Mitochondrial dynamics coordinate cell differentiation

Noguchi, Masafumi; Kasahara, Atsuko

doi:10.1016/j.bbrc.2017.06.094

Cited by 45 publications

(43 citation statements)

References 79 publications

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“…Mitochondrial fission and fusion proteins contain various (predicted) PTM sites, allowing their phosphorylation, Snitrosilation, sumoylation, ubiquitination, tyrosine sulfation, acetylation, and S-palmitoylation (5,70,279,425). Depending on the nature and location of the PTM, either mitochondrial fission or fusion is stimulated (51,103,289). These mechanisms are explained in more detail below (sections III.A.1-12).…”

Section: A Regulation By Post-translationlal Modifications Of Fissiomentioning

confidence: 99%

“…In addition, mitochondria constitute an integral part of the mechanisms that control cell functioning and survival. This is exemplified by their established physiological role in cell differentiation (289), immune cell function (40,252,261), cell death regulation (20,123), calcium homeostasis (77,109,110,434), and neurogenesis (175). In addition, mitochondrial dysfunction is associated with a multitude of pathophysiological conditions, including metabolic disorders (196), cancer (6,53), diabetes (336,436), and neurodegeneration (188).…”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial Morphofunction in Mammalian Cells

Bulthuis

Adjobo‐Hermans

Willems

et al. 2019

Antioxidants & Redox Signaling

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Significance: In addition to their classical role in cellular ATP production, mitochondria are of key relevance in various (patho)physiological mechanisms including second messenger signaling, neuro-transduction, immune responses and death induction. Recent Advances: Within cells, mitochondria are motile and display temporal changes in internal and external structure (''mitochondrial dynamics''). During the last decade, substantial empirical and in silico evidence was presented demonstrating that mitochondrial dynamics impacts on mitochondrial function and vice versa. Critical Issues: However, a comprehensive and quantitative understanding of the bidirectional links between mitochondrial external shape, internal structure and function (''morphofunction'') is still lacking. The latter particularly hampers our understanding of the functional properties and behavior of individual mitochondrial within single living cells. Future Directions: In this review we discuss the concept of mitochondrial morphofunction in mammalian cells, primarily using experimental evidence obtained within the last decade. The topic is introduced by briefly presenting the central role of mitochondria in cell physiology and the importance of the mitochondrial electron transport chain (ETC) therein. Next, we summarize in detail how mitochondrial (ultra)structure is controlled and discuss empirical evidence regarding the equivalence of mitochondrial (ultra)structure and function. Finally, we provide a brief summary of how mitochondrial morphofunction can be quantified at the level of single cells and mitochondria, how mitochondrial ultrastructure/volume impacts on mitochondrial bioreactions and intramitochondrial protein diffusion, and how mitochondrial morphofunction can be targeted by small molecules.

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Section: A Regulation By Post-translationlal Modifications Of Fissiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mitochondrial Morphofunction in Mammalian Cells

Bulthuis

Adjobo‐Hermans

Willems

et al. 2019

Antioxidants & Redox Signaling

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“…Moreover, organelle fission through DRP1 also contributes to additional intracellular dynamics processes, notably pexophagy and mitophagy, which provide quality control mechanisms to remove low-functioning organelles and their damaged proteins (Twig et al, 2008;Manivannan et al, 2013;Mao et al, 2013Mao et al, , 2014. Furthermore, Drp1/Dnm1 can exert an important impact on cell fate during development through its influence on cell cycle progression and in key signaling pathways (reviewed in Mitra, 2013;Lopez-Mejia and Fajas, 2015;Noguchi and Kasahara, 2018), and thereby regulate cell differentiation (e.g., Mitra et al, 2012). Therefore, it is possible that ascospore formation in P. anserina involves the multifaceted activity of these fission proteins.…”

Section: Discussionmentioning

confidence: 99%

Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the Fungus Podospora anserina

et al. 2020

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Mitochondria and peroxisomes are organelles whose activity is intimately associated and that play fundamental roles in development. In the model fungus Podospora anserina, peroxisomes and mitochondria are required for different stages of sexual development, and evidence indicates that their activity in this process is interrelated. Additionally, sexual development involves precise regulation of peroxisome assembly and dynamics. Peroxisomes and mitochondria share the proteins mediating their division. The dynamin-related protein Dnm1 (Drp1) along with its membrane receptors, like Fis1, drives this process. Here we demonstrate that peroxisome and mitochondrial fission in P. anserina depends on FIS1 and DNM1. We show that FIS1 and DNM1 elimination affects the dynamics of both organelles throughout sexual development in a developmental stage-dependent manner. Moreover, we discovered that the segregation of peroxisomes, but not mitochondria, is affected upon elimination of FIS1 or DNM1 during the division of somatic hyphae and at two central stages of sexual development-the differentiation of meiocytes (asci) and of meiotic-derived spores (ascospores). Furthermore, we found that FIS1 and DNM1 elimination results in delayed karyogamy and defective ascospore differentiation. Our findings reveal that sexual development relies on complex remodeling of peroxisomes and mitochondria, which is driven by their common fission machinery.

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“…Mitochondria are highly dynamic, and the balance of fission and fusion dictates their morphology. Multiple evidences revealed a strong link between mitochondrial metabolism and dynamics . Depolarization of the mitochondria triggers fission, inhibits fusion, and promotes mitophagy .…”

Section: Introductionmentioning

confidence: 99%

“…Multiple evidences revealed a strong link between mitochondrial metabolism and dynamics. [25][26][27] Depolarization of the mitochondria triggers fission, inhibits fusion, and promotes mitophagy. 28 Moreover, studies confirmed an imbalance of fission and fusion activities in cancer cells, with elevated fission activity and/or decreased fusion activity resulting in a fragmented mitochondrial morphology.…”

Section: Introductionmentioning

confidence: 99%

Effect of magnesium on reducing the UV‐induced oxidative damage in marrow mesenchymal stem cells

Chen

Xiong

Zhao

et al. 2019

J Biomedical Materials Res

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Oxidative stress could cause damage to lipids, proteins and DNA, which is induced by the imbalance between the production of reactive oxygen species (ROS) and the biological system ability to counteract or detoxify their harmful effects. The oxidative stress damage significantly contributes to a number of diseases. Magnesium (Mg) is endowed with a novel function of removing excess ROS by releasing H2 during the degradation. In this study, in order to explore the property of anti‐oxidative damage of Mg metal, rat bone marrow mesenchymal stem cells (MSCs) oxidative damaged by ultraviolet (UV) radiation was employed to co‐culture with Mg metal. The effect of Mg metal on the response of antioxidant enzymes and mitochondria in MSCs was studied. We found that Mg metal could reduce the cellular oxidative stress damage and elevate the activities of antioxidant enzymes to maintain redox homeostasis. In addition, Mg metal could reduce the risk of UV‐induced cell apoptosis by increasing the ratio of Bcl‐2/Bax, elevating the mitochondrial membrane potential and blocking the release of cytochrome c. This finding showed Mg metal might have the potential for treating diseases caused by oxidative stress damage. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1253–1263, 2019.

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Mitochondrial dynamics coordinate cell differentiation

Cited by 45 publications

References 79 publications

Mitochondrial Morphofunction in Mammalian Cells

Mitochondrial Morphofunction in Mammalian Cells

Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the Fungus Podospora anserina

Effect of magnesium on reducing the UV‐induced oxidative damage in marrow mesenchymal stem cells

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