Mitral Valve Prolapse

Levine, Robert A.; Jerosch‐Herold, Michael; Hajjar, Roger J.

doi:10.1016/j.jacc.2018.07.006

Cited by 13 publications

(3 citation statements)

References 28 publications

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“…Mitral valve prolapse also known as fl oppy mitral valve syndrome, systolic click-murmur syndrome is a valvular heart disease disorder and is characterized by typical fi bromyxomatous changes in the mitral leafl et tissue with superior displacement of one or both leafl ets into the left atrium. Various symptoms like chest pain, dyspnea, syncope, palpitations and clinical fi ndings like low blood pressure and electrocardiographic repolarization abnormalities have been associated with MVP (10). It may be sporadic or familial.…”

Section: Introductionmentioning

confidence: 99%

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

Abacıoğlu¹

2021

BLL

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BACKGROUND: Mitral valve prolapse (MVP) is a common disorder, affl icting 2 % to 3 % of the general population. Despite the general belief of a benign disorder, there is an increasing awareness of an association between mitral valve prolapse and sudden cardiac death from arrhythmia and also atherosclerosis. Monocyte to high density lipoprotein ratio (MHR) is a new tool for predicting infl ammation, which plays a major role in atherosclerosis. OBJECTIVE: To evaluate the relationship between MHR and the presence of MVP. METHODS: The study population consisted of 82 patients with MVP and the control group of 78 normal individuals. Transthoracic echocardiograpy was performed for all of the study population and peripheral venous blood samples were drawn for measuring MHR and other haemotological parameters. RESULTS: The patients with MVP were more likely to have higher MHR values (15.82 ± 6.01 in MVP patients and 13.30 ± 6.43 in controls; p=0.011). Monocyte counts and MHR of the MVP group were signifi cantly higher than the control group and MHR values were directly proportional with the regurgitation area. CONCLUSION: The MHR is strongly associated with MVP and regurgitation area and might be a prognostic factor for patients with MVP

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Section: Introductionmentioning

confidence: 99%

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

Abacıoğlu¹

2021

BLL

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“…CMR is a useful tool to detect myocardial fibrosis, which is associated with a higher incidence of arrhythmias in patients with MR and is an independent predictor of increased incidence of adverse clinical outcomes in patients undergoing MVR (25). The type and extent of myocardial fibrosis correlated with the remodeling of the left ventricle in the clinical and postoperative context of MV disease (26,27). MA abnormalities have been correlated with increased presence of fibrosis, arrhythmias, and ventricular dysfunction in studies with CMR (28), demonstrating the importance of preservation of mitral annular mobility in the treatment of MR.…”

Section: ' Discussionmentioning

confidence: 99%

Cardiac Magnetic Resonance Analysis of Mitral Annular Dynamics after Mitral Valve Repair

Abdouni

Brandão

Rochitte

et al. 2020

Clinics

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The aim of this study was to analyze mitral annulus (MA) dynamics using cardiac magnetic resonance (CMR) in patients with degenerative mitral insufficiency who underwent mitral valve repair (MVR). METHODS: Mitral valve imaging was performed by CMR in twenty-nine patients with degenerative mitral insufficiency who underwent MVR between July 2014 and August 2016, with quadrangular resection of the posterior leaflet without ring annuloplasty. They were prospectively followed up from the preoperative period up to 2 years postoperatively. RESULTS: We observed a significant reduction in all measurements of the MA after surgery. The mean systolic circumference of the MA was reduced from 13.28 ± 1.95 cm to 11.50 ± 1.59 cm, and the diastolic circumference was reduced from 12.51 ± 2.01 cm to 10.66 ± 2.09 cm in the immediate postoperative period, measures that remained stable 2 years after MVR (po0.001). The mean maximum area of the MA was significantly reduced from 14.34±4.03 to 10.45±3.17 cm 2 when comparing the immediate postoperative period and the 2 year follow-up (po0.001). The same occurred with the mean minimum area of the MA, which was reduced from 12.53 ± 3.68 cm 2 to 9.23 ± 2.84 cm 2 in the same period, and this reduction was greater in the antero-posterior diameter than in the mid-lateral diameter. The mobility of the MA was preserved after surgery, ranging between 19.6% and 25.7% at 2-year follow-up. CONCLUSION: We observed a significant reduction in the MA size after MVR, with preservation of the MA mobility at the 2-year follow-up.

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“…(25) We can postulate that atrial fibrosis reflects abnormal wall stresses from the prolapsing leaflets, expanding annulus and dilated atrium (Figure1, 2–4)(26–28) and impinging MR jets, possibly augmented by abnormal interstitial mechanosensing due to DMR-causing mutations. (29)…”

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confidence: 99%