Mitochondrial-nuclear interactions and lifespan control in fungi

Osiewacz, Heinz D.; Kimpel, Erik

doi:10.1016/s0531-5565(99)00063-7

Cited by 44 publications

(22 citation statements)

References 32 publications

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“…Impairments in mitochondrial activity lead to degenerative processes, a variety of diseases and aging, which is an extremely complex process involving a plethora of cross-talking cellular mechanisms. [1][2][3][4][5][6] Several pathways are dedicated to ensure the uncompromised ability of mitochondria to cope with changing cellular demands. [7][8][9][10][11][12] One pathway that recently gained special interest is the regulation and execution of mitochondrial fusion and fission.…”

Section: Introductionmentioning

confidence: 99%

Unopposed mitochondrial fission leads to severe lifespan shortening

Scheckhuber¹,

Wanger²,

Mignat³

et al. 2011

Cell Cycle

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Section: Introductionmentioning

confidence: 99%

Unopposed mitochondrial fission leads to severe lifespan shortening

Scheckhuber¹,

Wanger²,

Mignat³

et al. 2011

Cell Cycle

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“…mean lifespan of wildtype strain(s) on corn meal medium: 25 days) and is accessible to genetic and molecular manipulation. Over the years of intensive investigation, a huge body of data has been accumulated indicating that different pathways like DNA stability/instability, respiration, generation and scavenging of reactive oxygen species (ROS), regulation of copper homeostasis, mitochondrial dynamics, and apoptotic pathways are part of the molecular network governing aging and lifespan in this system (for review, see Osiewacz & Kimpel, 1999;Osiewacz, 2002a;Hamann et al ., 2008). In addition, first data about age-related changes of the proteome emerged recently resulting in the identification of novel, or poorly characterized components involved in the molecular control of aging (Hunzinger et al ., 2006;Groebe et al ., 2007).…”

Section: Introductionmentioning

confidence: 99%

Over‐expression of an S‐adenosylmethionine‐dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions

Kunstmann

Osiewacz

2008

Aging Cell

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SummaryPaMTH1, a putative methyltransferase previously described to increase in abundance in total protein extracts during aging of Podospora anserina is demonstrated to accumulate in the mitochondrial cell fraction of senescent cultures. The protein is localized in the mitochondrial matrix and displays a methyltransferase activity utilizing flavonoids as substrates. Constitutive over-expression of PaMth1 in P. anserina results in a reduced carbonylation of proteins and an extended lifespan without impairing vital functions suggesting a protecting role of PaMTH1 against oxidative stress.

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“…During the last several decades, a huge amount of data has accumulated that suggest that oxidative stress is a major determinant of degenerative processes including various diseases and aging (for review, see Harman 1981;Sohal and Orr 1994;Martin et al 1996;Wallace and Melov 1998;Osiewacz and Kimpel 1999;Wallace 1999). Recently, the characterization of the long-lived mutant grisea of the ascomycete Podospora anserina has suggested that copper-mediated oxidative stress has a signi®cant eect on the lifespan of this fungal aging model.…”

Section: Introductionmentioning

confidence: 99%

Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina

et al. 2001

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The lifespan of the ascomycete Podospora anserina was previously demonstrated to be significantly increased in a copper-uptake mutant, suggesting that copper is a potential stressor involved in degenerative processes. In order to determine whether changes in copper stress occur in the cells during normal aging of cultures, we cloned and characterized a gene coding for a component of the molecular machinery involved in the control of copper homeostasis. This gene, PaMt1, is a single-copy gene that encodes a metallothionein of 26 amino acids. The coding sequence of PaMt1 is interrupted by a single intron. The deduced amino acid sequence shows a high degree of sequence identity to metallothioneins of the filamentous ascomycete Neurospora crassa and the basidiomycete Agaricus bisporus, and to the N-terminal portion of mammalian metallothioneins. Levels of PaMt1 transcript increase in response to elevated amounts of copper in the growth medium and during aging of wild-type cultures. In contrast, in the long-lived mutant grisea, transcript levels first increase but then decrease again. The ability of wild-type cultures to respond to exogenous copper stress via the induction of PaMt1 transcription is not affected as they grow older.

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Mitochondrial-nuclear interactions and lifespan control in fungi

Cited by 44 publications

References 32 publications

Unopposed mitochondrial fission leads to severe lifespan shortening

Unopposed mitochondrial fission leads to severe lifespan shortening

Over‐expression of an S‐adenosylmethionine‐dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions

Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina

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