Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma

Tijink, M.S.L.; Wester, Maarten; Glorieux, Griet; Gerritsen, Karin G.F.; Sun, Jiatong; Swart, Pieter C.; Borneman, Zandrie; Weßling, Matthias; Vanholder, Raymond; Joles, Jaap A.; Stamatialis, Dimitrios

doi:10.1016/j.biomaterials.2013.07.008

Cited by 133 publications

(112 citation statements)

References 46 publications

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“…125 However, using a dual-layer hollow fiber membrane with embedded adsorptive carbon particles has been recently demonstrated to effectively clear the daily production of IS and pCS. 126 IS and pCS are particularly difficult to clear from the circulation, largely because of their high protein-binding affinity and large distribution volume. Therefore, strategies to decrease the protein-binding capacity of the plasma may enhance PBUTs…”

Section: Strategy 2: Enhancing Toxin Removal By Rrtmentioning

confidence: 99%

Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities

Lekawanvijit

2015

Circ J

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Section: Strategy 2: Enhancing Toxin Removal By Rrtmentioning

confidence: 99%

Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities

Lekawanvijit

2015

Circ J

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“…However, Lesaffer et al (2000) found that during hemodialysis uremic toxins removal is only 29% for p-cresol versus 75% for urea and 66% for creatinine. Fortunately, recent studies had shown that uremic toxins may also be adsorbed onto dialysis membranes (Tijinka et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Adsorption of uremic toxins over dealuminated zeolites

Koubaissy

Toufaily

Yaseen

et al. 2016

Adsorption Science & Technology

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In this study, adsorption capacities of uremic toxins over Faujasite (HFAU) and Beta (HBEA) have been evaluated by varying the composition of solvent by using water, physiological, and sodium chloride solutions. HFAU was found to be more efficient in adsorption of these molecules. The adsorption results over HFAU were compared in various conditions to understand the adsorption mechanism. Thus, the adsorption mechanism was confirmed also by Fourier transform infrared and X-ray diffraction analysis, and it is found to be through the interaction of creatinine by hydrogen bonding on two types of sites on zeolites. Pseudo-second-order equation described well the adsorption kinetics data. Equilibrium isotherms were determined by Fowler-Guggenheim model. Finally, hydrophobic HFAU zeolite seems to be an efficient adsorbent; it is able to be easily regenerated under air, through retention of these initial adsorption properties.

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“…In fact, Ronco [4] asked the membrane manufacturers to consider the possibility of mixing the biomaterial of a specific membrane with a sorbent material based on a significant enhancement of internal filtration and backfiltration in hollow-fiber hemodialyzers. Recently, some of the authors of this editorial proposed a combination of diffusion and adsorption in one membrane, the so-called mixed matrix membrane (MMM), for removal of uremic solutes [7,8,9]. The MMM concept had been proposed earlier as an alternative to traditional chromatographic columns [10].…”

Section: Figmentioning

confidence: 99%