Mixed apnea metrics during diagnostic polysomnographies in obstructive sleep apnea patients with/without treatment-emergent central sleep apnea

Herkenrath, Simon; Pavsic, Katja; Treml, Marcel; Hagmeyer, Lars; Randerath, Winfried

doi:10.1183/13993003.congress-2019.pa824

Cited by 2 publications

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“…Lei F et al [ 57 ] reported that higher baseline mixed sleep apnea, especially in non-rapid eye movement sleep, was related to a higher incidence of TECSA in OSA patients. Herkenrath S et al [ 58 ] compared mixed apnea metrics during diagnostic PSG in OSA patients with or without TECSA, and found that those with TECSA had longer apneic duration, more frequent arousals, and shorter ventilatory duration, consistent with higher ventilatory control instability. However, there is still no consensus on the risk factors for TECSA, and the same risk factors are not always identified in the different studies.…”

Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

Treatment-emergent central sleep apnea: a unique sleep-disordered breathing

Zhang

Wang

Guo

et al. 2020

Chinese Medical Journal

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Treatment-emergent central sleep apnea (TECSA) is a specific form of sleep-disordered breathing, characterized by the emergence or persistence of central apneas during treatment for obstructive sleep apnea. The purpose of this review was to summarize the definition, epidemiology, potential mechanisms, clinical characteristics, and treatment of TECSA. We searched for relevant articles up to January 31, 2020, in the PubMed database. The prevalence of TECSA varied widely in different studies. The potential mechanisms leading to TECSA included ventilatory control instability, low arousal threshold, activation of lung stretch receptors, and prolonged circulation time. TECSA may be a self-limited disorder in some patients and could be resolved spontaneously over time with ongoing treatment of continuous positive airway pressure (CPAP). However, central apneas persist even with the regular CPAP therapy in some patients, and new treatment approaches such as adaptive servo-ventilation may be necessary. We concluded that several questions regarding TECSA remain, despite the findings of many studies, and it is necessary to carry out large surveys with basic scientific design and clinical trials for TECSA to clarify these irregularities. Further, it will be vital to evaluate the baseline demographic and polysomnographic data of TECSA patients more carefully and comprehensively.

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Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

Treatment-emergent central sleep apnea: a unique sleep-disordered breathing

Zhang

Wang

Guo

et al. 2020

Chinese Medical Journal

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Central and mixed apneas in children with obstructive sleep apnea: effect of adenotonsillectomy

Antunes,

Carvalho,

Marinho

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose Investigate the effect of adenotonsillectomy on mixed apnea index (MAI) and central apnea index (CAI) in children with moderate-to-severe obstructive sleep apnea syndrome (OSAS). Methods Observational retrospective analysis of polysomnographic data in children diagnosed with moderate-to-severe OSAS and without comorbidity, submitted to adenotonsillectomy. Results Data were available for 80 children, 55 boys and 25 girls, with a median age of 3.6 years (2.1–5.9). Before surgery AHI was 14.1 (11.0–18.4) per hour, with a median preoperative OAI of 7.1 (4.1–10.6), MAI of 1.2 (0.6–1.6) and CAI of 1.0 (0.4–2.0). Adenotonsillectomy caused significant improvements in MAI, from 1.2 (0.6–1.6) to 0.5 (0.1–0.8) (p < 0.001) and CAI from 1.0 (0.4–2.0) to 0.5 (0.1–0.9) (p < 0.001). This represents a normalization of MAI in 91.7% and CAI in 75.6% of children that had an abnormal value prior surgery. Conclusion Non obstructive apneas are common in children with OSAS. Adenotonsillectomy caused significant decrease not only in OAI, but also in MAI and CAI in children with moderate-to-severe OSAS.

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Mixed apnea metrics during diagnostic polysomnographies in obstructive sleep apnea patients with/without treatment-emergent central sleep apnea

Cited by 2 publications

References 0 publications

Treatment-emergent central sleep apnea: a unique sleep-disordered breathing

Treatment-emergent central sleep apnea: a unique sleep-disordered breathing

Central and mixed apneas in children with obstructive sleep apnea: effect of adenotonsillectomy

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