Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Zhang, Qing; Ren, Jun; Wang, Fangfang; Pan, Manman; Cui, Long; Li, Mingqian; Qu, Fan

doi:10.1016/j.freeradbiomed.2022.05.010

Cited by 56 publications

(41 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mild oxidative stress induces the expression of SIRTs probably as a compensatory mechanism, while severe or long-lasting oxidant conditions result in decreased SIRT levels due to the generation of dysfunctional modified SIRTs that are more prone to degradation by the proteasome [ 81 ]. In addition, SIRT3 deficiency in granulosa cells of PCOS patients may contribute to mitochondrial dysfunction, elevated oxidative stress, and defects in glucose metabolism, which potentially induce impaired oocytes in PCOS [ 82 ]. Therefore, the correlation between epigenetic factors and ROS generation can also manifest itself the other way around.…”

Section: Oxidative Stress and Inflammatory Signaling In Pcosmentioning

confidence: 99%

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Szukiewicz

Trojanowski

Kociszewska

et al. 2022

IJMS

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Despite its incidence, the syndrome is poorly understood and remains underdiagnosed, and female patients are diagnosed with a delay. The heterogenous nature of this complex disorder results from the combined occurrence of genetic, environmental, endocrine, and behavioral factors. Primary clinical manifestations of PCOS are derived from the excess of androgens (anovulation, polycystic ovary morphology, lack of or scanty, irregular menstrual periods, acne and hirsutism), whereas the secondary manifestations include multiple metabolic, cardiovascular, and psychological disorders. Dietary and lifestyle factors play important roles in the development and course of PCOS, which suggests strong epigenetic and environmental influences. Many studies have shown a strong association between PCOS and chronic, low-grade inflammation both in the ovarian tissue and throughout the body. In the vast majority of PCOS patients, elevated values of inflammatory markers or their gene markers have been reported. Development of the vicious cycle of the chronic inflammatory state in PCOS is additionally stimulated by hyperinsulinemia and obesity. Changes in DNA methylation, histone acetylation and noncoding RNA levels are presented in this review in the context of oxidative stress, reactive oxygen species, and inflammatory signaling in PCOS. Epigenetic modulation of androgenic activity in response to inflammatory signaling is also discussed.

show abstract

Section: Oxidative Stress and Inflammatory Signaling In Pcosmentioning

confidence: 99%

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Szukiewicz

Trojanowski

Kociszewska

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…A study found that the decreased expression of mir-181a could inhibit the apoptosis of GCs in vitro and in vivo by upregulating the expression of SIRT1 and the deacetylation of the pro-apoptotic factor FoxO1 (61,62). The expression of Sirtuin 3 (SIRT3) was significantly reduced in GCs of PCOS patients, while the knockdown of SIRT3 could change the acetylation state of NDUFS1, which may induce mitochondrial dysfunction, elevated oxidative stress, and glucose metabolism defects, leading to damage of oocytes in PCOS (63). Protein lysine acetylation is not only found on histones that affect chromatin structure and gene expression, but also on non-histones involved in a variety of cellular processes, thus providing an opportunity to explore the mechanism of acetylation regulation of PCOS as a drug target for the development of new therapies.…”

Section: Acetylationmentioning

confidence: 99%

Posttranslational modifications in pathogenesis of PCOS

et al. 2022

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a lifelong reproductive, metabolic, and psychiatric disorder that affects 5-18% of women, which is associated with a significantly increased lifetime risk of concomitant diseases, including type 2 diabetes, psychiatric disorders, and gynecological cancers. Posttranslational modifications (PTMs) play an important role in changes in protein function and are necessary to maintain cellular viability and biological processes, thus their maladjustment can lead to disease. Growing evidence suggests the association between PCOS and posttranslational modifications. This article mainly reviews the research status of phosphorylation, methylation, acetylation, and ubiquitination, as well as their roles and molecular mechanisms in the development of PCOS. In addition, we briefly summarize research and clinical trials of PCOS therapy to advance our understanding of agents that can be used to target phosphorylated, methylated, acetylated, and ubiquitinated PTM types. It provides not only ideas for future research on the mechanism of PCOS but also ideas for PCOS treatments with therapeutic potential.

show abstract

“…High levels of oxidative stress in the follicular fluid are associated with poor oocyte maturation and embryo quality [26]. Mitochondrial dysfunction that is characterized by high levels of accumulated free radicals is the key cause of oxidative stress and oxidative stress-induced cell aging [27]. Antioxidants such as Melatonin, Coenzyme Q, Vitamins A and E may be crucial for increasing the reproductive capacity by improving mitochondrial function.…”

Section: Antioxidantsmentioning

confidence: 99%

Adjuvant therapy in assisted fertilization procedures

Bila

Spremović-Radjenović

2022

Srp Arh Celok Lek

View full text Add to dashboard Cite

Introduction. Despite continuous advances in assisted reproductive technologies (ART), their outcomes are limited. Before introducing adjuvant therapy to improve the in vitro fertilization (IVF) outcome, it is important to identify appropriate groups of patients, and avoid equal approach for everyone. Objective The objective of this paper was to review the available literature on the most commonly used adjuvant therapy aiming to improve the outcome of IVF. The guidelines of the European Society for Human Reproduction and Embryology (ESHRE) and the American Society for Reproductive Medicine (ASRM) were used, and the available literature was analyzed by searching the Medline-PubMed and Cochrane databases using appropriate keywords for each entity. Discussion. A review of the literature found no consistent evidences for the standard use of metformin in patients with polycystic ovarian syndrome (PCOSy), nor for use of dehydroepiandrosterone (DHEA), testosterone (T) and growth hormone (GH) in patients with premature ovarian failure or those with poor response to stimulation. The standard usage of prednisone and aspirin in the general population of patients in ART is also not recommended. Recently, the significance of the oxidative stress has been emphasized, which is why the use of antioxidants in the form of supplementation (Melatonin, vitamins C, A, E, Coenzyme Q) might be important in improving reproductive outcomes. Conclusion. The modern approach to the problem of infertility has become strictly individual. The application of adjuvant therapy in order to improve the outcome of ART procedures requires an analytical and critical approach in each individual case.

show abstract

Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Cited by 56 publications

References 63 publications

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Posttranslational modifications in pathogenesis of PCOS

Adjuvant therapy in assisted fertilization procedures

Contact Info

Product

Resources

About