Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells

Belyaeva, E. S.; Dymkowska, Dorota; Wiêckowski, Mariusz R.; Wojtczak, Lech

doi:10.1016/j.taap.2008.03.017

Cited by 125 publications

(83 citation statements)

References 45 publications

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“…This degree of interaction would, however be sufficient to produce the conformational changes required for activation of the Ca uniporter-mediated cation uptake, and affects mitochondrial permeability transition. The hepatocyte mitochondrion has been considered a major source for Cd-induced ROS production [67]. ROS produced include O 2…”

Section: Mitochondria and Cadmiummentioning

confidence: 99%

Liver and Cadmium Toxicity

2013

J Drug Metab Toxicol

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Section: Mitochondria and Cadmiummentioning

confidence: 99%

Liver and Cadmium Toxicity

2013

J Drug Metab Toxicol

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“…Kupffer cells are activated in response to Cd overload and produce infl ammatory mediators such as IL-1β, TNF-α, IL-6, and IL-8, which in turn stimulate generation of free radicals in the liver (43). It has also been suggested that mitochondria are an important target of Cd toxicity (44).…”

Section: Role Of Cadmium In Oxidative Stress Inductionmentioning

confidence: 99%

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Matović

Buha

Bulat

et al. 2011

Archives of Industrial Hygiene and Toxicology

184

122

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Discovered in late 1817, cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to fi nd out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically effi cient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has benefi cial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These fi ndings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

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“…The Human Cerebrospinal Fluid Metabolome (http://www.csfmetabolome.ca) [3] and the Human Serum Metabolome (http://www.serummetabolome.ca) [12]. These resources have the explicit goal of establishing comprehensive, electronically accessible databases of all the detectable metabolites in human serum and CSF.…”

Section: Nmr Metabolomics Databasesmentioning

confidence: 99%

Databases and Software for NMR-Based Metabolomics

Ellinger¹,

Chylla²,

Ulrich³

et al. 2012

CMB

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New software and increasingly sophisticated NMR metabolite spectral databases are advancing the unique abilities of NMR spectroscopy to identify and quantify small molecules in solution for studies of metabolite biomarkers and metabolic flux. Public and commercial databases now contain experimental 1D 1 H, 13 C and 2D 1 H-13 C spectra and extracted spectral parameters for over a thousand compounds and theoretical data for thousands more. Public databases containing experimental NMR data from complex metabolic studies are emerging. These databases are providing information vital for the construction and testing of new computational algorithms for NMR-based chemometric and quantitative metabolomics studies. In this review we focus on database and software tools that support a quantitative NMR approach to the analysis of 1D and 2D NMR spectra of complex biological mixtures.

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Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells

Cited by 125 publications

References 45 publications

Liver and Cadmium Toxicity

Liver and Cadmium Toxicity

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Databases and Software for NMR-Based Metabolomics

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