Mixed <i>Candida albicans</i> and <i>Candida glabrata</i> populations associated with the pathogenesis of denture stomatitis

Coco, B.; Bagg, J.; Cross, Laura J.; Jose, Anto; Cross, J. N.; Ramage, Gordon

doi:10.1111/j.1399-302x.2008.00439.x

Cited by 254 publications

(251 citation statements)

References 41 publications

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“…In such studies, C. albicans is reported as being the most prevalent Candida species on the dentures of stomatitis patients, with an incidence of 54-75%, and a lower incidence evident on the dentures on non DS patients (39%) [28][29][30]. In the present study, similar findings were reported, with a 57% incidence of oral colonisation by C. albicans in DS patients and a 22% incidence in non-DS patients.…”

Section: Discussionsupporting

confidence: 80%

“…A number of previous investigations have examined the microbiology of DS, particularly with respect to the Candida species colonisation of the oral cavity [28][29][30]. In such studies, C. albicans is reported as being the most prevalent Candida species on the dentures of stomatitis patients, with an incidence of 54-75%, and a lower incidence evident on the dentures on non DS patients (39%) [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

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Immune Response and Candidal Colonisation in Denture Associated Stomatitis

Rogers¹,

X-Q²,

Lewis³

et al. 2013

J Clin Cell Immunol

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Denture stomatitis (DS) is an inflammatory oral condition affecting most frequently the palatal mucosa covered by the fitting surface of a denture. The aim of this study was to determine the local cytokine profile generated in DS, as well as the level and identity of Candida involved. Palatal inflammation was determined by clinical indices in 93 upper denture-wearing subjects (42 with DS). The level of selected cytokines in palatal fluid was measured by cytometric bead array. Grouping of the cytokines associated with Th1, Th2, Th17 and regulatory T cell (Treg) responses, showed significant increases particularly for Th1 and Th17 responses. Using imprint culture, Candida was isolated from 48 patients (29 with DS). DS patients had significantly higher numbers of Candida isolated from the fitting surface of the denture (P=0.0113). However, there was significantly (P=0.03) higher numbers of Candida on the palate of non-DS patients. In summary, it would appear that an appropriate immune response is elicited in DS patients and whilst this appears to reduce Candida levels on inflamed mucosa, it is probable that Candida on the fitting surface of the denture remain protected from local immune responses which results in a continued reservoir of infection.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Immune Response and Candidal Colonisation in Denture Associated Stomatitis

Rogers¹,

X-Q²,

Lewis³

et al. 2013

J Clin Cell Immunol

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“…Although Lactobacillus species are the most commonly isolated bacteria from DS biofilms, other Candida species, namely C. glabrata, have also been detected [92]. Coinfection with C. glabrata results in upregulation of key virulence genes (ALS3 and HWP1) in C. albicans [93].…”

Section: Denture Stomatitis: Mixing In a Rough Neighbourhoodmentioning

confidence: 99%

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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Purpose of Review Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

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“…Patients were excluded from this study if they had been receiving antimicrobial treatment or using prescription mouthwashes within six months prior to sampling. Dentures were removed from the patient's mouth and placed in sterile bags (Fisher Scientific) filled with 50 ml phosphate buffered saline ([PBS, Sigma-Aldrich), and placed in a sonic bath (Ultrawave) for 5 min to remove the biofilm from the surface (24). The denture sonicate was centrifuged for 10 min at 3700 x g [6000 r.p.m.…”

Section: Patient Samplingmentioning

confidence: 99%

Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity

O’Donnell

Alalwan

Kean

et al. 2017

Journal of Medical Microbiology

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Mixed Candida albicans and Candida glabrata populations associated with the pathogenesis of denture stomatitis

Abstract: This study has demonstrated that mixed C. albicans and C. glabrata biofilms may play an important role in the pathogenesis associated with severe inflammation in denture wearers.

Cited by 254 publications

References 41 publications

Immune Response and Candidal Colonisation in Denture Associated Stomatitis

Immune Response and Candidal Colonisation in Denture Associated Stomatitis

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity

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