Mitochondrial regulation of cell death: a phylogenetically conserved control

Galluzzi, Lorenzo; Kepp, Oliver; Kroemer, Guido

doi:10.15698/mic2016.03.483

Cited by 89 publications

(69 citation statements)

References 100 publications

(177 reference statements)

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“…Their dysfunctions can lead to serious consequences. For instance, mitochondrial alterations can go as far as to activate apoptosis [48], peroxisomal dysfunction affect the mitochondria, subsequently leading to oxidative stress and cell death [49,50], alterations of the lysosome may have consequences on the induction of autophagy and apoptosis [51], endoplasmic reticulum damages can lead to reticulum stress which can trigger different forms of cell death in extreme cases [52], and Golgi apparatus dysfunctions can disturb post-translational modifications and vesicular transport [53]. The incidence of the cytotoxicity of nanoparticles is often addressed in generalized terms such as induction of cell death, oxidative stress stimulation, inflammation activation and genotoxicity.…”

Section: Influence Of Nanoparticles On the Biogenesis And Activity Ofmentioning

confidence: 99%

Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles

Maurizi¹,

Papa²,

Boudon³

et al. 2018

Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications

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The lack of toxicological data on nanomaterials makes it difficult to assess the risk related to their exposure, and as a result further investigation is required. This chapter presents the synthesis of controlled oxide nanoparticles followed by the evaluation of their safety profile or toxicity (iron, titanium and zinc oxides). The controlled surface chemistry, dispersion in several media, morphology and surface charge of these nanoparticles are presented (transmission electron microscopy, dynamic light scattering, zeta potential, X-ray photoelectron spectroscopy). Classical cytotoxic and cellular uptake studies on different cancer cell lines from liver, prostate, heart, brain and spinal cord are discussed. The incidence of nanoparticles on biogenesis and activity of cell organelles is also highlighted, as well as their biodistribution in animal models. The acute toxicity on zebrafish embryo model is also presented. Finally, the stress is put on the influence and the necessity of controlling the protein corona, a layer of plasma proteins physically adsorbed at the surface of such nanoparticles as a result of their presence in the bloodstream (or relevant biological fluids).

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Section: Influence Of Nanoparticles On the Biogenesis And Activity Ofmentioning

confidence: 99%

Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles

Maurizi¹,

Papa²,

Boudon³

et al. 2018

Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications

View full text Add to dashboard Cite

show abstract

“…DHE is staining dye that is commonly used for superoxide mediated ROS detection in mitochondria. Lysosomal destabilization measurement using AO dye defines decline in lysosomal integrity in Cu‐treated cells in compare with control …”

Section: Discussionmentioning

confidence: 99%

“…Mitochondrial mediated intrinsic apoptosis pathway regulated by Bcl‐2 family proteins through the proapoptotic and antiapoptotic protein Bax and Bcl‐2, respectively . Several research studies have been supported that ROS can augment the mitochondrial membrane permeabilization . The Bax/Bcl‐2 ratio is responsible for particular activity of mitochondria …”

Section: Introductionmentioning

confidence: 99%

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Biochemical regulation and structural analysis of copper‐transporting ATPase in a human hepatoma cell line for Wilson disease

Agnihotry

Dhusia

Srivastav

et al. 2019

J of Cellular Biochemistry

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Hepatic copper levels differ among patients with Wilson disease (WD) and normal individuals depending on the dietary intake, copper bioavailability, and genetic factors. Copper chloride (CuCl2) caused dose‐dependent reduction in cell viability of human teratocarcinoma (HepG2) cell line, measured using the 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay. Cells were exposed to different concentrations of CuCl2 in log doses and maximum cell viability reduction was recorded at 15 µg/mL. Toxic dose of CuCl2 is potent inducer of reactive oxygen species (ROS). Apoptosis as a pattern of cell death was confirmed through sub‐G1 fraction and morphological changes such as mitochondrial depolarization, endoplasmic reticulum and lysosomal destabilization, phosphatidylserine translocation, and DNA damage. Our transcriptional and translational results strongly support apoptotic cell death. Using the available data present in dbSNP and bioinformatics tools, three nonsynonymous single nucleotide polymorphisms (nsSNPs) were identified as deleterious, reducing the stability of protein ATP7B. Structural analysis of native and mutant ATP7B proteins was investigated using molecular dynamics simulation (MDS) approach. Mutation in ATP7B gene might disturb the structural conformation and catalytic function of the ATP7B protein may be inducing WD. Hence, excess dietary intake of copper chloride must be avoided for safety of health to prevent from WD.

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“…While apoptosis is the best characterized and easiest to cell death program to analyze, it is not the only one. Other programs include: autophagy, necroptosis, pyroptosis, parthanatos, and autosis [reviewed in 57,58]. Dying muscles tend to employ non-apoptotic programs, such as the autophagic death of the ISMs in moths.…”

Section: Commentarymentioning

confidence: 99%

Skeletal Muscles Do not Undergo Apoptosis During Either Atrophy or Programmed Cell Death

Schwartz¹

2017

J Cell Signal

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Mitochondrial regulation of cell death: a phylogenetically conserved control

Cited by 89 publications

References 100 publications

Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles

Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles

Biochemical regulation and structural analysis of copper‐transporting ATPase in a human hepatoma cell line for Wilson disease

Skeletal Muscles Do not Undergo Apoptosis During Either Atrophy or Programmed Cell Death

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