Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer

Shen, Liang; Zhan, Xianquan

doi:10.1155/2022/5634724

Cited by 19 publications

(21 citation statements)

References 184 publications

(194 reference statements)

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“…Mitochondrial dynamics are closely related to the activity of neuronal cells, but some studies have shown that phenotypic changes in cancer cells are also affected by mitochondrial dynamic defects ( Sehrawat et al, 2016 ; Shen and Zhan, 2022 ). The substances required for tumor metabolism include amino acids and are closely related to mitochondrial metabolism.…”

Section: Discussionmentioning

confidence: 99%

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Chen

Wei²,

Huang³

et al. 2023

Front. Mol. Biosci.

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Gastric cancer (GC) is a malignant cancer that reduces life expectancy worldwide. Although treatment strategies have improved, patients with GC still have poor prognoses. Hence, it is necessary to understand the molecular mechanisms of GC and to find new therapeutic targets. Mitochondrial dynamics and mitochondrial dysfunction are associated with cancer cell growth and progression. Numerous studies have reported that non-coding RNAs (ncRNAs) can participate in the occurrence and development of GC by regulating mitochondrial dynamics. Elucidating the crosstalk between ncRNAs and mitochondria would be helpful in preventing and treating GC. Herein, we review and summarize the functions of oncogenes and tumor suppressors in suppressing ncRNAs and regulating mitochondrial dynamics in GC tumor growth, proliferation, invasion and metastasis. This review provides new insights into the pathogenesis of and intervention for GC.

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Section: Discussionmentioning

confidence: 99%

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Chen

Wei²,

Huang³

et al. 2023

Front. Mol. Biosci.

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“…In addition, it has been reported that mitochondrial fusion increases ATP generation and fission contributes to mtDNA stress through mitochondrial dysfunction. 63 The imbalance of mitochondrial dynamics leads to mitochondrial DNA mutations and deletions, and these abnormalities have also been reported in endometriotic cells. 11 In fact, the mtDNA 16 189 variants and the combination of mtDNA 16 189 and 10 398 variants have been reported to be associated with endometriosis.…”

Section: Mitochondrial Dynamics In Endometriosismentioning

confidence: 99%

The role of mitochondrial dynamics in the pathophysiology of endometriosis

Kobayashi,

Matsubara,

Yoshimoto

et al. 2023

J of Obstet and Gynaecol

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AimEndometriosis is a chronic disease of reproductive age, associated with pelvic pain and infertility. Endometriotic cells adapt to changing environments such as oxidative stress and hypoxia in order to survive. However, the underlying mechanisms remain to be fully elucidated. In this review, we summarize our current understanding of the pathogenesis of endometriosis, focusing primarily on the molecular basis of energy metabolism, redox homeostasis, and mitochondrial function, and discuss perspectives on future research directions.MethodsPapers published up to March 31, 2023 in the PubMed and Google Scholar databases were included in this narrative literature review.ResultsMitochondria serve as a central hub sensing a multitude of physiological processes, including energy production and cellular redox homeostasis. Under hypoxia, endometriotic cells favor glycolysis and actively produce pyruvate, nicotinamide adenine dinucleotide phosphate (NADPH), and other metabolites for cell proliferation. Mitochondrial fission and fusion dynamics may regulate the phenotypic plasticity of cellular energy metabolism, that is, aerobic glycolysis or OXPHOS. Endometriotic cells have been reported to have reduced mitochondrial numbers, increased lamellar cristae, improved energy efficiency, and enhanced cell proliferation and survival. Increased mitochondrial fission and fusion turnover by hypoxic and normoxic conditions suggests an activation of mitochondrial quality control mechanisms. Recently, candidate molecules that influence mitochondrial dynamics have begun to be identified.ConclusionThis review suggests that unique energy metabolism and redox homeostasis driven by mitochondrial dynamics may be linked to the pathophysiology of endometriosis. However, further studies are needed to elucidate the regulatory mechanisms of mitochondrial dynamics in endometriosis.

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“…Changes in mitochondrial energy metabolism have recently been suggested as possible causes for chemoresistance and tumor recurrence in HGSOC (2,7,23,40,41). To further investigate the changes in mitochondrial function, we obtained nine surgically removed normal ovarian and ovarian tumor tissue biopsies from the Tissue Procurement Center at the Marshall University Edwards Comprehensive Cancer Center, Huntington, WV.…”

Section: Heterogeneity Of Mitochondrial Energy Metabolism In Ovarian ...mentioning

confidence: 99%

Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer

Koc

Sollars²,

Zgheib³

et al. 2023

Front. Oncol.

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IntroductionOvarian cancer is one of the leading causes of death for women with cancer worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian cancer (HGSOC) are fulfilled by a combination of aerobic glycolysis and oxidative phosphorylation (OXPHOS). Although reduced OXPHOS activity has emerged as one of the significant contributors to tumor aggressiveness and chemoresistance, up-regulation of mitochondrial antioxidant capacity is required for matrix detachment and colonization into the peritoneal cavity to form malignant ascites in HGSOC patients. However, limited information is available about the mitochondrial biogenesis regulating OXPHOS capacity and generation of mitochondrial reactive oxygen species (mtROS) in HGSOC.MethodsTo evaluate the modulation of OXPHOS in HGSOC tumor samples and ovarian cancer cell lines, we performed proteomic analyses of proteins involved in mitochondrial energy metabolism and biogenesis and formation of mtROS by immunoblotting and flow cytometry, respectively.Results and discussionWe determined that the increased steady-state expression levels of mitochondrial- and nuclear-encoded OXPHOS subunits were associated with increased mitochondrial biogenesis in HGSOC tumors and ovarian cancer cell lines. The more prominent increase in MT-COII expression was in agreement with significant increase in mitochondrial translation factors, TUFM and DARS2. On the other hand, the ovarian cancer cell lines with reduced OXPHOS subunit expression and mitochondrial translation generated the highest levels of mtROS and significantly reduced SOD2 expression. Evaluation of mitochondrial biogenesis suggested that therapies directed against mitochondrial targets, such as those involved in transcription and translation machineries, should be considered in addition to the conventional chemotherapies in HGSOC treatment.

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Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer

Cited by 19 publications

References 184 publications

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

The role of mitochondrial dynamics in the pathophysiology of endometriosis

Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer

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