Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion

Jung, Chan-Hun; Kim, Eun Mi; Song, Jie‐Young; Park, Jong Kuk; Um, Hong‐Duck

doi:10.1038/s12276-019-0207-5

Cited by 23 publications

(22 citation statements)

References 34 publications

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“…In a previous study, a reduction in ROS generation in X-ray-treated cancer cells did not increase cell death (Wang and Zhang 2019). Moreover, γ -ray irradiation can induce cancer cell invasion by increasing ROS generation and decreasing SOD activity (Jung et al 2019). These observations indicate that the context-dependent functions of ROS in cell survival and death might be associated with the different species and levels of intracellular ROS (Kuwabara et al 2008).…”

Section: Discussionmentioning

confidence: 80%

ROS mediated radiotherapy-induced protective autophagy in thyroid cancer

et al. 2020

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Section: Discussionmentioning

confidence: 80%

ROS mediated radiotherapy-induced protective autophagy in thyroid cancer

et al. 2020

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“…Cell culture and treatments. Sources and authentication of HCT116 colon cancer cells, their p53-or p21-knockout variants, H460 and A549 lung cancer cells have been described previously (17,18). Cells were regularly screened for mycoplasma contamination using MycoAlert Mycoplasma Detection Kits (Lonza, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells

et al. 2021

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Our previous study revealed that the tumor suppressor/transcription factor p53 directly binds to its transcriptional target, p21, and that the p53/p21 complex binds to zinc finger protein SNAI2 (Slug), a tumor promoter/transcription factor; thereby promoting the degradation of Slug by Mdm2, an E3 ligase. The present study demonstrated that Slug reduced the cellular expression levels of p53 and p21 in HCT116 colon cancer by decreasing their protein stability. In parallel, Slug increased the mRNA and protein expression levels of Mdm2 in these cells. Moreover, knockdown of Mdm2 using specific small interfering RNAs abolished the ability of Slug to induce the degradation of p53 and p21. Considering the well-known function of Mdm2 in facilitating p53 and p21 degradation, these data suggested that Slug promoted p53 and p21 degradation by inducing Mdm2 expression. Moreover, Slug increased ubiquitination levels of p53 in HCT116 cells. This is consistent with the fact that Mdm2 induces p53 degradation by ubiquitinating p53, and further confirmed that Mdm2 acted downstream of Slug. Comparative studies using HCT116 cells and their p53-or p21-knockout variants have revealed that Slug requires p21 to induce p53 degradation. This result is consistent with our previous study, which revealed that Mdm2 acts more efficiently on p53 in the p53/p21 complex compared with on p53 alone. By contrast, Slug did not require p53 to induce p21 degradation, suggesting that p53 was dispensable in Mdm2-mediated p21 degradation. Notably, the ability of Slug to increase/decrease Mdm2/p53 and p21 levels, respectively, was not confined to HCT116 cells alone, but was also confirmed in A549 and H460 lung cancer cells. Collectively, the results of the present study suggested that Slug could counter p53 and p21. The balance between these two opposing groups (Slug vs. p53/p21) may depend on environmental stresses and the internal physiology of cells.

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“…12 Moreover, it is reported that increased SULF2 from sublethal doses of IR regulates IR-induced cancer cell invasion via mitochondrial superoxide dismutase 2 (SOD2). 13 These results suggest that IR promotes cancer cell invasion by activating different signaling pathway mediators, such as Bcl-X L , NF-κB, and SOD2.…”

mentioning

confidence: 88%

Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells

Lee

Han

Kang³

et al. 2020

Natural Product Communications

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Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 μM) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.

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Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion

Cited by 23 publications

References 34 publications

ROS mediated radiotherapy-induced protective autophagy in thyroid cancer

ROS mediated radiotherapy-induced protective autophagy in thyroid cancer

Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells

Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells

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