Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy

Chen, Si; Lei, Qi; Qiu, Wen‐Xiu; Liu, Li‐Han; Zheng, Di‐Wei; Fan, Jin‐Xuan; Rong, Lei; Sun, Yunxia; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2016.11.056

Cited by 150 publications

(136 citation statements)

References 42 publications

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“…[8] However, under physiological temperatures,the decomposition of these initiators to induce cell death is limited, and an in situ heater is highly desirable to accelerate the generation of free radicals.G old-based nanomaterials such as Au nanorods, [9] Au nanocages, [10] and Au nanostars [11] are widely investigated photothermal conversion agents with good biocompatibility.I np articular, Au nanocages (AuNCs) are well-suited as the initiator carrier and heat source.T heir unique structural advantages with hollow interiors and porous walls are beneficial to achieve high drug loading capacity and controlled drug delivery. [8] However, under physiological temperatures,the decomposition of these initiators to induce cell death is limited, and an in situ heater is highly desirable to accelerate the generation of free radicals.G old-based nanomaterials such as Au nanorods, [9] Au nanocages, [10] and Au nanostars [11] are widely investigated photothermal conversion agents with good biocompatibility.I np articular, Au nanocages (AuNCs) are well-suited as the initiator carrier and heat source.T heir unique structural advantages with hollow interiors and porous walls are beneficial to achieve high drug loading capacity and controlled drug delivery.…”

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confidence: 99%

Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

2017

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Tumor hypoxia greatly suppresses the therapeutic efficacy of photodynamic therapy (PDT), mainly because the generation of toxic reactive oxygen species (ROS) in PDT is highly oxygen-dependent. In contrast to ROS, the generation of oxygen-irrelevant free radicals is oxygen-independent. A new therapeutic strategy based on the light-induced generation of free radicals for cancer therapy is reported. Initiator-loaded gold nanocages (AuNCs) as the free-radical generator were synthesized. Under near-infrared light (NIR) irradiation, the plasmonic heating effect of AuNCs can induce the decomposition of the initiator to generate alkyl radicals (R ), which can elevate oxidative-stress (OS) and cause DNA damages in cancer cells, and finally lead to apoptotic cell death under different oxygen tensions. As a proof of concept, this research opens up a new field to use various free radicals for cancer therapy.

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Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

2017

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“…Thermally decomposable azo initiators are well-known radical generators,w hich are not only used in free radical polymerization, but also applied in biological systems to induce oxidative-stress (OS). [8] However, under physiological temperatures,the decomposition of these initiators to induce cell death is limited, and an in situ heater is highly desirable to accelerate the generation of free radicals.G old-based nanomaterials such as Au nanorods, [9] Au nanocages, [10] and Au nanostars [11] are widely investigated photothermal conversion agents with good biocompatibility.I np articular, Au nanocages (AuNCs) are well-suited as the initiator carrier and heat source.T heir unique structural advantages with hollow interiors and porous walls are beneficial to achieve high drug loading capacity and controlled drug delivery. [12] Moreover, they also exhibit advantages of tunable surface plasmon resonance (SPR) band in near-infrared region, high photothermal conversion efficiency, and good photothermal stability.…”

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confidence: 99%

Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

2017

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Tumor hypoxia greatly suppresses the therapeutic efficacy of photodynamic therapy( PDT), mainly because the generation of toxic reactive oxygen species (ROS) in PDT is highly oxygen-dependent. In contrast to ROS, the generation of oxygen-irrelevant free radicals is oxygen-independent. An ew therapeutic strategy based on the light-induced generation of free radicals for cancer therapyi sr eported. Initiator-loaded gold nanocages (AuNCs) as the free-radical generator were synthesized.U nder near-infrared light (NIR) irradiation, the plasmonic heating effect of AuNCs can induce the decomposition of the initiator to generate alkylr adicals (RC), which can elevate oxidative-stress (OS) and cause DNAd amages in cancer cells,a nd finally lead to apoptotic cell death under different oxygen tensions.A saproof of concept, this research opens up an ew field to use various free radicals for cancer therapy.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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“…Besides, trimodel combined therapy by the integration of TPep, DOX, and PTT was developed as well. By subsequent TPep conjugation, DOX loading as well as targeting polymer (i.e., hyaluronic acid (HA)) coating, the as‐prepared AuNS‐based nanoplatform (AuNS‐pep/DOX@HA) could efficiently deliver DOX, mitochondria‐targeted TPep and AuNS “nanoheater” into cancer cells or even to their subcellular targets for synergistic tumor ablation, thus laying the technical foundation for organelle‐targeted trimodel therapy by integrating three different therapeutic agents into one single nanosystem (Figure c) . Furthermore, tumor‐suppressing genes (e.g., p53) could also be combined with TPep owing to their distinctive cell‐killing mechanisms .…”

Section: Therapeutic Strategies Toward Specific Subcellular Compartmentsmentioning

confidence: 99%

Section: Therapeutic Strategies Toward Specific Subcellular Compartmentsmentioning

confidence: 99%

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

2018

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Recently, diverse functional materials that take subcellular structures as therapeutic targets are playing increasingly important roles in cancer therapy. Here, particular emphasis is placed on four kinds of therapies, including chemotherapy, gene therapy, photodynamic therapy (PDT), and hyperthermal therapy, which are the most widely used approaches for killing cancer cells by the specific destruction of subcellular organelles. Moreover, some non-drug-loaded nanoformulations (i.e., metal nanoparticles and molecular self-assemblies) with a fatal effect on cells by influencing the subcellular functions without the use of any drug molecules are also included. According to the basic principles and unique performances of each treatment, appropriate strategies are developed to meet task-specific applications by integrating specific materials, ligands, as well as methods. In addition, the combination of two or more therapies based on multifunctional nanostructures, which either directly target specific subcellular organelles or release organelle-targeted therapeutics, is also introduced with the intent of superadditive therapeutic effects. Finally, the related challenges of critical re-evaluation of this emerging field are presented.

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Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy

Cited by 150 publications

References 42 publications

Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

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