Mitogenic Effects of Neurotrophins on a Periodontal Ligament Cell Line

Tsuboi, Y; Nakanishi, Tohru; Takano‐Yamamoto, Teruko; Miyamoto, Manabu; Yamashiro, Takashi; Takigawa, Masaharu

doi:10.1177/00220345010800030701

Cited by 14 publications

(12 citation statements)

References 28 publications

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“…Although both BMP-1 and BMP-4 have been extensively studied and there is evidence to suggest that they have a role in hard tissue regeneration, 51,52 the relevance of brainderived neurotrophic factor (BDNF) in a mouse PDL cell line was described in a recent publication. 53 This growth factor belongs to a family of neutrotrophins and may be involved in neural tissue regeneration.…”

Section: Comparison Of Rt-pcr and Microarray Data (Mean Relative Ratimentioning

confidence: 99%

Gene Expression Profiles of Periodontal Ligament Cells Treated With Enamel Matrix Proteins In Vitro: Analysis Using cDNA Arrays

Parkar

Tonetti

2004

Journal of Periodontology

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Section: Comparison Of Rt-pcr and Microarray Data (Mean Relative Ratimentioning

confidence: 99%

Gene Expression Profiles of Periodontal Ligament Cells Treated With Enamel Matrix Proteins In Vitro: Analysis Using cDNA Arrays

Parkar

Tonetti

2004

Journal of Periodontology

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“…Concerning periodontal tissue regeneration, BDNF reportedly increased the synthesis of osteopontin, BMP-2, and collagen in human periodontal ligament (PDL) cells [10], strongly suggesting the existence of the Trk signaling pathway, which the receptor selectively binds to the BDNF [11]. It was further confirmed that a specific signaling pathway, TrkB-c-Raf-ERK1/2-Elk-1 was essential for the BDNF to induce mRNA expression of bone/cementum-related proteins [12] and also for the regulation of cementoblast survival [13].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects

et al. 2014

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This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.

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“…Mechanisms that could explain higher PDL regeneration potential with the use of BDNF have been previously speculated to be related to the increased synthesis of osteopontin, BMP‐2, and collagen in human periodontal ligament (PDL) cells, suggesting the existence of the Trk signaling pathway selectively binding to the BDNF …”

Section: Discussionmentioning

confidence: 99%

Regeneration of the cementum and periodontal ligament using local BDNF delivery in class II furcation defects

et al. 2017

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Periodontal furcation defects are usually addressed by the placement of a physical barrier which may limit the regenerative potential of periodontal wounds. This study morphometrically quantified the regenerative effect of brain-derived neurotrophic factor (BDNF) in furcation defects in a non-human primate model. Grade II furcation defects (with and without induced inflammation prior to surgery) were created on the first and second molars of eight non-human primates. Defects were treated with open flap debridement and subsequently filled with either: Group A; BDNF (500 µg mL ) in high-molecular weight-hyaluronic acid (HMW-HA), Group B; BDNF (50 µg mL ) in HMW-HA, Group C; HMW-HA acid only, Group D; unfilled defect, or Group E; BDNF (500 µg mL ) in saline. Periodontal wound healing was observed every 2 weeks by computed-tomography. At 11 weeks all animals were sacrificed and maxillary and mandibular block biopsies were referred for nondecalcified histology. Linear measurements of new cementum (cellular and acellular) and periodontal ligament (PDL) formation were performed. Computerized-tomography reconstruction and software quantification demonstrated successful bone fill for all groups. However, histometric assessment demonstrated significantly higher level of total periodontal regeneration for the 500 µg mL BDNF HMW-HA relative to all other groups. No significant differences in cementogenesis were observed among groups. Significantly higher acellular cementum formation was observed for sites where inflammation was not induced prior to surgical procedures. While all groups experienced similar bone fill and cementogenesis, the 500 µg mL BDNF HMW-HA appeared to most effectively repair PDL (minimum increase of ∼22% relative to all groups; over 200% relative to unfilled defects). © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1611-1617, 2018.

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Mitogenic Effects of Neurotrophins on a Periodontal Ligament Cell Line

Cited by 14 publications

References 28 publications

Gene Expression Profiles of Periodontal Ligament Cells Treated With Enamel Matrix Proteins In Vitro: Analysis Using cDNA Arrays

Gene Expression Profiles of Periodontal Ligament Cells Treated With Enamel Matrix Proteins In Vitro: Analysis Using cDNA Arrays

The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects

Regeneration of the cementum and periodontal ligament using local BDNF delivery in class II furcation defects

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