Mitotane (o, DDD) resistance in a dog with pituitary‐dependent hyperadrenocorticism and phaeochromocytoma

Bennett, Peter; Espinosa, Norman

doi:10.1111/j.1751-0813.1998.tb14536.x

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…A sex predisposition for concurrent endocrine neoplasias in dogs was not apparent, which was in agreement with other reports 22–31 34 . Three cats reported in the literature with MEN1‐like syndrome were castrated males 32 33 .…”

Section: Discussionsupporting

confidence: 91%

“…4 9 21 In dogs and cats, the literature describing concurrent endocrine neoplasias is limited to single case reports or small case series. [22][23][24][25][26][27][28][29][30][31][32][33][34] MEN1-like syndrome characterised by the simultaneous occurrence of parathyroid adenoma and anterior pituitary adenoma was described in three dogs, 23 28 and MEN2-like syndrome with medullary thyroid carcinoma associated with pheochromocytoma and bilateral parathyroid hyperplasia was reported in one dog. 22 There have been three cases of MEN1-like syndrome in cats.…”

Section: Introductionmentioning

confidence: 99%

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Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004–2014)

et al. 2018

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Multiple endocrine neoplasia (MEN) is a well-known syndrome in human medicine, whereas only a few cases of concurrent endocrine neoplasias have been reported in dogs and cats. The aim of this study was to evaluate the prevalence of concurrent endocrine neoplasias in dogs and cats at our clinic, identify possible breed and sex predispositions and investigate similarities with MEN syndromes in humans. Postmortem reports of 951 dogs and 1155 cats that died or were euthanased at the Clinic for Small Animal Internal Medicine, University of Zurich, between 2004 and 2014 were reviewed, and animals with at least two concurrent endocrine neoplasias and/or hyperplasias were included. Twenty dogs and 15 cats met the inclusion criteria. In dogs, the adrenal glands were most commonly affected. Multiple tumours affecting the adrenal glands and the association of these tumours with pituitary adenomas were the most common tumour combinations. Only one dog had a combination resembling human MEN type 1 syndrome (pituitary adenoma and insulinoma). In cats, the thyroid glands were most commonly affected and there were no similarities to human MEN syndromes. The prevalence of concurrent endocrine neoplasia was 2.1 per cent in dogs and 1.3 per cent in cats and MEN-like syndromes are very rare in these species.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004–2014)

et al. 2018

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“…17 Rare reports of MEN exist in dogs; however, no genetic mutations have been associated with these cases. [18][19][20] Previous reports of dogs with concurrent hyperadrenocorticism and pheochromocytoma exist 21,22 , suggesting that MEN syndrome also occurs in dogs. In the dog of this study, an osteosarcoma of the right distal radius was diagnosed 21 months prior to the presentation with clinical signs of MEN, and this was confirmed on necropsy.…”

Section: Discussionmentioning

confidence: 99%

Paraganglioma, pituitary adenoma, and osteosarcoma in a dog

Robat

Houseright

Murphey³

et al. 2016

Veterinary Clinical Pathol

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An 11-year-old neutered male Alaskan Malamute mixed-breed dog was presented with a complaint of polyuria/polydipsia (PU/PD), weight loss, tachypnea, regurgitation, and a previous history of nontreated osteosarcoma of the right distal radius, diagnosed 21 months prior. On physical examination, an abdominal mass was palpated. The abdominal mass was aspirated and cytologically diagnosed as a neuroendocrine tumor, suspected to be a pheochromocytoma. Laboratory examination revealed a mild anemia and thrombocytopenia, markedly elevated ATP and ALP activities, and moderate hypercalcemia. A low-dose dexamethasone suppression test and endogenous adrenocorticotropic hormone (ACTH) concentration were compatible with pituitary hyperadrenocorticism. On urinalysis, proteinuria was noted as well as a high urine metanephrine/creatinine ratio, consistent with a diagnosis of pheochromocytoma. The dog was treated with supportive care and euthanized 6 months later due to decreasing quality of life. On necropsy, an extra-adrenal pheochromocytoma (paraganglioma) was diagnosed in the caudal abdomen, and a pituitary adenoma and an osteosarcoma of the right distal radius were confirmed.

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“…Reported cases of PCC with a possible hereditary component reduce to subtypes MEN 2A (Peterson et al, 1982) and MEN 2 (Wright et al, 1995) already mentioned in the MTC discussion. Other possible associations found in dogs are PCC and pituitary tumor (Von Dehn et al, 1995;Bennett and Norman, 1998) and PCC, adrenal cortical tumor and pituitary tumor (Thuróczy et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

Arias¹,

Castillo²,

Trigo³

et al. 2016

Open Vet J.

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Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Two adrenal neoplasms were identified incidentally by ultrasonography, and tumor in the left thyroid lobe was identified by palpation. Primary hyperparathyroidism was diagnosed by biochemical testing. Histopathology report was consistent with diagnosis of bilateral pheochromocytoma and parathyroid adenoma. Immunohistochemical staining was positive for calcitonin and synaptophysin, and negative for thyroglobulin, which confirmed medullary thyroid carcinoma. This case in a dog is presenting neoplastic characteristics similar to human MEN 2A and emphasizing the importance of using immunohistochemistry for confirmation.

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Mitotane (o, DDD) resistance in a dog with pituitary‐dependent hyperadrenocorticism and phaeochromocytoma

Cited by 11 publications

References 6 publications

Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004–2014)

Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004–2014)

Paraganglioma, pituitary adenoma, and osteosarcoma in a dog

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

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