Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain

Lam, Ho Yin Pekkle; Chen, Cheng Chi; Chen, Tina Tu Wen; Chang, Kai Chih; Wu, Wen Jui; Yang, Ting; Liang, Ting Ruei; Cheng, Po Ching; Peng, Shih-Yi

doi:10.1016/j.parint.2020.102231

Cited by 3 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrathin sections of the cerebral cortex fixed in 2.5% glutaraldehyde were prepared following published methods 38 . Briefly, samples were dehydrated in a graded series of ethanol, embedded in eponate 812, and cut into ultrathin sections.…”

Section: Methodsmentioning

confidence: 99%

Semen Ziziphi Spinosae attenuates blood–brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

et al. 2022

View full text Add to dashboard Cite

Semen Ziziphi Spinosae (SZS) has been extensively used in the daily diet as a functional food for neuroprotective health-benefit in China for many years. However, the neuroprotective mechanism of SZS associated with blood–brain barrier (BBB) integrity remains unexplored. The present study suggests SZS could protect against lipopolysaccharide (LPS)-induced BBB dysfunction. Proteomics indicate that 135 proteins in rat brain are significantly altered by SZS. These differentially expressed proteins are mainly clustered into cell–cell adhesion and adherens junctions, which are closely related with BBB integrity. SZS reversed LPS-induces BBB breakdown by activating the FAK-DOCK180-Rac1-WAVE2-Arp3 pathway. Molecular docking between signaling pathway proteins and identified SZS components in rat plasma reveals that 6”‘-feruloylspinosin, spinosin, and swertisin strongly binds to signaling proteins at multiple amino acid sites. These novel findings suggest a health benefit of SZS in prevention of cerebral diseases and contributes to the further application of SZS as a functional food.

show abstract

Section: Methodsmentioning

confidence: 99%

Semen Ziziphi Spinosae attenuates blood–brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

et al. 2022

View full text Add to dashboard Cite

show abstract

“…DRP1 is classified as a homologous protein of guanosine triphosphate (GTP) hydrolyzed enzyme (GTPase) power protein. It has an active role in endocytosis and is a key regulatory factor in mitochondrial fission, primarily located in cell pulp ( 20 , 45 , 46 ).…”

Section: The Physiological State Of Mitochondrial Dynamics and Mitophagymentioning

confidence: 99%

“…Mitochondrial fusion is divided into outer membrane fusion and endometrial fusion. It is regulated by a variety of proteins, including mitofusin (MFN) in the outer membrane of mitochondria and optic atrophy protein 1 (OPA1) ( 44 , 45 , 49 , 51 , 56 – 61 ). Among them, mitofusin 1 (MFN1) and mitofusin 2 (MFN2) regulate mitochondrial outer membrane fusion.…”

Section: The Physiological State Of Mitochondrial Dynamics and Mitophagymentioning

confidence: 99%

Advances in Cardiotoxicity Induced by Altered Mitochondrial Dynamics and Mitophagy

Yin

Shen

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Mitochondria are the most abundant organelles in cardiac cells, and are essential to maintain the normal cardiac function, which requires mitochondrial dynamics and mitophagy to ensure the stability of mitochondrial quantity and quality. When mitochondria are affected by continuous injury factors, the balance between mitochondrial dynamics and mitophagy is broken. Aging and damaged mitochondria cannot be completely removed in cardiac cells, resulting in energy supply disorder and accumulation of toxic substances in cardiac cells, resulting in cardiac damage and cardiotoxicity. This paper summarizes the specific underlying mechanisms by which various adverse factors interfere with mitochondrial dynamics and mitophagy to produce cardiotoxicity and emphasizes the crucial role of oxidative stress in mitophagy. This review aims to provide fresh ideas for the prevention and treatment of cardiotoxicity induced by altered mitochondrial dynamics and mitophagy.

show abstract

Defective glycolysis in the cerebrum and cerebellum correlates with the pathology and neurological declines in mice with Angiostrongylus cantonensis infection

Peng,

Lam,

Huang

2024

Parasitology International

View full text Add to dashboard Cite

Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain

Cited by 3 publications

References 48 publications

Semen Ziziphi Spinosae attenuates blood–brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

Semen Ziziphi Spinosae attenuates blood–brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

Advances in Cardiotoxicity Induced by Altered Mitochondrial Dynamics and Mitophagy

Defective glycolysis in the cerebrum and cerebellum correlates with the pathology and neurological declines in mice with Angiostrongylus cantonensis infection

Contact Info

Product

Resources

About