Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors

Wang, Dalin; Jian-guo, Tian; Yan, Zeyu; Yuan, Qing; Wu, Dan; Liu, Xiaoli; Yang, Shirong; Guo, Shanshan; Wang, Jianxun; Yang, Yongxiu; Xing, Jinliang; An, Jing; Huang, Qichao

doi:10.1016/j.ymthe.2022.01.032

Cited by 16 publications

(7 citation statements)

References 68 publications

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“…HB is the most common malignant liver tumor in children, but most cases cannot be operated on in one stage because of its large volume and proximity to the surrounding blood vessels ( 18 – 20 ). Neoadjuvant chemotherapy can significantly reduce the tumor volume so that most tumors can be completely removed and a good prognosis can be obtained ( 21 – 23 ).…”

Section: Discussionmentioning

confidence: 99%

Application of 3D Simulation Software in Chemotherapy and Hepatoblastoma Surgery in Children

et al. 2022

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PurposeThis study aims to explore the clinical value of a computer-assisted surgery system (Hisense CAS) in hepatoblastoma (HB) surgery in children after neoadjuvant chemotherapy.Patients and MethodsThe clinical medical records of children with HB treated after neoadjuvant chemotherapy at the Affiliated Hospital of Qingdao University from January 2016 to January 2019 were analyzed retrospectively.ResultsA total of 21 children were enrolled in this study, including 13 boys and 8 girls. All cases successfully underwent three-dimensional (3D) reconstruction of the liver and tumor using Hisense CAS, simulated hepatectomy, and hepatectomy according to the preoperative operation plan. There were twelve cases of right hemihepatectomy, four cases of right trefoil hepatectomy, one case of left lobe hepatectomy, and three cases of middle lobe hepatectomy, and one case of V and VI segment hepatectomy. All children recovered well after the operation. The follow-up ranged from 5 months to 3 years. One child died of systemic metastasis 8 months after the operation. One child received one course of chemotherapy after the operation. Due to the serious reaction to the chemotherapy, the family refused further treatment and follow-up. The remaining 19 children had no complications or recurrence.ConclusionHisense CAS can clearly and intuitively display the position and shape of the HB before and after chemotherapy and its relationship with the intrahepatic pipeline system and accurately evaluate the changes in tumor volume and the distance between important blood vessels, which is conducive to the operator selecting the best operation opportunity, timely formulating the best operation plan and implementing individualized and accurate liver tumor resection.

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Section: Discussionmentioning

confidence: 99%

Application of 3D Simulation Software in Chemotherapy and Hepatoblastoma Surgery in Children

et al. 2022

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“…5d), indicating that ATB1021 per se does not trigger mitophagic flux in macrophages. The induction of mitophagy is further monitored by qPCR analysis of specific mitochondrial genes, such as MT-ND1 (mitochondrially encoded NADH dehydrogenase 1) and MT-16S rRNA, which can represent mitochondrial DNA (mtDNA) copy number per cell 39,40 . As shown in Fig.…”

Section: A P62 Ligand Activates Mitophagy In Macrophagesmentioning

confidence: 99%

Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

et al. 2023

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The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-terminal signal peptide, is connected to p62/SQSTM1-mediated autophagy. However, the impact of the molecular link between the N-degron and autophagy pathways is largely unknown in the context of systemic inflammation. Here, we show that chemical mimetics of the N-degron Nt-Arg pathway (p62 ligands) decreased mortality in sepsis and inhibited pathological inflammation by activating mitophagy and immunometabolic remodeling. The p62 ligands alleviated systemic inflammation in a mouse model of lipopolysaccharide (LPS)-induced septic shock and in the cecal ligation and puncture model of sepsis. In macrophages, the p62 ligand attenuated the production of proinflammatory cytokines and chemokines in response to various innate immune stimuli. Mechanistically, the p62 ligand augmented LPS-induced mitophagy and inhibited the production of mitochondrial reactive oxygen species in macrophages. The p62 ligand-mediated anti-inflammatory, antioxidative, and mitophagy-activating effects depended on p62. In parallel, the p62 ligand significantly downregulated the LPS-induced upregulation of aerobic glycolysis and lactate production. Together, our findings demonstrate that p62 ligands play a critical role in the regulation of inflammatory responses by orchestrating mitophagy and immunometabolic remodeling.

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“…Hydrodynamic delivery has been used to develop animal models not only of hepatitis B virus infection but also of a wide variety of other diseases, including hepatitis C virus infection [75,76,[87][88][89][90][91], hepatocellular carcinoma [92][93][94][95], hepatoblastoma [96][97][98], cholangiocellular carcinoma [99][100][101][102], liver fibrosis [103,104], nonalcoholic fatty liver disease [103,105,106], hemophilia B [107], von Willebrand disease [108,109], thrombotic thrombocytopenic purpura [110,111], malaria [79,80], enterovirus 71 infection [112], pseudoxanthoma elasticum [113], psoriasis [114], intracerebral aneurysm [115], the human immune system [116,117], and metastasis of melanoma, breast cancer, and renal cell carcinoma to the lungs, liver, and kidney [118,119].…”

Section: Targeted Diseasesmentioning

confidence: 99%

“…Hepatitis B virus (HBV) [72,73,84,85] Hepatocellular carcinoma [51,[92][93][94][95] Hemophilia A and B [70,107,[127][128][129][130] Liver fibrosis [82,103,104,[149][150][151] Hepatitis C virus [71,75,76,[87][88][89][90][91] Hepatoblastoma [96][97][98] Pseudoxanthoma elasticum [113] Nonalcoholic fatty liver diseases [103,105,106,152,153] Hepatitis D virus [74] Cholangiocellular carcinoma [99][100][101][102] von Willebrand disease [108,109,131,132] Alcoholic liver injury [154,155] Influenza virus…”

Section: Cancer Hereditary Livermentioning

confidence: 99%

Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances

et al. 2023

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The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.

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Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors

Cited by 16 publications

References 68 publications

Application of 3D Simulation Software in Chemotherapy and Hepatoblastoma Surgery in Children

Application of 3D Simulation Software in Chemotherapy and Hepatoblastoma Surgery in Children

Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances

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