Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

Liao, Shishi; Luo, Jie; Kadier, Tulanisa; Ding, Ke; Chen, Rong; Meng, Qingtao

doi:10.3389/fphar.2022.854994

Cited by 26 publications

(18 citation statements)

References 194 publications

(209 reference statements)

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“…MtDNA activates the innate immune responses and mediates inflammation through the TLR-9, NLRP3 inflammasome, and cGAS-STING signaling pathways. 91 In addition, the regulation of mitochondria in innate immunity is affected by intermediate products of the metabolic pathway. Itaconate (ITA) is a Krebs cycle metabolite with anti-inflammatory activity.…”

Section: Treatment Of Sepsis By Regulating Mitochondrial Functionmentioning

confidence: 99%

Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation

Liu¹,

Liu²,

Zheng³

et al. 2023

JIR

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Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosuppression. This review summarizes metabolic reprogramming and its regulatory mechanism in sepsis-induced hyperinflammation and immunosuppression, highlights the significance and intricacies of immune cell metabolic reprogramming, and emphasizes the pivotal role of mitochondria in metabolic regulation and treatment of sepsis. This review provides an up-to-date overview of the relevant literature to inform future research directions in understanding the regulation of sepsis immunometabolism. Metabolic reprogramming has great promise as a new target for sepsis treatment in the future.

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Section: Treatment Of Sepsis By Regulating Mitochondrial Functionmentioning

confidence: 99%

Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation

Liu¹,

Liu²,

Zheng³

et al. 2023

JIR

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“…Mechanically, in the TLR9 signaling pathway, mtDNA binds to the TLR9 of neutrophils to stimulate neutrophils to release measuring matrix metalloproteinase (MMP)-8 and MMP-9 and produce TNF-α, IL-1, IL-6, and other proinflammatory factors. Furthermore, in the NLRP3 signaling pathway, mtDNA is released into the cytoplasm after mitochondrial injury, then induces the activation of the NLRP3 inflammasome, and contributes to the secretion of IL-1β and IL-18 ( Liao et al., 2022 ).…”

Section: Novel Role Of Metabolism-associated Molecular Patterns In Se...mentioning

confidence: 99%

The Novel Role of Metabolism-Associated Molecular Patterns in Sepsis

Zhu

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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Sepsis, a life-threatening organ dysfunction, is not caused by direct damage of pathogens and their toxins but by the host’s severe immune and metabolic dysfunction caused by the damage when the host confronts infection. Previous views focused on the damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), including metabolic proinflammatory factors in sepsis. Recently, new concepts have been proposed to group free fatty acids (FFAs), glucose, advanced glycation end products (AGEs), cholesterol, mitochondrial DNA (mtDNA), oxidized phospholipids (OxPLs), ceramides, and uric acid into metabolism-associated molecular patterns (MAMPs). The concept of MAMPs will bring new guidance to the research and potential treatments of sepsis. Nowadays, sepsis is regarded as closely related to metabolic disorders, and MAMPs play an important role in the pathogenesis and development of sepsis. According to this view, we have explained MAMPs and their possible roles in the pathogenesis of sepsis. Next, we have further explained the specific functions of different types of MAMPs in the metabolic process and their interactional relationship with sepsis. Finally, the therapeutic prospects of MAMPs in sepsis have been summarized.

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“…Intestinal I/R involves a complex mechanism. In the event of I/R, intestinal immune barrier dysfunction will lead to cytokine release, intestinal inflammatory injury and bacterial invasion and migration [ 6 ], resulting in serious body damage. Many studies have demonstrated successful application of BMSCs in reducing intestinal mucosal I/R damage in animal models [ 7 , 8 ], which proposing a new strategy for the management of intestinal I/R impairments.…”

Section: Introductionmentioning

confidence: 99%