Controlled release of 5-fluorouracil from microporous zeolites

Spanakis, Marios; Bouropoulos, Nikolaos; Theodoropoulos, Dimitrios; Sygellou, Lamprini; Ewart, Sinead; Moschovi, Anastasia Maria; Siokou, A.; Niopas, Ioannis; Kachrimanis, Kyriakos; Nikolakis, Vladimiros; Cox, Paul A.; Vizirianakis, Ioannis S.; Fatouros, Dimitrios G.

doi:10.1016/j.nano.2013.06.016

Cited by 82 publications

(71 citation statements)

References 19 publications

(19 reference statements)

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“…Moreover, 5‐FU has high toxic side effects in the body and could increase the risk of toxic injury when a certain amount of is 5‐FU accumulated . Although the incidence of side effects can be reduced by drug‐delivery systems, an unsatisfactory 5‐FU loading and controlled release efficiency have been reported . Therefore, the development of a suitable drug carrier to control the release of 5‐FU is imperative.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive hollow magnetic microspheres with hyperthermia and controlled release properties

Chen

Zhang

et al. 2015

J of Applied Polymer Sci

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Thermoresponsive hollow magnetic microspheres consisting of a hollow magnetic core, a carbon shell, and a smart polymer layer are presented in this article. A carbon nanomaterial was used as a steric stabilizer for Fe 3 O 4 nanoparticles and a supporter for polymer. The thermoresponsive monomer, N-isopropyl acrylamide, was grafted on the carbon-encapsulate hollows by surface radical polymerization. The experimental results indicate that the composites had a phase-transition temperature around 438C and a saturation magnetization of 56.9 emu/g; this showed apparent thermosensitivity and magnetism. The performances in hyperthermia evaluated by an inductive magnetic field showed that the hybrid microspheres had a specific absorption rate of 240 W/g. The model drug, 5-fluorouracil, was loaded in and released from the microspheres with different release rates at 35 and 508C. This demonstrated that the as-synthesized microspheres had a thermotriggered release ability and would be a good drug carrier in the biomedical field.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive hollow magnetic microspheres with hyperthermia and controlled release properties

Chen

Zhang

et al. 2015

J of Applied Polymer Sci

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“…In the Z4A sample, the wavenumbers 422, 555 and 1004 cm −1 are related to the vibrations of Al─O or Si─O bending, double ring and XO 4 asymmetric stretch (X = Al or Si), respectively. 20 According to the literature, 18,45 the large bandwidth between 3000 and 3600 cm −1 corresponds to Si─OH (or Al─OH) groups and hydrogen bonds located on the external surface and the internal channels. It is evident that the absorbance of the characteristic band of the NA11-Z4A sample is twice than that of Z4A.…”

Section: Mechanism Of the Dispersibility Enhancement Of Na11-z4a Inmentioning

confidence: 99%

“…Zeolites with highly ordered pores and cavity systems have been used as supports of catalysts . It may be used as the dispersion supports of nucleating agents.…”

Section: Introductionmentioning

confidence: 99%

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Effect of nucleating agent supported on zeolite via the impregnation on the crystallization ability of isotactic polypropylene and its mechanism

Tong

Meng

et al. 2019

Polymers for Advanced Techs

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Addition of an α‐nucleating agent is the simple and effective method to increase nucleation efficiency of isotactic polypropylene (iPP). However, severe agglomeration and poor dispersibility of sodium 2,2′‐methylene‐bis(4,6‐di‐tertbutylphenyl) phosphate (NA11) decrease the nucleation efficiency in the iPP, and much more nucleating agent is needed to maintain the nucleating property. As a result, it becomes the key how to decrease the size of NA11 and increase the nucleating property. In this paper, zeolite 4A (Z4A) was firstly supported by NA11 through solution impregnation, and NA11 was dispersed by Z4A depending on the dispersion of zeolite as carrier for the second component. Then, the dispersed NA11 system (NA11‐Z4A) exhibited a superior nucleation behavior during the crystallization of the iPP matrix when it was used with iPP together. The isothermal and nonisothermal crystallization kinetics indicated that the NA11‐Z4A/iPP system had the best crystallization effect. Polarized optical microscopy (POM) and scanning electron microscopy (SEM) analyses showed that the size of NA11 decreased obviously when it was adsorbed on the surface of Z4A, which leads a better dispersibility of the nucleating agent and thus an accelerated nucleation process in the iPP matrix. In the end, the mechanism for the excellent dispersibility of NA11‐Z4A, which was based on hydrogen bonding between NA11 and Z4A, was confirmed by Fourier‐transform infrared spectroscopy (FTIR). Based on the research work, the solution impregnation strategy can potentially be applied to other systems to inhibit the agglomeration and improve the dispersibility of additives in iPP.

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“…Fairly few are, however, the references claiming BEA zeolite as a drug delivery system [9,21e24]. The cytocompatibility of BEA zeolitic particles has been previously evaluated and results demonstrated that the aluminosilicate material did not affect the viability of human epithelial colorectal adenocarcinoma cell lines (Caco-2) [9].…”

Section: Introductionmentioning

confidence: 99%

Dissolution enhancement of the poorly soluble drug nifedipine by co-spray drying with microporous zeolite beta

Karavasili

Kokove

Κοντοπούλου

et al. 2016

Journal of Drug Delivery Science and Technology

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Controlled release of 5-fluorouracil from microporous zeolites

Cited by 82 publications

References 19 publications

Thermoresponsive hollow magnetic microspheres with hyperthermia and controlled release properties

Thermoresponsive hollow magnetic microspheres with hyperthermia and controlled release properties

Effect of nucleating agent supported on zeolite via the impregnation on the crystallization ability of isotactic polypropylene and its mechanism

Dissolution enhancement of the poorly soluble drug nifedipine by co-spray drying with microporous zeolite beta

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