Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

Sun, Tingting; Guan, Xingang; Zheng, Min; Jing, Xiabin; Xie, Zhigang

doi:10.1021/acsmedchemlett.5b00041

Cited by 83 publications

(61 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the cytotoxicity of nanomedicines, several parameters could affect their cell viability, including the size, shape and stability. As reported in our previous work, the IC50 values of cisplatin toward HeLa and MCF–7 cells are 1.03 and 2.63 μg/mL, respectively43. Considering the IC50 value, 4 or 8 are less toxic than cisplatin.…”

Section: Resultssupporting

confidence: 64%

Lanthanide-Connecting and Lone-Electron-Pair Active Trigonal-Pyramidal-AsO3 Inducing Nanosized Poly(polyoxotungstate) Aggregates and Their Anticancer Activities

Zhao

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

By virtue of the stereochemical effect of the lone-electron pair located on the trigonal-pyramidal-AsO3 groups and the one-pot self-assembly strategy in the conventional aqueous solution, a series of novel lanthanide-bridging and lone-electron-pair active trigonal-pyramidal-AsO3 inducing nanosized poly(polyoxotungstate) aggregates [H2N(CH3)2]6 Na24H16{[Ln10W16(H2O)30O50](B-α-AsW9O33)8}·97H2O [Ln = EuIII (1), SmIII (2), GdIII (3), TbIII (4), DyIII (5), HoIII (6), ErIII (7), TmIII (8)] were prepared and further characterized by elemental analyses, IR spectra, UV spectra, thermogravimetric (TG) analyses and single-crystal X-ray diffraction. The most remarkable structural feature is that the polyanionic skeleton of {[Ln10W16(H2O)30O50](B-α-AsW9O33)8}46− is constructed from eight trivacant Keggin [B-α-AsW9O33]9− fragments through ten Ln centers and sixteen bridging W atoms in the participation of fifty extraneous oxygen atoms. Notably, 4 and 8 can be stable in the aqueous solution not only for eight days but also in the range of pH = 3.9–7.5. Moreover, the cytotoxicity tests of 4 and 8 toward human cervical cancer (HeLa) cells, human breast cancer (MCF–7) cells and mouse fibroblast (L929) cells were performed by the 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and the cell apoptosis processes were characterized by calcein AM/PI staining experiments, annexin V-FITC/PI staining experiments and morphological changes.

show abstract

Section: Resultssupporting

confidence: 64%

Lanthanide-Connecting and Lone-Electron-Pair Active Trigonal-Pyramidal-AsO3 Inducing Nanosized Poly(polyoxotungstate) Aggregates and Their Anticancer Activities

Zhao

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, Xie et al. reported a novel fluorescent boron dipyrromethene (BODIPY)–platinum conjugate that proved to localize predominantly in the mitochondria, and exhibited high cellular proliferation inhibition against human cervical carcinoma (HeLa) and human breast cancer (MCF‐7) cells 4a. Kim et al.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Coumarin–Artemisinin Conjugates as Mitochondria‐Targeting Theranostic Probes for Enhanced Anticancer Activities

Zhang

et al. 2015

Chemistry A European J

View full text Add to dashboard Cite

Mitochondria-targeting theranostic probes that enable the simultaneously reporting of and triggering of mitochondrial dysfunctions in cancer cells are highly attractive for cancer diagnosis and therapy. Three fluorescent mitochondria-targeting theranostic probes have been developed by linking a mitochondrial dye, coumarin-3-carboximide, with a widely used traditional Chinese medicine, artemisinin, to kill cancer cells. Fluorescence images showed that the designed coumarin-artemisinin conjugates localized mainly in mitochondria, leading to enhanced anticancer activities over artemisinin. High cytotoxicity against cancer cells correlated with the strong ability to accumulate in mitochondria, which could efficiently increase the intracellular reactive oxygen species level and induce cell apoptosis. This study highlights the potential of using mitochondria-targeting fluorophores to selectively trigger and directly visualize subcellular drug delivery in living cells.

show abstract

“…Fluorescence labeling is a versatile method to image the distribution and metabolism of therapeutics in living cells or in vivo . Among various organic dyes, boron‐dipyrromethenes (BODIPY) derivatives have drawn much attention in bioimaging and chemical sensors because of their high quantum yields and outstanding photophysical properties . Furthermore, fluorescent nanoparticles show distinct chemical and optical properties, such as higher photostability and better biocompatibility compared to traditional fluorescent dyes.…”

Section: Methodsmentioning

confidence: 99%

Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy

Sun

Lin

Zhang

et al. 2016

Chemistry An Asian Journal

Self Cite

View full text Add to dashboard Cite

An amphiphilic drug-dye conjugate (PTX-Pt-BDP) was designed and synthesized with a platinum compound as the hydrophilic head. The precursor of PTX-Pt-BDP was obtained under mild conditions by means of a three-component Passerini reaction. PTX-Pt-BDP could self-assemble into nanoparticles (PTX-Pt-BDP NPs) in aqueous solution via a nanoprecipitation method. The obtained nanoparticles exhibited favorable structural stability in both water and physiological environment. PTX-Pt-BDP NPs could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy and exert potent cytotoxicity. This work highlights the potential of nanomedicines from amphiphilic drug-dye conjugates for cancer cell imaging and chemotherapy.

show abstract

Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

Cited by 83 publications

References 38 publications

Lanthanide-Connecting and Lone-Electron-Pair Active Trigonal-Pyramidal-AsO3 Inducing Nanosized Poly(polyoxotungstate) Aggregates and Their Anticancer Activities

Lanthanide-Connecting and Lone-Electron-Pair Active Trigonal-Pyramidal-AsO3 Inducing Nanosized Poly(polyoxotungstate) Aggregates and Their Anticancer Activities

Fluorescent Coumarin–Artemisinin Conjugates as Mitochondria‐Targeting Theranostic Probes for Enhanced Anticancer Activities

Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy

Contact Info

Product

Resources

About