Mitochondrial responsibility in ageing process: innocent, suspect or guilty

López-Lluch, Guillermo; Santos-Ocaña, Carlos; Sánchez-Alcázar, José A.; Fernández-Ayala, Daniel J. M.; Asencio-Salcedo, Claudio; Rodríguez-Aguilera, Juan Carlos; Navas, Plácido

doi:10.1007/s10522-015-9585-9

Cited by 62 publications

(40 citation statements)

References 223 publications

(237 reference statements)

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“…Therefore, we assume that XS cells, which are unable to store trehalose, might be defective in the adaptation to stress conditions, which explains their poor vitality. Trehalose is formed while cells are undergoing the shift from fermentative to respiratory metabolism (Futcher 2006), and it was shown that the trehalose pathway regulates mitochondrial respiratory chain content (Noubhani et al 2009, López-Lluch et al 2015). Since XS cells have very low respiration capacity, it points to defects in trehalose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

et al. 2015

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Cells of the budding yeast Saccharomyces cerevisiae undergo a process akin to differentiation during prolonged culture without medium replenishment. Various methods have been used to separate and determine the potential role and fate of the different cell species. We have stratified chronologically-aged yeast cultures into cells of different sizes, using centrifugal elutriation, and characterized these subpopulations physiologically. We distinguish two extreme cell types, very small (XS) and very large (L) cells. L cells display higher viability based on two separate criteria. They respire much more actively, but produce lower levels of reactive oxygen species (ROS). L cells are capable of dividing, albeit slowly, giving rise to XS cells which do not divide. L cells are more resistant to osmotic stress and they have higher trehalose content, a storage carbohydrate often connected to stress resistance. Depletion of trehalose by deletion of TPS2 does not affect the vital characteristics of L cells, but it improves some of these characteristics in XS cells. Therefore, we propose that the response of L and XS cells to the trehalose produced in the former differs in a way that lowers the vitality of the latter. We compare our XS- and L-fraction cell characteristics with those of cells isolated from stationary cultures by others based on density. This comparison suggests that the cells have some similarities but also differences that may prove useful in addressing whether it is the segregation or the response to trehalose that may play the predominant role in cell division from stationary culture.

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Section: Discussionmentioning

confidence: 99%

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

et al. 2015

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“…Some identified exogenous triggers include smoking (Behnia et al, 2016), air pollution (Fougere et al, 2015), persistent infections (Derhovanessian et al, 2011; Oppermann et al, 2012) and overweight or obesity (Giugliano et al, 2006). Several endogenous factors also play a relevant role, including: overproduction of reactive oxygen species (ROS) (Zhang et al, 2016) and advanced glycation end-products (AGEs) (Yamagishi and Matsui, 2016), mitochondrial dysfunction (Lopez-Lluch et al, 2015), renin-angiotensin system (RAS) deregulation (Duprez, 2006), hormonal changes (Epel and Lithgow, 2014; Gubbels Bupp, 2015), visceral adiposity (Palmer and Kirkland, 2016), changes in the gut microbiota (Biagi et al, 2010) and accumulation of cell debris due to a defective autophagy (Franceschi et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis

Custodero

Mankowski

Lee

et al. 2018

Ageing Research Reviews

129

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Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to examine the association of pre-selected interventions on two established biomarkers of inflammation, interleukin-6 (IL-6), and C-reactive protein (CRP) in middle-age and older adults with chronic LGI. We reviewed the literature on potential anti-inflammatory compounds, selecting them based on safety, tolerability, acceptability, innovation, affordability, and evidence from randomized controlled trials. Six compounds met all five inclusion criteria for our systematic review and meta-analysis: angiotensin II receptor blockers (ARBs), metformin, omega-3, probiotics, resveratrol and vitamin D. We searched in MEDLINE, PubMed and EMBASE database until January 2017. A total of 49 articles fulfilled the selection criteria. Effect size of each study and pooled effect size for each compound were measured by the standardized mean difference. I2 was computed to measure heterogeneity of effects across studies. The following compounds showed a significant small to large effect in reducing IL-6 levels: probiotics (−0.68 pg/ml), ARBs (−0.37 pg/ml) and omega-3 (−0.19 pg/ml). For CRP, a significant small to medium effect was observed with probiotics (−0.43 mg/L), ARBs (−0.2 mg/L), omega-3 (−0.17 mg/L) and metformin (−0.16 mg/L). Resveratrol and vitamin D were not associated with any significant reductions in either biomarker. These results suggest that nutritional and pharmaceutical compounds can significantly reduce established biomarkers of systemic inflammation in middle-age and older adults. The findings should be interpreted with caution, however, due to the evidence of heterogeneity across the studies.

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“…Oxidative stress and mitochondrial dysfunction are well known to increase during aging [12–14] including brain aging [15, 16] and are considered a major cause for cellular senescence [17–19]. During aging, neurons are exposed to high oxidative stress and accumulate dysfunctional mitochondria, damage to DNA, proteins and lipids and changes in energy homeostasis [16, 20].…”

Section: Introductionmentioning

confidence: 99%

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Miwa

Czapiewski

Wan

et al. 2016

Aging

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Mitochondrial responsibility in ageing process: innocent, suspect or guilty

Cited by 62 publications

References 223 publications

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

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