo, 18‐20 to have some anti‐inflammatory properties, 17,18,21,22 to decrease intestinal bacterial translocation 23 and to stabilize the intestinal microbiome 16,17 …”

“…Its role in the treatment of acute diarrhoea in children and adults is well established, 24,25 and a beneficial effect has been found in different types of diarrhoea and different species 21,22,26‐28 . In a case series of 17 dogs with intractable CID, 10 dogs (58.8%) had resolution of their diarrhoea after 48 to 72 hours of treatment, and improvement was noted in the remainder 29…”

Probiotic co-supplementation with absorbent smectite for pancreatic beta-cell function in type 2 diabetes: a secondary-data analysis of a randomized double-blind controlled trials

“…Smectite has been effectively used in the treatment of several gastrointestinal diseases, including infectious diarrhea and food allergy (37). In experimental colitis models was found that administration of smectite associated with absorption of inflammatory proteins, reduction in systemic markers of inflammation (IL-2, IL-6, IL-8 and IL-12, TNFa, IFNg) (38)(39)(40) and significant improvement in intestinal microbial profile (41). The Dening et al proposed that spray dried smectite clay particles may be developed as novel antiobesity treatments (42,43).…”

Fructose Increases Uric Acid Contributing to Metabolic Syndrome - Herbal, Nutritional and Dietary Strategies to Reduce Uric Acid

“…In mice, montmorillonite (bentonite) clay adsorbs uric acid and promotes the diffusion of uric acid from blood vessels to intestine, prevents absorption of uric acid in intestine and decreases SUA [141]. In mice with induced colitis, the processed calcium montmorillonite clay product, Novasil, reduced systemic markers of inflammation, and improved both weight gain and the intestinal microbial profile [142]. Aflatoxin levels in the serum and the urine of adults have been reported to decrease following the consumption of Novasil [143], indicating that the clay is acting as an adsorbent in vivo.…”