Mitochondrial Dysfunction in Traumatic Brain Injury: Management Strategies

Abstract

Today, traumatic brain injuries continue to be studied, increasingly investigating the pathophysiological mechanisms that contribute to the clinical presentation, severity, and possible sequelae, but despite this, the prognosis of these patients is sometimes poor. Mitochondrial dysfunction comprises a series of reactions that contribute to the inflammatory process in these patients that have an impact on the prognosis, since it is one of the pathophysiological mechanisms involved in secondary lesions after a traumatic brain injury; and therefore has opened a field of study in the search of possible biomolecular markers that allow us to establish a prognosis and prediction of mortality.

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

“…It is obvious that mitochondria are the major subcellular components essential for proper cellular functioning and cell survival [281]. Currently, there is a body of evidence implying that mitochondrial dysfunction plays a significant role in the pathophysiology of TBI [5,57,282]. Accordingly, mitochondria-targeted therapy may be of great value in suppressing brain tissue damage in brain-injured patients [88,283].…”