Mitochondrial Evolution

Gray, Michael W.

doi:10.1101/cshperspect.a011403

Cited by 545 publications

(344 citation statements)

References 58 publications

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“…The retention of ribosomal RNA coding sequences, a universal trait of modern mitochondrial genomes (Gray, 2012), allowed mtDNA lineages to be traced to a single origin from an ancestral alphaproteobacterium of the order Rickettsiales (Ferla et al, 2013). Thus, mitochondria and Wolbachia not only share their lifestyles and mode of propagation but also their ancestry.…”

Section: Mitochondria and Wolbachia Originsmentioning

confidence: 99%

“…A recent and relatively well-supported hypothesis on the origin of mitochondria states that their alphaproteobacterium ancestor (protomitochondrion) fused to or was engulfed by a highly complex archaeobacterium (instead of a basal amitochondrial eukaryote as classically believed). Under this "symbiogenic" hypothesis, the evolutionary novelty of eukaryotic cells emerged after or as a consequence of the establishment of this symbiosis (Koonin, 2010;Gray, 2012). Interestingly, such a scenario provides a plausible selective factor for the evolution of eukaryotic cellular compartmentalization.…”

Section: Mitochondria and Wolbachia Originsmentioning

confidence: 99%

“…During eukaryotic evolution, such lateral gene transfer (LGT) was substantial, which partially accounts for the fact that nuclear genes now encode the vast majority of the mitochondrial proteome. In fact, the role of LGT goes beyond organelle function, and genes that formerly belonged to the protomitochondrion are now involved in other cellular processes (Gray, 2012).…”

Section: Genomic Reduction and Lateral Gene Transfermentioning

confidence: 99%

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Wolbachia Associations with Insects: Winning or Losing Against a Master Manipulator

2016

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Wolbachia are intracellular, maternally inherited bacteria with an impressive history of adaptation to intracellular lifestyles. Instead of adapting to a single host lineage, Wolbachia evolved ways to jump across host species and establish relatively stable associations maintained through vertical transmission. Wolbachia are capable of manipulating the reproduction of infected hosts in a remarkable way. Traditionally, such reproductive manipulations have been regarded as the general mechanism by which Wolbachia spread through host populations. Recent evidence suggests that Wolbachia-host interactions are more complex than previously thought and may be driven by the onset and resolution of conflicts of interest. Here, we discuss how reproductive manipulation phenotypes may be transient. As the host adapts to infection, manipulation phenotypes attenuate and the continuity of the symbioses may rely on the physiological advantages Wolbachia may confer to their host. For facultative symbionts, such benefits are likely to be dependent on the environment. Here, we also review evidence that supports the view of environment-dependent facultative mutualism as a stable evolutionary outcome of Wolbachia infections beside extinction and obligate symbioses. Finally, our current understanding of the biology of mitochondria and Wolbachia unravels remarkable parallels in the way they interact with the nuclear genome. Great insights into both the Wolbachia and mitochondrial research fields can be revealed if such fields are considered to be overlapping, rather than independent from each other.

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Section: Mitochondria and Wolbachia Originsmentioning

confidence: 99%

Section: Mitochondria and Wolbachia Originsmentioning

confidence: 99%

Section: Genomic Reduction and Lateral Gene Transfermentioning

confidence: 99%

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Wolbachia Associations with Insects: Winning or Losing Against a Master Manipulator

2016

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“…While the endosymbiont theory states that mitochondria and plastids derive from α-proteobacteria and cyanobacteria respectively, metabolic integration of these endosymbionts has evidently implied the massive participation of genes whose ancestry cannot be traced back to these two sole clades [1,2]. In particular, plastid endosymbiosis is known to correlate with a phylogenomic imprint from intracellular chlamydia pathogens specific and selective to all lineages derived from this unique event [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 98%

Toward an understanding of the function of Chlamydiales in plastid endosymbiosis

Ball

Colleoni

Kadouche

et al. 2015

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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Plastid endosymbiosis defines a process through which a fully evolved cyanobacterial ancestor has transmitted to a eukaryotic phagotroph the hundreds of genes required to perform oxygenic photosynthesis, together with the membrane structures, and cellular compartment associated with this process. In this review, we will summarize the evidence pointing to an active role of Chlamydiales in metabolic integration of free living cyanobacteria, within the cytosol of the last common plant ancestor.

