Mitos y evidencias en el empleo de la toxina botulínica: neurofarmacología y distonías

García‐Ruiz, Pedro J.; Sanz-Cartagena, P; Martínez‐Castrillo, Juan Carlos; Ares-Pensado, Begoña; Avilés-Olmos, Icíar; Blázquez-Estrada, Marta; Fanjul-Arbós, Samira; García‐Caldentey, Juan; Gazulla, José; Gutiérrez-García, José-Joaquín; Huete-Antón, B; Lucas-Rodenas, C; Luquín, M.R.; Martínez‐Torres, Irene; Medialdea-Natera, P.; Mendoza-Rodriguez, Amelia; P, Mir-Rivera; Posada, Ignacio J.; Ruíz‐Martínez, Javier; Sánchez-Alonso, Pilar; Galan, J M Trejo-Gabriel Y; Vela, Lydia; Peña-Segura, J L

doi:10.33588/rn.6605.2017110

Cited by 3 publications

(4 citation statements)

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“…Siguiendo con esta hipótesis, y teniendo en cuenta trabajos previos en los que la TB ha sido empleada con éxito para relajar los músculos escalenos y así conseguir un aumento de espacio relativo en el llamado desfiladero torácico, nos planteamos una terapia similar (10-13). Consideramos que, al relajar los músculos escalenos anterior y medio gracias a la quimiodenervación con toxina botulínica, era muy plausible que el efecto restrictivo de la musculatura sobre la tumoración en crecimiento cediera y, con ello, se redujera la clínica (14-16), sin olvidar su posible papel en la transmisión del dolor, como abogan ya muchos autores (17,18).…”

Section: Discussionunclassified

Schwannoma de plexo braquial y toxina botulínica: a propósito de un caso

Romera

Beltrán

Puerto

et al. 2021

Rev. Soc. Esp. Dolor.

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Section: Discussionunclassified

Schwannoma de plexo braquial y toxina botulínica: a propósito de un caso

Romera

Beltrán

Puerto

et al. 2021

Rev. Soc. Esp. Dolor.

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“…It has been reported that HC/A can bind to and activate fibroblast growth factor receptor 3 (FGFR3), which is a tyrosine kinase receptor, in neuroblastoma cells (24). Recently, it was reported that by using non-toxic full-length BoNT/A(0) mutant, a catalytically inactive, BoNT/A(0) enters cortical neurons via a pathway dependent on FGFR3 receptor (25). Further study showed that BoNT/A(0) enters neurons through both dynamin-dependent and dynamin-independent endocytosis (25).…”

Section: Overview Of Botulinum Neurotoxinsmentioning

confidence: 99%

“…Recently, it was reported that by using non-toxic full-length BoNT/A(0) mutant, a catalytically inactive, BoNT/A(0) enters cortical neurons via a pathway dependent on FGFR3 receptor (25). Further study showed that BoNT/A(0) enters neurons through both dynamin-dependent and dynamin-independent endocytosis (25).…”

Section: Overview Of Botulinum Neurotoxinsmentioning

confidence: 99%

“…Therefore, BoNTs therapy may also be beneficial for hyper-hidrotic disorders, urologic or gastrointestinal disorders (21). BoNT/A therapy had been applied for the management of many neurological disorders, such as dystonia and spasticity (25). Recently, a meta-analysis study including a total of 42 clinical trials reassessed the efficacy of BoNTs for movement disorders treatment, such as blepharospasm, hemifacial spasm, and laryngeal dystonia (27,28).…”

Section: Clinical Application Of Bonts In Neurologymentioning

confidence: 99%

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Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective

Liu

Luo

2021

Front. Psychiatry

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Depression is one of the most common mental disorders, which causes global burden. Antidepressants and psychotherapies are the mainstay of treatment for depression, which have limited efficacy. Thus, alternative approaches for preventing and treating depression are urgently required. Recent clinical trials and preclinical researches have clarified that peripheral facial injection of botulinum neurotoxin type A (BoNT/A) is a rapid, effective and relative safe therapy for improving some symptoms of depression. Despite its safety and efficacy, the underlying therapeutic mechanisms of BoNT/A for depression remains largely unclear. In the present review, we updated and summarized the clinical and preclinical evidence supporting BoNT/A therapy for the treatment of depression. We further discussed the potential mechanisms underlying therapeutic effects of BoNT/A on depression. Notably, we recently identified that the anti-depressant effects of BoNT/A associated with up-regulation of 5-HT levels and brain-derived neurotrophic factor (BDNF) expression in the hippocampus in a preclinical mouse model. In summary, these studies suggest that BoNT/A therapy is a potential effective and safe intervention for the management of depression. However, fundamental questions remain regarding the future prospects of BoNT/A therapy, including safety, efficacy, dose-response relationships, identification of potential predictors of response, and the precise mechanisms underlying BoNT/A therapy.

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Medical Applications of Botulinum Toxin: Spasticity

Núñez¹,

Castro²,

Núñez³

2022

Botulinum Toxin - Recent Topics and Applications

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Botulinum toxin is the most powerful toxin ever known. Its huge potential has been used in the last decades to treat some pathologies that attend with acetylcholine’s metabolic disturbances. Botulinum toxin effects are not indefinite in time, so it must be applied several times (usually twice a year), thanks to the changes produced by this toxin the rehabilitation of infantile spasticity are easier (the greatest results are seen on abductor muscles, calves, etc.) and on ocular muscles to treat squint. It is also used in some muscle alterations, pathologies of the autonomic nervous system, painful syndromes. The life quality of children with cerebral palsy is improving thanks to this toxin.

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Mitos y evidencias en el empleo de la toxina botulínica: neurofarmacología y distonías

Cited by 3 publications

References 0 publications

Schwannoma de plexo braquial y toxina botulínica: a propósito de un caso

Schwannoma de plexo braquial y toxina botulínica: a propósito de un caso

Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective

Medical Applications of Botulinum Toxin: Spasticity

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