2013
DOI: 10.1016/j.yjmcc.2013.01.016
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Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure

Abstract: Trimetazidine (TMZ) is used successfully for treatment of ischemic cardiomyopathy, however its therapeutic potential in heart failure (HF) remains to be established. While the cardioprotective action of TMZ has been linked to inhibition of free fatty acid oxidation (FAO) via 3-ketoacyl CoA thiolase (3-KAT), additional mechanisms have been suggested. The aim of this study was to evaluate systematically the effects of TMZ on calcium signaling and mitochondrial function in a rabbit model of non-ischemic HF and to… Show more

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Cited by 70 publications
(61 citation statements)
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“…S6B), showing that firstly, negative controls without any substrate are essential to determine that any significant signal is not independent of mitochondrial respiration and secondly, that succinate together with SA drives enhanced H 2 O 2 production. This demonstrates that complex II can act as a major source of ROS production with higher rates than complex I,III or alternative NADH dehydrogenases, a phenomenon that has previously be shown in mammalian mitochondria where SDH was found to produce the highest amounts of ROS (Dedkova et al, 2013;Quinlan et al, 2012;Ralph et al, 2011) and recently in barley (Hordeum vulgare) roots, where complex II-derived ROS was shown to be the major source of mitochondrial ROS during mercury toxicity (Tamás and Zelinová, 2017).…”
Section: Sa Stimulates Sdh-dependent H 2 O 2 Productionsupporting
confidence: 61%
“…S6B), showing that firstly, negative controls without any substrate are essential to determine that any significant signal is not independent of mitochondrial respiration and secondly, that succinate together with SA drives enhanced H 2 O 2 production. This demonstrates that complex II can act as a major source of ROS production with higher rates than complex I,III or alternative NADH dehydrogenases, a phenomenon that has previously be shown in mammalian mitochondria where SDH was found to produce the highest amounts of ROS (Dedkova et al, 2013;Quinlan et al, 2012;Ralph et al, 2011) and recently in barley (Hordeum vulgare) roots, where complex II-derived ROS was shown to be the major source of mitochondrial ROS during mercury toxicity (Tamás and Zelinová, 2017).…”
Section: Sa Stimulates Sdh-dependent H 2 O 2 Productionsupporting
confidence: 61%
“…In basic medical science, TMZ has been demonstrated to have pleiotropic effects. For example, it inhibits cardiomyocyte apoptosis [26], protects endothelial progenitor cells against H 2 O 2 -induced injury [9], reduces mitochondria-dependent oxidative stress and increases mitochondrial generation of NO [27]. However, it is not known whether TMZ can inhibit the H/SD induced apoptosis of MSCs, particularly MSCs of human origin.…”
Section: Discussionmentioning
confidence: 99%
“…75 In a rabbit model of heart failure, an enhanced electron leak (site of ROS production) at complex II was attenuated and the activity of complex I was increased by trimetazidine. 76 Trimetazidine is an effective anti-ischemic agent in angina patients 77 and reduces intracoronary platelet aggregation. 78 Trimetazidine therapy improved cardiac energetic status in patients with LV systolic dysfunction attributable to dilated cardiomyopathy as assessed by the phosphocreatine/ATP ratio using 31P magnetic resonance spectroscopy.…”
Section: Partial Inhibitors Of Fatty Acid β-Oxidationmentioning
confidence: 99%