2020
DOI: 10.3325/cmj.2020.61.126
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Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

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Cited by 31 publications
(26 citation statements)
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“…One of the key considerations is the relationship between mitophagy and UPR mt [ 69 , 70 ]. As discussed above, UPR mt appears to be activated prior to mitophagy induction [ 71 ]. As endogenous UPR mt cannot completely repair mitochondrial damage, mitophagy activation is an inevitable consequence under stress conditions, regardless of UPR mt activation.…”
Section: Discussionmentioning
confidence: 99%
“…One of the key considerations is the relationship between mitophagy and UPR mt [ 69 , 70 ]. As discussed above, UPR mt appears to be activated prior to mitophagy induction [ 71 ]. As endogenous UPR mt cannot completely repair mitochondrial damage, mitophagy activation is an inevitable consequence under stress conditions, regardless of UPR mt activation.…”
Section: Discussionmentioning
confidence: 99%
“…UPRmt is of great benefit to the preservation of ATP production, reduction of mtROS accumulation, and inhibition of mitochondria-mediated cell death, and showed a protective effect in chronic and acute cardiac injury ( 77 ). Activating transcription factor associated with stress-1 (ATFS-1), an UPRmt-inducing transcription factor, was showed to preserve ATP production by promoting the assembly and function of oxidative phosphorylation components during mitochondrial stress ( 78 ).…”
Section: Dysregulation Of Mitochondrial Proteostasis In Heart Failurementioning
confidence: 99%
“…Mitochondria and endoplasmic reticulum (ER) in cardiomyocytes are overrepresented organelles to co-ordinate the increased metabolic demands and maintain active calcium stores for smooth flow. Endoplasmic reticulum and mitochondria quality control circuits are also integral to cardiac function, and deregulation of these pathways are strongly implicated in cardiac diseases including heart failure [57][58][59][60][61][62][63]. ECM remodeling is emerging to coincide with metabolic rewiring in cardiomyocytes and matrixguided control of mitochondrial function in cardiomyocytes is seen as a potential therapeutic target in cardiac fibrosis, repair, regeneration and tissue engineering [64].…”
Section: Abortive Cellular Homeostasis Rebalancing In Cardiac Fibrosimentioning
confidence: 99%