To study the effect of the radial density profile of the material of a metal-plasma Z-pinch load on the development of magneto-Rayleigh-Taylor (MRT) instabilities, experiments have been performed at the Institute of High Current Electronics with the GIT-12 generator produced microsecond rise time megaampere currents. The load was an aluminum plasma jet with an outer plasma shell. This configuration provides the formation of a uniform current sheath in a Z-pinch load upon application of a high voltage pulse. It was successfully used in experiments with hybrid deuterium gas-puffs [Klir et al. 2020 New J. Phys. 22 103036]. The initial density profiles of the Z-pinch loads were estimated from the pinch current and voltage waveforms using the zero-dimensional "snowplow" model, and they were verified by simulating the expansion of the plasma jet formed by a vacuum arc using a two-dimensional quasi-neutral hybrid model [Shmelev et al. 2020 Phys. Plasmas 27 092708]. Two Z-pinch load configurations were used in the experiments. The first configuration provided tailored load density profiles, which could be described as ρ(r) ≈ 1/r^s for s > 2. In this case, MRT instabilities were suppressed and thus a K-shell radiation yield of 11 kJ/cm and a peak power of 0.67 TW/cm could be attained at a current of about 3 MA. For the second configuration, the radial density profiles were intentionally changed using a reflector. This led to the appearance of a notch in the density profiles at radii of 1–3 cm from the pinch axis and to magnetohydrodynamic instabilities at the final implosion stage. As a result, the K-shell radiation yield more than halved and the power decreased to 0.15 TW/cm at a current of about 3.5 MA.