2017
DOI: 10.1016/j.mad.2016.12.005
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Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity

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Cited by 85 publications
(60 citation statements)
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References 202 publications
(130 reference statements)
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“…In the human colorectal adenocarcinoma cell line, AMPK is involved in mitochondrial biogenesis via OPA1 . In aging and obesity, OPA1‐related mitochondrial activity and dynamics are also regulated by AMPK . Moreover, AMPK activation prevents drug‐induced hepatocyte injury by promoting OPA1‐related mitochondrial fusion .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the human colorectal adenocarcinoma cell line, AMPK is involved in mitochondrial biogenesis via OPA1 . In aging and obesity, OPA1‐related mitochondrial activity and dynamics are also regulated by AMPK . Moreover, AMPK activation prevents drug‐induced hepatocyte injury by promoting OPA1‐related mitochondrial fusion .…”
Section: Discussionmentioning
confidence: 99%
“…60 In aging and obesity, OPA1-related mitochondrial activity and dynamics are also regulated by AMPK. 61 Moreover, AMPK activation prevents drug-induced hepatocyte injury by promoting OPA1-related mitochondrial fusion. 62 AMPK is a classical antiapoptotic pathway, and ample evidence has reported the promotive role of melatonin on AMPK activation.…”
Section: Discussionmentioning
confidence: 99%
“…The inner mitochondrial membrane is extensively folded, producing invaginations called cristae, which control oxidative phosphorylation (OXPHOS), electron and metabolite transport, and cell death and survival (3). Consequently, mitochondrial network dysregulation is linked to several pathophysiological conditions, including cancer, diabetes, and neurodegenerative diseases (4)(5)(6)(7)(8).…”
mentioning
confidence: 99%
“…Conversely, mitochondrial dynamics is controlled by mitochondrion-shaping proteins that regulate fusion and fission events. Core components of the mitochondrial fusion/ fission machinery include mitofusin 1 (MFN1), mitofusin 2 (MFN2), and optic atrophy 1 (OPA1), which promote fusion, whereas fission is governed by dynamin-related protein 1 (DRP1) and by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins (MiD49 and MiD51), and fission 1 (FIS1) (1)(2)(3)(4)(5)(6)(7)(8).…”
mentioning
confidence: 99%
“…In vivo and vitro experiments have both illustrated that altered mitochondrial dynamics give rise to metabolic block and abnormal quantity of ROS, resulting in metabolic diseases(Liesa & Shirihai, 2013; Lopez-Lluch, 2017; Yoon et al, 2006). Mitochondrial dynamics disorders are common in metabolic diseases.…”
Section: Introductionmentioning
confidence: 99%