Mitoxantrone-loaded zeolite beta nanoparticles: Preparation, physico-chemical characterization and biological evaluation

Controlled release of 5-fluorouracil from microporous zeolites

“…2 The dimensions of these pores, channels and cages are such that drug molecules can be accommodated inside them. [3][4][5][6][7] Moreover, the drug molecules are likely to diffuse out of the channel systems slowly, thus controlling their release rate. In a previous study we investigated the effect of different loading procedures on the release profile of the active compound.…”

Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios

“…Due to the well-defined pore structure and pore topology, zeolites are widely used for adsorption, catalysis and separations [10]. The use of zeolites in drug delivery [7,8,[11][12][13][14][15][16], adsorption of pharmaceuticals [17] and imaging [18][19][20][21][22][23] has been explored in the literature. Specifically, the loading and release of drugs, such as sulfonamide antibiotics [11,24], ibuprofen [14], doxorubicin [13], and mitoxantrone [16] in zeolites have been investigated.…”

Progress in zeolite synthesis promotes advanced applications

“…Controlled drug delivery requires the optimal release of the drug in efficient amounts while minimizing the side effects that can occur depending on the dosage forms. The nanosized zeolites possess both the micropores and textural mesopores that are potentially large enough to accommodate a wide-range of different drug molecules, such as sulfonamide antibiotics, ibuprofen, doxorubicin, mitoxantrone, aspirin and 5-Fluorouracil (5-FU) [54][55][56][57][58][59]. Compared to mesoporous materials, the zeolites have shown better loading of drugs.…”

“…Results showed that zeolites alone reveal no toxicity to cancer cells, while, importantly, anticancer drug-zeolite led to an inhibition of cell viability up to 585-fold when compared to the non-encapsulated drug. Moreover, mitoxantrone can also be excited at a wavelength of 600-660 nm and emits light at 675-685 nm, which gives the possibility to visualize the hybrid nanoparticles in biological media [57].…”