In the current workflow and heat exchange of a Casson nanoliquid across a penetrable media above a moving plate with variable thermal conductivity, adaptive thickness and chemical reaction are analyzed. First, the governing nonlinear equations of partial derivative terms with proper extreme conditions are changed into equations of ordinary derivative terms with suitable similarity conversions. Then the resulting equations are worked out using the Keller box method. The effects of various appropriate parameters are analyzed by constructing the visual representations of velocity, thermal, and fluid concentration. The velocity profile increased for shape parameter, and the opposite trend is observed for magnetic, Casson, porosity parameters. Temperature profile increases for magnetic, Casson, Brownian motion parameter, and thermophoresis parameters. Concentration profiles show a decreasing trend for wall thickness, Brownian movement, chemical reaction parameters. Also, skin friction values and calculated and matched with previous literature found in accordance. Also, local parameters Nusselt and Sherwood numbers are calculated and analyzed in detail.