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“…In a yeast strain in which the RNA splicing-related functions of Mss116p are dispensable, overexpression of RPO41 or MSS116 increases cell survival from colonies that were exposed to low temperature, suggesting a role for Mss116p in enhancing the efficiency of mitochondrial transcription under stress conditions. E nergy production in eukaryotic cells depends upon the function of mitochondria, double-membrane organelles that are thought to have evolved from an ancient bacterial endosymbiont (1,2). While most proteins that are essential for mitochondrial (mt) function are encoded by nuclear genes and imported into the organelle, a subset of critical proteins, mostly components of the oxidative phosphorylation complex and mitochondrion-specific ribosomal and tRNAs, are encoded in the mt genome (3,4).…”

mentioning

confidence: 99%

Yeast DEAD Box Protein Mss116p Is a Transcription Elongation Factor That Modulates the Activity of Mitochondrial RNA Polymerase

Markov

Wojtas

Tessitore

et al. 2014

Molecular and Cellular Biology

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DEAD box proteins have been widely implicated in regulation of gene expression. Here, we show that the yeast Saccharomyces cerevisiae DEAD box protein Mss116p, previously known as a mitochondrial splicing factor, also acts as a transcription factor that modulates the activity of the single-subunit mitochondrial RNA polymerase encoded by RPO41. Binding of Mss116p stabilizes paused mitochondrial RNA polymerase elongation complexes in vitro and favors the posttranslocated state of the enzyme, resulting in a lower concentration of nucleotide substrate required to escape the pause; this mechanism of action is similar to that of elongation factors that enhance the processivity of multisubunit RNA polymerases. In a yeast strain in which the RNA splicing-related functions of Mss116p are dispensable, overexpression of RPO41 or MSS116 increases cell survival from colonies that were exposed to low temperature, suggesting a role for Mss116p in enhancing the efficiency of mitochondrial transcription under stress conditions. E nergy production in eukaryotic cells depends upon the function of mitochondria, double-membrane organelles that are thought to have evolved from an ancient bacterial endosymbiont (1, 2). While most proteins that are essential for mitochondrial (mt) function are encoded by nuclear genes and imported into the organelle, a subset of critical proteins, mostly components of the oxidative phosphorylation complex and mitochondrion-specific ribosomal and tRNAs, are encoded in the mt genome (3, 4). Therefore, expression of nuclear and mt genes must be coordinately regulated (5, 6). As a consequence, mitochondria have developed a highly active RNA surveillance/degradation system to ensure the integrity of mt transcripts and to regulate the availability of mt mRNA by balancing the rates of RNA synthesis and degradation (7,8,9).Little is known about how transcription is controlled in mitochondria and what proteins participate in adjusting the rates of mt RNA synthesis and degradation. In the yeast Saccharomyces cerevisiae, mt transcription is carried out by an RNA polymerase (RNAP) consisting of a single-subunit catalytic core (Rpo41p) that is related to T7 RNA polymerase (T7 RNAP) and an additional transcription factor (Mtf1p) for initiation (10,11,12). RNA degradation in turn depends upon a two-subunit mt degradosome that includes Suv3p, a processive helicase that unwinds double-stranded RNA (dsRNA), and Dss1p, a 3= to 5= exonuclease (13,14). Importantly, deletion of SUV3 is suppressed by mutations in RPO41 and MTF1, suggesting that alterations in these components of the transcription system help to restore the balance between RNA synthesis and degradation (8). The SUV3 deletion is also suppressed by overexpression of Mss116p, an mt DEAD box protein that is involved in RNA splicing, processing, and possibly translation (15,16). While this effect might be attributed to compensation for Suv3p deficiency by a protein that has RNA unwinding activity, we have recently found that Mss116p is associated with the mt trans...

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Mitochondrial Evolution

Cited by 545 publications

References 58 publications

Wolbachia Associations with Insects: Winning or Losing Against a Master Manipulator

Wolbachia Associations with Insects: Winning or Losing Against a Master Manipulator

Toward an understanding of the function of Chlamydiales in plastid endosymbiosis

Yeast DEAD Box Protein Mss116p Is a Transcription Elongation Factor That Modulates the Activity of Mitochondrial RNA Polymerase

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