Mixed Hydrotropy Solubilization Approach for Quantitative Estimation of Eprosartan Mesylate and Hydrochlorthiazide by UV Spectrophotometer

Jain, Ritika; Sahu, Vinod; Jain, Nilesh; Jain, S. K.

doi:10.4172/2153-2435.1000135

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…The amount of method development and assay validation required to support analysis of solutions from in vitro systems is a consideration of analytical laboratories performing this type of analysis. As there is little information from regulatory bodies as to how much assay development and validation is required, analytical laboratories need to decide on the best approach for this type of work [44]. In this paper, we describe an efficient 'fit-for-purpose' approach that has been developed to support buffer sample analysis from Safety Pharmacology hERG studies.…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Jena¹

2012

Pharm Anal Acta

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The analytical technique of High Performance Liquid Chromatography (HPLC) is used extensively thought the pharmaceutical industry. It allows simultaneously both qualitative and quantitative information of a drug. It is used to provide information on the composition of drug related samples. The information obtained may be qualitative, indicating what compounds are present in the sample. The information obtained may be qualitative, providing the actual amount of compounds in the sample. HPLC is used in all the different stages in the creation of new drug discoveries and also used routinely in the drug manufacturing process. The HPLC techniques is highly accessible to the author's knowledge this review represents the most exhaust description of instrumentation, method development, recent advancement, area of application. This article reviews the most recent advances in sample preparation, separation and the mass spectrometric aspects of high-throughput for method development.

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Section: Pharmaceutical Analysismentioning

confidence: 99%

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Jena¹

2012

Pharm Anal Acta

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“…Hydrotropes are a diverse class of chemical compounds first described by Neuberg (1916) that cause several-fold increases in water solubility of sparingly soluble drugs used to designate the increase in solubility of poorly water-soluble drugs in concentrated solutions of hydrotropic agents [10][11][12][13]. The increase in water solubility is probably due to the formation of organized assemblies of hydrotrope molecules at critical concentrations [14][15]. Many drugs that are poorly soluble in water have been made soluble through the use of different hydrotropic solutions.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of glimepiride hydrotropic solid dispersion to enhance the solubility and dissolution

Lakumalla,

Podichety,

Maddali

2024

JAPR

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Background: Glimepiride lowers blood sugar levels in the body, and treats type 2 diabetes mellitus. But the main problem with the drug is its low aqueous solubility. The primary purpose of this study is to increase its solubility in an aqueous medium by using amphiphilic hydrotropic agents instead of harmful, volatile organic solvents. Methodology: A solubility study of Glimepiride was carried out using various hydrotropic agents at 10%, 20%, 30%, and 40%. In mixed hydrography, 30% of the hydrotropic agents were chosen for making blends due to their highest solubility. The blend's solubility was raised more than 50 times at fixed concentrations of urea (20%) and sodium acetate (10%) in a mixed hydrotropic solution. The solubility of Glimepiride in distilled water is 0.0038 mg/ml; in 30% urea, 49.512 ug/ml; and in 30% sodium acetate, 40.43 ug/ml. The optimized blend prepared hydrotropic solid dispersions by physical mixing and solvent evaporation. It was evaluated for drug content, FTIR, SEM, X-ray diffraction, and in vitro drug release studies. Finally, the drug release profile of the prepared tablet is compared with an already available consumer product. Result: HSD-5 showed an in-vitro drug release of 84.77±0.44 at 90 min, which is higher than the remaining formulations, and no significant change was found in drug content or drug release after 15, 30, and 45 days of stability studies. Scanning electron microscopy (SEM) showed homogenous solid dispersion, crystallinity was determined using X-ray diffraction, and FTIR showed good drug compatibility with carriers. The drug release profile of the prepared tablet was higher than that of the available consumer product. Conclusion: This study revealed that hydrotropic agents can potentially increase glimepiride's solubility and drug release. This approach can effectively enhance the solubility of poorly water-soluble drugs.

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“…Maheshwari and Jain et al has used sodium salicylate, sodium benzoate, urea, nicotinamide, sodium citrate and sodium acetate are the most common examples of hydrotropic agents utilized to increase the water solubility of drug [23][24][25][26][27][28][29][30][31][32][33][34] . Various organic solvents such as methanol, chloroform, dimethyl formamide and acetonitrile have been employed for solubilization of poorly water-soluble drugs to carry out spectrophotometric analysis.…”

mentioning

confidence: 99%

Untitled

2013

IJPSR

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Two simple, accurate, novel, safe and precise methods developed for the simultaneous estimation of poorly water-soluble drugs Levofloxacin and Ornidazole in tablet dosage form using 2M sodium acetate and 8M urea solution (50:50% W/W) as mixed hydrotropic solution. Sodium acetate and urea solution did not show any absorbance above 240 nm and thus no interference in the estimation of drugs were seen. LEVO and OZ follows the Beer's law in the concentration range of 5-25 µg/ml (r 2 = 0.9997 and 0.9998). Method-A simultaneous equation method employs 287 and 320 nm as two analytical wavelengths, method-B is absorption ratio method, which uses 301 and 320 nm as two analytical wavelengths were used for estimation of LEVO and OZ. The mean percent label claims of tablet dosage were found to be 98.528±0.431 and 97.916±0.732 in method A, 97.586±0.821 and 98.642±0.293 in method B for LEVO and OZ respectively. The standard deviation, coefficient of variance and standard error were obtained for LEVO and OZ was satisfactorily low. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values therefore the both methods can be used for routine monitoring of LEVO and OZ in industry in the assay of bulk drug and tablets.

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Mixed Hydrotropy Solubilization Approach for Quantitative Estimation of Eprosartan Mesylate and Hydrochlorthiazide by UV Spectrophotometer

Cited by 6 publications

References 8 publications

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Design and characterization of glimepiride hydrotropic solid dispersion to enhance the solubility and dissolution

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