Ceramic angular contact ball bearing is widely used in a high-speed motorised spindle because of their excellent properties such as wear resistance, high temperature resistance, and corrosion resistance. In this study, the characteristics and influencing factors of the radiation noise for a full ceramic angular contact ball bearing applied in the motorised spindle are investigated. Based on a single factor test method, the variations of bearing noise with preload, oil supply, and rotation speed were investigated, and then, the optimal preload and oil supply under the specific speed were obtained. The sound field directivity in the circumferential distribution of the bearing noise was discussed, and the reasons for the uneven distribution of the sound field were elucidated. According to the experimental results, a prediction model on the radiation noise of a full ceramic angular contact ball bearing under certain conditions was proposed. The conclusions will provide a reference for reducing the radiation noise of full ceramic angular contact ball bearings in high-speed operation and improving the bearing performance.