Mitochondria-targeted photosensitizer based nanoplatform loading glutathione inhibitor for enhanced breast cancer photodynamic therapy

Three-dimensional Au–MnO2 nanostructure as an agent of synergistic cancer therapy: chemo-/photodynamic and photothermal approaches

“…19,54 The DPBF sensor results demonstrated that Mn 2+ ions can absorb NIR light, and transfer energy directly to oxygen to induce local ROS production and reduce ROS consumption by decreasing intracellular GSH levels. 55 The energy-to-oxygen transfer efficiency of the Au-MnO 2 nanostructures is comparable to that of nonirradiated nanostructures. Briefly, DPBF will react irreversibly with ROS to be bleached under NIR irradiation.…”

Imaging of mitochondria/lysosomes in live cells and C. elegans

“…13 Similarly, a ruthenium peptide 14 or protein conjugate 15 was designed to target mitochondria and study the photoinduced damage selectively. Several other strategies targeting sub-cellular organelles and achieving the photosensitizing action were also demonstrated through a stimulus (hypoxia)-activatable 4-nitrobenzylbromide bearing cyanine dye, 16 NIR-activated mitophagy using a coumarin-based D–π-A system, 17 iridium( iii ) complexes under normoxic and hypoxic conditions, 18 cyanine containing molecular systems, 19 and amphiphilic systems, 20 among others. Considering the methodology and success, we designed a mitochondrial targeting probe by incorporating cationic rhodamine with phenothiazine.…”

Multifunctional Novel Nanoplatform for Effective Synergistic Chemo-Photodynamic Therapy of Breast Cancer by Enhancing DNA Damage and Disruptions of Its Reparation

“…At present, breast cancer (BC) is one of the most commonly malignant tumors that seriously threaten women's health and lives worldwide because of its high morbidity and mortality rates [1][2][3]. Among the many recently investigated breast cancer treatments, photodynamic therapy (PDT) has attracted great interest and holds great promise since it is a noninvasive, highly accurate, well-controllable and locally effective treatment method [4][5][6].…”