Mixed ligand ruthenium(III) complexes of benzaldehyde 4-methyl-3-thiosemicarbazones with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA binding, DNA cleavage, antioxidative and cytotoxic activity

Sampath, Krishnan; Sathiyaraj, Subbaiyan; Raja, G.; Jayabalakrishnan, Chinnasamy

doi:10.1016/j.molstruc.2013.04.051

Cited by 32 publications

(14 citation statements)

References 36 publications

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“…Greater stability of the ligands compared with their complexes suggests a powerful intramolecular H-bonding in the ligands [81,82]. Complexes 1,6,8,14,15, and 16 were taken as representative examples for thermal analysis. The results of thermal analysis of the complexes ( Table 2) are in good agreement with the theoretical formulae as suggested from elemental analyses.…”

Section: Thermal Analysismentioning

confidence: 99%

“…Mixed-ligand complexes have been extensively studied following recognition that they play an important role in biological processes and serve as suitable models for valuable information in the elucidation of enzymatic processes of biological relevance [7,8]. Also, these complexes showed significant antibacterial, antifungal, and anticancer activity [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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Section: Thermal Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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“…kinetic ligand-exchange, variable oxidation states of ruthenium may be used to fine-tune the properties of the complexes. 2 In addition, low toxicity of ruthenium complexes towards the normal cells is advantages of using these in medicinal applications. Also, the entrance of two ruthenium(III) based drugs into the clinical trials is increased interest on this metal.…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF RUTHENIUM(III) (E)-2-((6-METHYLBENZO[d]THIAZOL-2-YLIMINO)METHYL)PHENOLCOMPLEXES

2017

RJC

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Ruthenium(III) complexes of the type [RuX2(PPh3)(L)] (where X = Cl/Br; L = Benzothiazolyl-Salal Schiff base ligand) has been synthesized. The synthesized complexes were characterized by various physicochemical and spectral techniques. An octahedral geometry has been tentatively proposed for all the complexes. The cytotoxic activity of the synthesized ruthenium(III) complexes has shown significant activity against a panel of microbes.

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“…Metal-thiosemicarbazone complexes have been found to have interesting catalytic [3][4][5][6] as well as biological applications 5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . However, it has been also reported that by suitable structural variations thiosemicarbazone ligands could also become potential anticarcinogenic agents [25][26][27][28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

Asynthesis, Crystal Structures and in Vitro Anticancer Studies of New Thiosemicarbazone Derivatives

Hussein

Iqbal

Asif

et al. 2015

Phosphorus, Sulfur, and Silicon and the Related Elements

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Thiosemicarbazones are an important class of compounds having significant biological properties. These compounds are used as stable ligands for the synthesis of coordination compounds of biological worth. The current study describes syntheses of four new N(3)-ethyl thiosemicarbazone derivatives and their in vitro anticancer testing. The purpose of the study was to observe the effect of various subtitutions at the aromatic ring against the growth of cancerous cell. The synthesized compounds were characterized by NMR ( 1 H & 13 C) spectroscopy and the molecular structures of each of the compounds were determined using single crystal X-ray crystallographic technique. Interestingly, compound 4 appeared to have two crystallographically different units (A and B), having slightly different bond lengths and angles compared to each other. All the compounds were tested for their in vitro anticancer properties against Human Colon Cancer (HCT 116) and Breast Cancer (MCF-7) cell lines. The compounds (1-2), having halide (Cl and Br) substitutions, showed significant activity compared to those having ethoxy and allyl substitutions (3-4), indicating the possible involvement of halides against cancerous cells.

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Mixed ligand ruthenium(III) complexes of benzaldehyde 4-methyl-3-thiosemicarbazones with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA binding, DNA cleavage, antioxidative and cytotoxic activity

Cited by 32 publications

References 36 publications

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF RUTHENIUM(III) (E)-2-((6-METHYLBENZO[d]THIAZOL-2-YLIMINO)METHYL)PHENOLCOMPLEXES

Asynthesis, Crystal Structures and in Vitro Anticancer Studies of New Thiosemicarbazone Derivatives

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